Impact of changes in the topographic classification of Klatskin tumor on incidence of intra‐ and extrahepatic bile duct cancer: A population‐based national cancer registry study
Background Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence of intrahepatic BDC (iBDC). This study aimed to investigate the impact of misclassified Klatskin tumor on iBDC and eBDC incidences in Korea, where BDC is hig...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2021-09, Vol.28 (9), p.740-750 |
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| creator | Kang, Mee Joo Lim, Jiwon Han, Sung‐Sik Park, Hyeong Min Kim, Sun‐Whe Won, Young‐Joo Park, Sang‐Jae |
| description | Background
Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence of intrahepatic BDC (iBDC). This study aimed to investigate the impact of misclassified Klatskin tumor on iBDC and eBDC incidences in Korea, where BDC is highly endemic.
Methods
The data of incidence, topography and morphology code of BDC from 1999 to 2017 were obtained from the Korea Central Cancer Registry, which covers the entire 51.6 million Korean population. For misclassification analysis, all Klatskin tumors were reclassified as eBDC.
Results
Klatskin tumors accounted for 13.5% of all 81 414 BDC cases. In the registry, an average of 59.7% of Klatskin tumors were classified as iBDC, gradually decreasing from 95.5% to 16.9%. Misclassification led to a 17.3% overestimation of iBDC cases and a 15.0% underestimation of eBDC cases on average. After reclassification, age standardized rate (ASR) of incidence per 100 000 population decreased in iBDC from 3.4 to 2.9 and increased in eBDC from 2.8 to 3.2. Average annual percentage change of iBDC and eBDC incidences were 2.0% and 1.2%, respectively, but ASR of iBDC significantly decreased since 2012 (P |
| doi_str_mv | 10.1002/jhbp.916 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2492290089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2576742412</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3736-91f0ada76dc1b1c2a010f3ae5ea52f40cc935fd979a59d326c7779aa0f13b6ef3</originalsourceid><addsrcrecordid>eNp1kUtu1TAUhi0EolWpxAqQJSZMUvxI7GtmpQJaqAQDGEcnftz4ktjBTgR3xhLYDBtiJTjtpUhIeGIf-zufZf8IPabkjBLCnu_6bjpTVNxDx3QjNpVQG3b_bi3rI3Sa846UwSlXnDxER5wL2shaHqOfV-MEesbRYd1D2NqMfcBzb_Ecp7hNMPVeYz1Azt55DbOPYYXfDTDnzyu6jDHhsumD9sYGbddjH-YEv77_wBAMtt9K0dupNGvc-cFis5QrNRQ4vcDneIrTMtyoS0sH2RocbkoYDhROduvznPY4z4vZP0IPHAzZnh7mE_Tp9auPF5fV9fs3Vxfn15XmkotKUUfAgBRG045qBoQSx8E2FhrmaqK14o0zSipolOFMaCnLGoijvBPW8RP07NY7pfhlsXluR5-1HQYINi65ZbViTBGyUQV9-g-6i0sqLyhUI4WsWU3ZX6FOMedkXTslP0Lat5S0a5rtmmZb0izok4Nw6UZr7sA_2RWgugW-li_d_1fUvr18-WEV_gYKya6k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2576742412</pqid></control><display><type>article</type><title>Impact of changes in the topographic classification of Klatskin tumor on incidence of intra‐ and extrahepatic bile duct cancer: A population‐based national cancer registry study</title><source>Wiley Online Library All Journals</source><creator>Kang, Mee Joo ; Lim, Jiwon ; Han, Sung‐Sik ; Park, Hyeong Min ; Kim, Sun‐Whe ; Won, Young‐Joo ; Park, Sang‐Jae</creator><creatorcontrib>Kang, Mee Joo ; Lim, Jiwon ; Han, Sung‐Sik ; Park, Hyeong Min ; Kim, Sun‐Whe ; Won, Young‐Joo ; Park, Sang‐Jae</creatorcontrib><description>Background
Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence of intrahepatic BDC (iBDC). This study aimed to investigate the impact of misclassified Klatskin tumor on iBDC and eBDC incidences in Korea, where BDC is highly endemic.
Methods
The data of incidence, topography and morphology code of BDC from 1999 to 2017 were obtained from the Korea Central Cancer Registry, which covers the entire 51.6 million Korean population. For misclassification analysis, all Klatskin tumors were reclassified as eBDC.
Results
Klatskin tumors accounted for 13.5% of all 81 414 BDC cases. In the registry, an average of 59.7% of Klatskin tumors were classified as iBDC, gradually decreasing from 95.5% to 16.9%. Misclassification led to a 17.3% overestimation of iBDC cases and a 15.0% underestimation of eBDC cases on average. After reclassification, age standardized rate (ASR) of incidence per 100 000 population decreased in iBDC from 3.4 to 2.9 and increased in eBDC from 2.8 to 3.2. Average annual percentage change of iBDC and eBDC incidences were 2.0% and 1.2%, respectively, but ASR of iBDC significantly decreased since 2012 (P < 0.0001).
Conclusions
Misclassification of Klatskin tumors has remarkable impact on the incidence of iBDC and eBDC in a highly endemic country.
Highlight
In cancer registries, Klatskin tumor has not been consistently classified as intra‐ or extrahepatic bile duct cancer over time. Kang and colleagues revealed that changes in topographic classification of Klatskin tumor have led to over‐ and underestimation of the incidence of intra‐ and extrahepatic bile duct cancer, respectively, in Korea.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.916</identifier><identifier>PMID: 33615747</identifier><language>eng</language><publisher>Japan: Wiley Subscription Services, Inc</publisher><subject>bile duct neoplasms ; Bile ducts ; Cancer ; Cholangiocarcinoma ; epidemiology ; incidence ; Klatskin tumor ; Population-based studies ; Tumors</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2021-09, Vol.28 (9), p.740-750</ispartof><rights>2021 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery.</rights><rights>Copyright © 2021 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3736-91f0ada76dc1b1c2a010f3ae5ea52f40cc935fd979a59d326c7779aa0f13b6ef3</citedby><cites>FETCH-LOGICAL-c3736-91f0ada76dc1b1c2a010f3ae5ea52f40cc935fd979a59d326c7779aa0f13b6ef3</cites><orcidid>0000-0001-9861-6740 ; 0000-0001-7047-7961 ; 0000-0002-3322-7792 ; 0000-0001-5582-9420 ; 0000-0001-6315-6019 ; 0000-0002-7579-0241 ; 0000-0002-9289-3808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.916$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.916$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33615747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Mee Joo</creatorcontrib><creatorcontrib>Lim, Jiwon</creatorcontrib><creatorcontrib>Han, Sung‐Sik</creatorcontrib><creatorcontrib>Park, Hyeong Min</creatorcontrib><creatorcontrib>Kim, Sun‐Whe</creatorcontrib><creatorcontrib>Won, Young‐Joo</creatorcontrib><creatorcontrib>Park, Sang‐Jae</creatorcontrib><title>Impact of changes in the topographic classification of Klatskin tumor on incidence of intra‐ and extrahepatic bile duct cancer: A population‐based national cancer registry study</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background
Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence of intrahepatic BDC (iBDC). This study aimed to investigate the impact of misclassified Klatskin tumor on iBDC and eBDC incidences in Korea, where BDC is highly endemic.
Methods
The data of incidence, topography and morphology code of BDC from 1999 to 2017 were obtained from the Korea Central Cancer Registry, which covers the entire 51.6 million Korean population. For misclassification analysis, all Klatskin tumors were reclassified as eBDC.
Results
Klatskin tumors accounted for 13.5% of all 81 414 BDC cases. In the registry, an average of 59.7% of Klatskin tumors were classified as iBDC, gradually decreasing from 95.5% to 16.9%. Misclassification led to a 17.3% overestimation of iBDC cases and a 15.0% underestimation of eBDC cases on average. After reclassification, age standardized rate (ASR) of incidence per 100 000 population decreased in iBDC from 3.4 to 2.9 and increased in eBDC from 2.8 to 3.2. Average annual percentage change of iBDC and eBDC incidences were 2.0% and 1.2%, respectively, but ASR of iBDC significantly decreased since 2012 (P < 0.0001).
Conclusions
Misclassification of Klatskin tumors has remarkable impact on the incidence of iBDC and eBDC in a highly endemic country.
Highlight
In cancer registries, Klatskin tumor has not been consistently classified as intra‐ or extrahepatic bile duct cancer over time. Kang and colleagues revealed that changes in topographic classification of Klatskin tumor have led to over‐ and underestimation of the incidence of intra‐ and extrahepatic bile duct cancer, respectively, in Korea.</description><subject>bile duct neoplasms</subject><subject>Bile ducts</subject><subject>Cancer</subject><subject>Cholangiocarcinoma</subject><subject>epidemiology</subject><subject>incidence</subject><subject>Klatskin tumor</subject><subject>Population-based studies</subject><subject>Tumors</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kUtu1TAUhi0EolWpxAqQJSZMUvxI7GtmpQJaqAQDGEcnftz4ktjBTgR3xhLYDBtiJTjtpUhIeGIf-zufZf8IPabkjBLCnu_6bjpTVNxDx3QjNpVQG3b_bi3rI3Sa846UwSlXnDxER5wL2shaHqOfV-MEesbRYd1D2NqMfcBzb_Ecp7hNMPVeYz1Azt55DbOPYYXfDTDnzyu6jDHhsumD9sYGbddjH-YEv77_wBAMtt9K0dupNGvc-cFis5QrNRQ4vcDneIrTMtyoS0sH2RocbkoYDhROduvznPY4z4vZP0IPHAzZnh7mE_Tp9auPF5fV9fs3Vxfn15XmkotKUUfAgBRG045qBoQSx8E2FhrmaqK14o0zSipolOFMaCnLGoijvBPW8RP07NY7pfhlsXluR5-1HQYINi65ZbViTBGyUQV9-g-6i0sqLyhUI4WsWU3ZX6FOMedkXTslP0Lat5S0a5rtmmZb0izok4Nw6UZr7sA_2RWgugW-li_d_1fUvr18-WEV_gYKya6k</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Kang, Mee Joo</creator><creator>Lim, Jiwon</creator><creator>Han, Sung‐Sik</creator><creator>Park, Hyeong Min</creator><creator>Kim, Sun‐Whe</creator><creator>Won, Young‐Joo</creator><creator>Park, Sang‐Jae</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9861-6740</orcidid><orcidid>https://orcid.org/0000-0001-7047-7961</orcidid><orcidid>https://orcid.org/0000-0002-3322-7792</orcidid><orcidid>https://orcid.org/0000-0001-5582-9420</orcidid><orcidid>https://orcid.org/0000-0001-6315-6019</orcidid><orcidid>https://orcid.org/0000-0002-7579-0241</orcidid><orcidid>https://orcid.org/0000-0002-9289-3808</orcidid></search><sort><creationdate>202109</creationdate><title>Impact of changes in the topographic classification of Klatskin tumor on incidence of intra‐ and extrahepatic bile duct cancer: A population‐based national cancer registry study</title><author>Kang, Mee Joo ; Lim, Jiwon ; Han, Sung‐Sik ; Park, Hyeong Min ; Kim, Sun‐Whe ; Won, Young‐Joo ; Park, Sang‐Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3736-91f0ada76dc1b1c2a010f3ae5ea52f40cc935fd979a59d326c7779aa0f13b6ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>bile duct neoplasms</topic><topic>Bile ducts</topic><topic>Cancer</topic><topic>Cholangiocarcinoma</topic><topic>epidemiology</topic><topic>incidence</topic><topic>Klatskin tumor</topic><topic>Population-based studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Mee Joo</creatorcontrib><creatorcontrib>Lim, Jiwon</creatorcontrib><creatorcontrib>Han, Sung‐Sik</creatorcontrib><creatorcontrib>Park, Hyeong Min</creatorcontrib><creatorcontrib>Kim, Sun‐Whe</creatorcontrib><creatorcontrib>Won, Young‐Joo</creatorcontrib><creatorcontrib>Park, Sang‐Jae</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Mee Joo</au><au>Lim, Jiwon</au><au>Han, Sung‐Sik</au><au>Park, Hyeong Min</au><au>Kim, Sun‐Whe</au><au>Won, Young‐Joo</au><au>Park, Sang‐Jae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of changes in the topographic classification of Klatskin tumor on incidence of intra‐ and extrahepatic bile duct cancer: A population‐based national cancer registry study</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2021-09</date><risdate>2021</risdate><volume>28</volume><issue>9</issue><spage>740</spage><epage>750</epage><pages>740-750</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background
Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence of intrahepatic BDC (iBDC). This study aimed to investigate the impact of misclassified Klatskin tumor on iBDC and eBDC incidences in Korea, where BDC is highly endemic.
Methods
The data of incidence, topography and morphology code of BDC from 1999 to 2017 were obtained from the Korea Central Cancer Registry, which covers the entire 51.6 million Korean population. For misclassification analysis, all Klatskin tumors were reclassified as eBDC.
Results
Klatskin tumors accounted for 13.5% of all 81 414 BDC cases. In the registry, an average of 59.7% of Klatskin tumors were classified as iBDC, gradually decreasing from 95.5% to 16.9%. Misclassification led to a 17.3% overestimation of iBDC cases and a 15.0% underestimation of eBDC cases on average. After reclassification, age standardized rate (ASR) of incidence per 100 000 population decreased in iBDC from 3.4 to 2.9 and increased in eBDC from 2.8 to 3.2. Average annual percentage change of iBDC and eBDC incidences were 2.0% and 1.2%, respectively, but ASR of iBDC significantly decreased since 2012 (P < 0.0001).
Conclusions
Misclassification of Klatskin tumors has remarkable impact on the incidence of iBDC and eBDC in a highly endemic country.
Highlight
In cancer registries, Klatskin tumor has not been consistently classified as intra‐ or extrahepatic bile duct cancer over time. Kang and colleagues revealed that changes in topographic classification of Klatskin tumor have led to over‐ and underestimation of the incidence of intra‐ and extrahepatic bile duct cancer, respectively, in Korea.</abstract><cop>Japan</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33615747</pmid><doi>10.1002/jhbp.916</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9861-6740</orcidid><orcidid>https://orcid.org/0000-0001-7047-7961</orcidid><orcidid>https://orcid.org/0000-0002-3322-7792</orcidid><orcidid>https://orcid.org/0000-0001-5582-9420</orcidid><orcidid>https://orcid.org/0000-0001-6315-6019</orcidid><orcidid>https://orcid.org/0000-0002-7579-0241</orcidid><orcidid>https://orcid.org/0000-0002-9289-3808</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | bile duct neoplasms Bile ducts Cancer Cholangiocarcinoma epidemiology incidence Klatskin tumor Population-based studies Tumors |
| title | Impact of changes in the topographic classification of Klatskin tumor on incidence of intra‐ and extrahepatic bile duct cancer: A population‐based national cancer registry study |
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