Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling

The NAD+-dependent deacetylase, Sirtuin 1 (SIRT1) is involved in prostate cancer pathogenesis. However, the actual contribution is unclear as some reports propose a protective role while others suggest it is harmful. We provide evidence for a contextual role for SIRT1 in prostate cancer. Our data sh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2021-05, Vol.505, p.24-36
Hauptverfasser:	Huang, Shih-Bo, Thapa, D., Munoz, A.R., Hussain, S.S., Yang, X., Bedolla, R.G., Osmulski, P., Gaczynska, M.E., Lai, Z., Chiu, Yu-Chiao, Wang, Li-Ju, Chen, Y., Rivas, P., Shudde, C., Reddick, R.L., Miyamoto, H., Ghosh, R., Kumar, A.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Binding sites Biochemical recurrence Cell growth Cell survival Datasets E2F protein Gene expression Genomes Medical prognosis Myc protein NAD Prostate cancer SIRT1 SIRT1 protein Software Tumor cell lines Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!