Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1

Aims Diabetic nephropathy (DN) is a leading cause of end‐stage renal disease. BASP1 (brain acid‐soluble protein) is up‐regulated in podocyte‐specific protein phosphatase 2A knockout mice (Pod‐PP2A‐KO) that develop kidney dysfunction. Here, we explore the role of BASP1 for podocytes in DN. Methods BA...

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Veröffentlicht in:	Acta Physiologica 2021-05, Vol.232 (1), p.e13634-n/a
Hauptverfasser:	Zhang, Yingying, Xu, Chengxian, Ye, Qing, Tong, Lingxiao, Jiang, Hong, Zhu, Xiujuan, Huang, Limin, Lin, Weiqiang, Fu, Haidong, Wang, Jingjing, Persson, Pontus B., Lai, En Yin, Mao, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animal models Apoptosis BASP1 Cytoskeleton Diabetes Diabetes mellitus Diabetic nephropathy Kidney diseases Nephropathy p53 p53 Protein Phosphoprotein phosphatase podocyte Protein phosphatase Rodents Signal transduction Tumors
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