Development of a risk prediction model for early discrimination between permanent and transient congenital hypothyroidism

Objective To develop a risk prediction model for early discrimination between transient and permanent congenital hypothyroidism (CH). Design and setting In a retrospective cohort, 1047 confirmed CH neonates, from 15 randomly selected provinces in Iran, were entered to the study. Clinical and biochemical information of transient and permanent cases, distinct at the age of 3 years were retrospectively gathered. Results Among CH neonates, the overall prevalence of permanent CH was 57.1%. Using forward stepwise multivariable logistic regression analysis, confirmatory venous TSH, total T4