Inflammasomes and adaptive immune responses
A fundamental concept in immunology is that the innate immune system initiates or instructs downstream adaptive immune responses. Inflammasomes are central players in innate immunity to pathogens, but how inflammasomes shape adaptive immunity is complex and relatively poorly understood. Here we high...
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| Veröffentlicht in: | Nature immunology 2021-04, Vol.22 (4), p.412-422 |
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| container_title | Nature immunology |
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| creator | Deets, Katherine A. Vance, Russell E. |
| description | A fundamental concept in immunology is that the innate immune system initiates or instructs downstream adaptive immune responses. Inflammasomes are central players in innate immunity to pathogens, but how inflammasomes shape adaptive immunity is complex and relatively poorly understood. Here we highlight recent work on the interplay between inflammasomes and adaptive immunity. We address how inflammasome-dependent release of cytokines and antigen activates, shapes or even inhibits adaptive immune responses. We consider how distinct tissue or cellular contexts may alter the effects of inflammasome activation on adaptive immunity and how this contributes to beneficial or detrimental outcomes in infectious diseases, cancer and autoimmunity. We aspire to provide a framework for thinking about inflammasomes and their connection to the adaptive immune response.
Deets and Vance discuss the influence of inflammasome activation on adaptive immunity. |
| doi_str_mv | 10.1038/s41590-021-00869-6 |
| format | Article |
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Deets and Vance discuss the influence of inflammasome activation on adaptive immunity.</description><subject>631/250/2152/1566/1618</subject><subject>631/250/262/2106/2517</subject><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>Antigen-antibody reactions</subject><subject>Antigens - immunology</subject><subject>Antigens - metabolism</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Autoimmunity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Communicable Diseases - immunology</subject><subject>Communicable Diseases - metabolism</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Inflammasomes</subject><subject>Inflammasomes - immunology</subject><subject>Inflammasomes - metabolism</subject><subject>Innate immunity</subject><subject>Interferon</subject><subject>Lymphocyte Activation</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - metabolism</subject><subject>Pyroptosis</subject><subject>Review Article</subject><subject>Signal Transduction</subject><subject>Vaccination</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVtr3DAQhUVJadI0fyAPYSEvLcXp6GZJjyH0shAotM2z0NrjxcGSNxo7tP--2m6asKUEPUiMvnNmhsPYKYcLDtJ-IMW1gwoErwBs7ar6BTviWrhKOF4fPL7BHrLXRLcAXJlavWKHUtYghTBH7P0ydUOIMdAYkRYhtYvQhs3U3-Oij3FOuMhImzER0hv2sgsD4cnDfcxuPn38cfWluv76eXl1eV01xX6qgnGrttHWtABCOIcrpWWQAkTp6kTXQggIDtGujBaN1aLjwTqLSnZCCS2P2dud7yaPdzPS5GNPDQ5DSDjO5IVy3CmnQBX0_B_0dpxzKtN5ocFY0MaZJ2odBvR96sYph2Zr6i9rbcAaB9u2F_-hymkx9s2YsOtLfU_wbk9QmAl_TuswE_nl92_7rNixTR6JMnZ-k_sY8i_PwW_T9Ls0fUnT_0nT10V09rDdvIrYPkr-xlcAuQOofKU15qf1n7H9Dcu8pWk</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Deets, Katherine A.</creator><creator>Vance, Russell E.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6686-3912</orcidid></search><sort><creationdate>20210401</creationdate><title>Inflammasomes and adaptive immune responses</title><author>Deets, Katherine A. ; Vance, Russell E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-a79bdc587d002299eb453a320236092fd0aae09ee8b752c852f1a898e43f24253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/250/2152/1566/1618</topic><topic>631/250/262/2106/2517</topic><topic>Adaptive Immunity</topic><topic>Animals</topic><topic>Antigen-antibody reactions</topic><topic>Antigens - immunology</topic><topic>Antigens - metabolism</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Autoimmunity</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Communicable Diseases - immunology</topic><topic>Communicable Diseases - metabolism</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Inflammasomes</topic><topic>Inflammasomes - immunology</topic><topic>Inflammasomes - metabolism</topic><topic>Innate immunity</topic><topic>Interferon</topic><topic>Lymphocyte Activation</topic><topic>Neoplasms - 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deets, Katherine A.</au><au>Vance, Russell E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammasomes and adaptive immune responses</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>22</volume><issue>4</issue><spage>412</spage><epage>422</epage><pages>412-422</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>A fundamental concept in immunology is that the innate immune system initiates or instructs downstream adaptive immune responses. Inflammasomes are central players in innate immunity to pathogens, but how inflammasomes shape adaptive immunity is complex and relatively poorly understood. Here we highlight recent work on the interplay between inflammasomes and adaptive immunity. We address how inflammasome-dependent release of cytokines and antigen activates, shapes or even inhibits adaptive immune responses. We consider how distinct tissue or cellular contexts may alter the effects of inflammasome activation on adaptive immunity and how this contributes to beneficial or detrimental outcomes in infectious diseases, cancer and autoimmunity. We aspire to provide a framework for thinking about inflammasomes and their connection to the adaptive immune response.
Deets and Vance discuss the influence of inflammasome activation on adaptive immunity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33603227</pmid><doi>10.1038/s41590-021-00869-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6686-3912</orcidid></addata></record> |
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| subjects | 631/250/2152/1566/1618 631/250/262/2106/2517 Adaptive Immunity Animals Antigen-antibody reactions Antigens - immunology Antigens - metabolism Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmunity Biomedical and Life Sciences Biomedicine CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Communicable Diseases - immunology Communicable Diseases - metabolism Cytokines Cytokines - immunology Cytokines - metabolism Genetic aspects Genetic research Humans Immune response Immune system Immunology Infectious Diseases Inflammasomes Inflammasomes - immunology Inflammasomes - metabolism Innate immunity Interferon Lymphocyte Activation Neoplasms - immunology Neoplasms - metabolism Pyroptosis Review Article Signal Transduction Vaccination |
| title | Inflammasomes and adaptive immune responses |
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