An insight into the anticancer potential of carbamates and thiocarbamates of 10-demethoxy-10-methylaminocolchicine

Colchicine shows very high antimitotic activity, therefore, it is used as a lead compound for generation of new anticancer agents. In the hope of developing novel, useful drugs with more favourable pharmacological profiles, a series of doubly modified colchicine derivatives has been designed, synthe...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-04, Vol.215, p.113282-113282, Article 113282
Hauptverfasser:	Krzywik, Julia, Aminpour, Maral, Janczak, Jan, Maj, Ewa, Moshari, Mahshad, Mozga, Witold, Wietrzyk, Joanna, Tuszyński, Jack A., Huczyński, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agents Carbamate Crystal structure Docking studies QSAR Thiocarbamate Tubulin inhibitors
Online-Zugang:	Volltext
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