Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up
Introduction and hypothesis Interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often occur concomitantly without an obvious reason. It is important to determine the relationship between these related diseases. We aimed to determine whether IBS increase the risk o...
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| Veröffentlicht in: | International Urogynecology Journal 2021-05, Vol.32 (5), p.1307-1312 |
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| creator | Chang, Kun-Min Lee, Ming-Huei Lin, Hsuan-Hung Wu, Shang-Liang Wu, Huei-Ching |
| description | Introduction and hypothesis
Interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often occur concomitantly without an obvious reason. It is important to determine the relationship between these related diseases. We aimed to determine whether IBS increase the risk of IC/BPS.
Methods
We identified newly diagnosed IBS patients between 2002 and 2013 from a nationwide database as the IBS cohort. Subjects diagnosed with IC/BPS before IBS were excluded. Cox’s regression analysis with a hazard ratio (HR) of IC/BPS between IBS and the non-IBS cohort was applied to unmatched and matched (16 confounders of propensity scores) models. The time from diagnosis of IBS to IC/BPS was also calculated.
Results
In the unmatched group, which included 100,124 IBS (55% female) and 874,048 non-IBS patients, the IC/BPS adjusted HR was 1.292 (95% confidence interval [CI], 1.131–1.476;
p
< 0.0001) in the IBS cohort compared with the non-IBS cohort. In the matched group, there were 85,359 patients in each cohort, and the IC/BPS HR was 1.599 (95% CI, 1.344–1.903;
p
< 0.0001). The average numbers of years until the development of IC/BPS in the IBS cohort and non-IBS cohort were 4.60 ± 2.58 (
n
= 253) and 5.99 ± 3.49 (
n
= 295) years, respectively.
Conclusions
IBS was shown to increase the risk of IC/BPS in this 12-year cohort study. The time from the diagnosis of IBS to IC/BPS was 5.35 ± 3.18 years. A common pathophysiology of IBS and IC/BPS is possible. Clinicians should be mindful of the association and promote collaborative care of these two elusive diseases. |
| doi_str_mv | 10.1007/s00192-021-04711-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2492661643</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2492661643</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-fb3b1521fc7efa0e43aeeaa4bec61c587e78ad8441f89fdc35a16ad501f1fa073</originalsourceid><addsrcrecordid>eNp9kctuFDEQRS0EIsPAD7BAltiwcVJ-9WOFovCUIrGBteV2lxMHd3uwuxXNB_Df8WRCkFiwcsl16tiqS8hrDqccoD0rALwXDARnoFrOmXxCNlxJySQI-ZRsoJctk6oRJ-RFKTcAoEDDc3IiZSNAy35Dfn9IWGjIOSx2iEiHdIuRlv085jQhDbPLaAvS5RppDuUnTb5eLpjLEpZgI3X7-6qcDdGOI2a6s2F-FLyn59Sl65QXWpZ13B_GY5qvaDVM1KcY0y1bdy_JM29jwVcP55b8-PTx-8UXdvnt89eL80vmZKsX5gc5cC24dy16C6ikRbRWDega7nTXYtvZsVOK-673o5Pa8saOGrjnlW_llrw7enc5_VqxLGYKxWGMdsa0FiNUL5qGN3WHW_L2H_QmrXmuvzNC1_02otNQKXGkXE6lZPRml8Nk895wMIeQzDEkU0My9yGZg_rNg3odJhwfR_6kUgF5BEptzVeY_779H-0dGd6fXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2530262850</pqid></control><display><type>article</type><title>Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up</title><source>SpringerLink Journals (MCLS)</source><creator>Chang, Kun-Min ; Lee, Ming-Huei ; Lin, Hsuan-Hung ; Wu, Shang-Liang ; Wu, Huei-Ching</creator><creatorcontrib>Chang, Kun-Min ; Lee, Ming-Huei ; Lin, Hsuan-Hung ; Wu, Shang-Liang ; Wu, Huei-Ching</creatorcontrib><description>Introduction and hypothesis
Interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often occur concomitantly without an obvious reason. It is important to determine the relationship between these related diseases. We aimed to determine whether IBS increase the risk of IC/BPS.
Methods
We identified newly diagnosed IBS patients between 2002 and 2013 from a nationwide database as the IBS cohort. Subjects diagnosed with IC/BPS before IBS were excluded. Cox’s regression analysis with a hazard ratio (HR) of IC/BPS between IBS and the non-IBS cohort was applied to unmatched and matched (16 confounders of propensity scores) models. The time from diagnosis of IBS to IC/BPS was also calculated.
Results
In the unmatched group, which included 100,124 IBS (55% female) and 874,048 non-IBS patients, the IC/BPS adjusted HR was 1.292 (95% confidence interval [CI], 1.131–1.476;
p
< 0.0001) in the IBS cohort compared with the non-IBS cohort. In the matched group, there were 85,359 patients in each cohort, and the IC/BPS HR was 1.599 (95% CI, 1.344–1.903;
p
< 0.0001). The average numbers of years until the development of IC/BPS in the IBS cohort and non-IBS cohort were 4.60 ± 2.58 (
n
= 253) and 5.99 ± 3.49 (
n
= 295) years, respectively.
Conclusions
IBS was shown to increase the risk of IC/BPS in this 12-year cohort study. The time from the diagnosis of IBS to IC/BPS was 5.35 ± 3.18 years. A common pathophysiology of IBS and IC/BPS is possible. Clinicians should be mindful of the association and promote collaborative care of these two elusive diseases.</description><identifier>ISSN: 0937-3462</identifier><identifier>EISSN: 1433-3023</identifier><identifier>DOI: 10.1007/s00192-021-04711-3</identifier><identifier>PMID: 33620539</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Bladder ; Chronic fatigue syndrome ; Cohort analysis ; Comorbidity ; Gynecology ; Health insurance ; Hospitals ; Hypotheses ; Irritable bowel syndrome ; Medicine ; Medicine & Public Health ; Original Article ; Pain ; Pathophysiology ; Population-based studies ; Urinary tract diseases ; Urinary tract infections ; Urogenital system ; Urology</subject><ispartof>International Urogynecology Journal, 2021-05, Vol.32 (5), p.1307-1312</ispartof><rights>The International Urogynecological Association 2021</rights><rights>The International Urogynecological Association 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-fb3b1521fc7efa0e43aeeaa4bec61c587e78ad8441f89fdc35a16ad501f1fa073</citedby><cites>FETCH-LOGICAL-c375t-fb3b1521fc7efa0e43aeeaa4bec61c587e78ad8441f89fdc35a16ad501f1fa073</cites><orcidid>0000-0002-1067-5904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00192-021-04711-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00192-021-04711-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33620539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Kun-Min</creatorcontrib><creatorcontrib>Lee, Ming-Huei</creatorcontrib><creatorcontrib>Lin, Hsuan-Hung</creatorcontrib><creatorcontrib>Wu, Shang-Liang</creatorcontrib><creatorcontrib>Wu, Huei-Ching</creatorcontrib><title>Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up</title><title>International Urogynecology Journal</title><addtitle>Int Urogynecol J</addtitle><addtitle>Int Urogynecol J</addtitle><description>Introduction and hypothesis
Interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often occur concomitantly without an obvious reason. It is important to determine the relationship between these related diseases. We aimed to determine whether IBS increase the risk of IC/BPS.
Methods
We identified newly diagnosed IBS patients between 2002 and 2013 from a nationwide database as the IBS cohort. Subjects diagnosed with IC/BPS before IBS were excluded. Cox’s regression analysis with a hazard ratio (HR) of IC/BPS between IBS and the non-IBS cohort was applied to unmatched and matched (16 confounders of propensity scores) models. The time from diagnosis of IBS to IC/BPS was also calculated.
Results
In the unmatched group, which included 100,124 IBS (55% female) and 874,048 non-IBS patients, the IC/BPS adjusted HR was 1.292 (95% confidence interval [CI], 1.131–1.476;
p
< 0.0001) in the IBS cohort compared with the non-IBS cohort. In the matched group, there were 85,359 patients in each cohort, and the IC/BPS HR was 1.599 (95% CI, 1.344–1.903;
p
< 0.0001). The average numbers of years until the development of IC/BPS in the IBS cohort and non-IBS cohort were 4.60 ± 2.58 (
n
= 253) and 5.99 ± 3.49 (
n
= 295) years, respectively.
Conclusions
IBS was shown to increase the risk of IC/BPS in this 12-year cohort study. The time from the diagnosis of IBS to IC/BPS was 5.35 ± 3.18 years. A common pathophysiology of IBS and IC/BPS is possible. Clinicians should be mindful of the association and promote collaborative care of these two elusive diseases.</description><subject>Age</subject><subject>Bladder</subject><subject>Chronic fatigue syndrome</subject><subject>Cohort analysis</subject><subject>Comorbidity</subject><subject>Gynecology</subject><subject>Health insurance</subject><subject>Hospitals</subject><subject>Hypotheses</subject><subject>Irritable bowel syndrome</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pain</subject><subject>Pathophysiology</subject><subject>Population-based studies</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urogenital system</subject><subject>Urology</subject><issn>0937-3462</issn><issn>1433-3023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctuFDEQRS0EIsPAD7BAltiwcVJ-9WOFovCUIrGBteV2lxMHd3uwuxXNB_Df8WRCkFiwcsl16tiqS8hrDqccoD0rALwXDARnoFrOmXxCNlxJySQI-ZRsoJctk6oRJ-RFKTcAoEDDc3IiZSNAy35Dfn9IWGjIOSx2iEiHdIuRlv085jQhDbPLaAvS5RppDuUnTb5eLpjLEpZgI3X7-6qcDdGOI2a6s2F-FLyn59Sl65QXWpZ13B_GY5qvaDVM1KcY0y1bdy_JM29jwVcP55b8-PTx-8UXdvnt89eL80vmZKsX5gc5cC24dy16C6ikRbRWDega7nTXYtvZsVOK-673o5Pa8saOGrjnlW_llrw7enc5_VqxLGYKxWGMdsa0FiNUL5qGN3WHW_L2H_QmrXmuvzNC1_02otNQKXGkXE6lZPRml8Nk895wMIeQzDEkU0My9yGZg_rNg3odJhwfR_6kUgF5BEptzVeY_779H-0dGd6fXw</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Chang, Kun-Min</creator><creator>Lee, Ming-Huei</creator><creator>Lin, Hsuan-Hung</creator><creator>Wu, Shang-Liang</creator><creator>Wu, Huei-Ching</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1067-5904</orcidid></search><sort><creationdate>20210501</creationdate><title>Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up</title><author>Chang, Kun-Min ; Lee, Ming-Huei ; Lin, Hsuan-Hung ; Wu, Shang-Liang ; Wu, Huei-Ching</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-fb3b1521fc7efa0e43aeeaa4bec61c587e78ad8441f89fdc35a16ad501f1fa073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Bladder</topic><topic>Chronic fatigue syndrome</topic><topic>Cohort analysis</topic><topic>Comorbidity</topic><topic>Gynecology</topic><topic>Health insurance</topic><topic>Hospitals</topic><topic>Hypotheses</topic><topic>Irritable bowel syndrome</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pain</topic><topic>Pathophysiology</topic><topic>Population-based studies</topic><topic>Urinary tract diseases</topic><topic>Urinary tract infections</topic><topic>Urogenital system</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Kun-Min</creatorcontrib><creatorcontrib>Lee, Ming-Huei</creatorcontrib><creatorcontrib>Lin, Hsuan-Hung</creatorcontrib><creatorcontrib>Wu, Shang-Liang</creatorcontrib><creatorcontrib>Wu, Huei-Ching</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International Urogynecology Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Kun-Min</au><au>Lee, Ming-Huei</au><au>Lin, Hsuan-Hung</au><au>Wu, Shang-Liang</au><au>Wu, Huei-Ching</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up</atitle><jtitle>International Urogynecology Journal</jtitle><stitle>Int Urogynecol J</stitle><addtitle>Int Urogynecol J</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>32</volume><issue>5</issue><spage>1307</spage><epage>1312</epage><pages>1307-1312</pages><issn>0937-3462</issn><eissn>1433-3023</eissn><abstract>Introduction and hypothesis
Interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often occur concomitantly without an obvious reason. It is important to determine the relationship between these related diseases. We aimed to determine whether IBS increase the risk of IC/BPS.
Methods
We identified newly diagnosed IBS patients between 2002 and 2013 from a nationwide database as the IBS cohort. Subjects diagnosed with IC/BPS before IBS were excluded. Cox’s regression analysis with a hazard ratio (HR) of IC/BPS between IBS and the non-IBS cohort was applied to unmatched and matched (16 confounders of propensity scores) models. The time from diagnosis of IBS to IC/BPS was also calculated.
Results
In the unmatched group, which included 100,124 IBS (55% female) and 874,048 non-IBS patients, the IC/BPS adjusted HR was 1.292 (95% confidence interval [CI], 1.131–1.476;
p
< 0.0001) in the IBS cohort compared with the non-IBS cohort. In the matched group, there were 85,359 patients in each cohort, and the IC/BPS HR was 1.599 (95% CI, 1.344–1.903;
p
< 0.0001). The average numbers of years until the development of IC/BPS in the IBS cohort and non-IBS cohort were 4.60 ± 2.58 (
n
= 253) and 5.99 ± 3.49 (
n
= 295) years, respectively.
Conclusions
IBS was shown to increase the risk of IC/BPS in this 12-year cohort study. The time from the diagnosis of IBS to IC/BPS was 5.35 ± 3.18 years. A common pathophysiology of IBS and IC/BPS is possible. Clinicians should be mindful of the association and promote collaborative care of these two elusive diseases.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33620539</pmid><doi>10.1007/s00192-021-04711-3</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1067-5904</orcidid></addata></record> |
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| source | SpringerLink Journals (MCLS) |
| subjects | Age Bladder Chronic fatigue syndrome Cohort analysis Comorbidity Gynecology Health insurance Hospitals Hypotheses Irritable bowel syndrome Medicine Medicine & Public Health Original Article Pain Pathophysiology Population-based studies Urinary tract diseases Urinary tract infections Urogenital system Urology |
| title | Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up |
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