Endogenous production of n−3 polyunsaturated fatty acids protects mice from carbon tetrachloride‐induced liver fibrosis by regulating mTOR and Bcl‐2/Bax signalling pathways

New Findings What is the central question of this study? What is the protective benefit of n−3 polyunsaturated fatty acids (PUFAs) on liver fibrosis and what are the relevant signalling pathways in a transgenic mouse model overexpressing the mfat‐1 enzyme? What is the main finding and its importance...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental physiology 2021-04, Vol.106 (4), p.983-993
Hauptverfasser:	Shan, Changfeng, Wang, Ronghua, Wang, Shuai, Zhang, Zongmeng, Xing, Chaofeng, Feng, Wenbin, Zhao, Zhenggang, Zhou, Sujin, Zhao, Allan Zijian, Mu, Yunping, Li, Fanghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animals Aspartate aminotransferase BAX protein bcl-2-Associated X Protein - metabolism Bcl-x protein Bcl‐2/Bax Bile Carbon tetrachloride Carbon Tetrachloride - adverse effects Carbon Tetrachloride - metabolism CCL4 protein Cell culture Collagen Docosahexaenoic acid Extracellular matrix Fatty acids Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - pharmacology Fibrosis Gene therapy hepatic stellate cells Inflammation Liver Liver - metabolism Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy Liver Cirrhosis - prevention & control liver fibrosis Lymphoma Male Mice Mice, Inbred C57BL mTOR n−3 PUFAs Polyunsaturated fatty acids Proteins Rapamycin Signal transduction Stellate cells TOR protein TOR Serine-Threonine Kinases - metabolism Transgenic animals transgenic mfat‐1 mice Transgenic mice Wound healing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!