Neuropeptide Y and glutamatergic mechanisms in the amygdala and ventral hippocampus differentially mediate impaired social behavior in diabetic mice

•In diabetic mice AMPA and NPY Y2 receptor function in social behavior was studied.•NBQX injected into hippocampus or amygdala ameliorated diabetic social impairment.•NPY levels were increased in amygdala, but not in hippocampus, of diabetic mice.•BIIE 0246 injected into amygdala ameliorated diabeti...

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Veröffentlicht in:	Behavioural brain research 2021-05, Vol.405, p.113195-113195, Article 113195
Hauptverfasser:	Ueda, Daiki, Yonemochi, Naomi, Kamata, Tomohiro, Kamei, Junzo, Waddington, John L., Ikeda, Hiroko
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptors Animals Arginine - analogs & derivatives Arginine - pharmacology Basolateral amygdala Basolateral Nuclear Complex - drug effects Basolateral Nuclear Complex - metabolism Behavior, Animal - drug effects Behavior, Animal - physiology Benzazepines - pharmacology Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - physiopathology Diabetes Complications - drug therapy Diabetes Complications - etiology Diabetes Complications - metabolism Diabetes Complications - physiopathology Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Excitatory Amino Acid Antagonists - pharmacology Hippocampus - drug effects Hippocampus - metabolism Male Mice Mice, Inbred ICR Neuropeptide Y - physiology NPY Y2 receptors Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - physiology Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - physiology Social Behavior Social novelty preference Ventral hippocampus
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