Intrinsic Disruption of the M1 Cortical Network in a Mouse Model of Parkinson's Disease

ABSTRACT Background Parkinson's disease (PD) disrupts motor performance by affecting the basal ganglia system. Yet, despite the critical position of the primary motor cortex in linking basal ganglia computations with motor performance, its contribution to motor disability in PD is largely unkno...

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Veröffentlicht in:	Movement disorders 2021-07, Vol.36 (7), p.1565-1577
Hauptverfasser:	Aeed, Fadi, Cermak, Nathan, Schiller, Jackie, Schiller, Yitzhak
Format:	Artikel
Sprache:	eng
Schlagworte:	Basal ganglia Calcium imaging Central nervous system diseases Cortex (motor) Cortex (temporal) Motor task performance Movement disorders network dynamics Neurodegenerative diseases Neuroimaging Parkinson's disease Population dynamics primary motor cortex Pyramidal cells pyramidal tract neurons
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