Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms
Purpose To investigate the magnitude and time course of pseudorandom ffERG during light adaptation. Methods Ten healthy subjects (26 ± 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m 2 ) driven by m-sequences (2...
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| creator | Assis, Juliana Bizerra Brasil, Alódia Loureiro, Terezinha Medeiros Gonçalves da Silva, Veronica Gabriela Ribeiro Herculano, Anderson Manoel Ventura, Dora Fix Silveira, Luiz Carlos Lima Kremers, Jan Souza, Givago Silva |
| description | Purpose
To investigate the magnitude and time course of pseudorandom ffERG during light adaptation.
Methods
Ten healthy subjects (26 ± 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m
2
) driven by m-sequences (2
10
–1 stimulus steps) using Veris Science software and a Ganzfeld dome over a constant field of light adaptation (30 cd/m
2
). The base period of the m-sequence was 50 ms. Each stimulation sequence lasting 40 s was repeated at 0, 5, 10, 15 and 20 min of light adaptation. Relative amplitude and latency (corrected by values found at 0 min) of the three components (N1, P1, and N2) of first-order (K
1
) and first slice of the second-order (K
2.1
) kernel at 5 time points were evaluated. An exponential model was fitted to the mean amplitude and latency data as a function of the light adaptation duration to estimate the time course (
τ
) of the light adaptation for each component. Repeated one-way ANOVA followed by Tukey post-test was applied to the amplitude and latency data, considering significant values of
p
|
| doi_str_mv | 10.1007/s10633-021-09822-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2491947029</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2491947029</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-feea9219daf711446e1bb73c0afa46d02f7b993c41152495618198ad8eefbe713</originalsourceid><addsrcrecordid>eNp9kMFu1TAQRS0Eoq-FH2CBIrFhY-oZO3a8RFWhSJXogkrsLCcev6ZK4oedLPh73L4CEgtWlsbn3rEPY29AfAAhzHkBoaXkAoEL2yFyfMZ20BrJUSM-ZzshALlSnT5hp6XcCyGsge4lO5FSCw0Sd-z7TaEtpOyXkOYmbtPE40hTaGiiYc0p0zouaZ_9XJpM8WHYhDFGyrSszTTu79bGB39Y_TqmpZlpuPPLWObyir2Ifir0-uk8Y7efLr9dXPHrr5-_XHy85oNEvfJI5C2CDT4aAKU0Qd8bOQgfvdJBYDS9tXJQAC0q22rowHY-dESxJwPyjL0_9h5y-rFRWd08loGmyS-UtuJqCKwyAm1F3_2D3qctL_V1DltVIdNaVSk8UkNOpdQ_u0MeZ59_OhDuwbs7enfVu3v07rCG3j5Vb_1M4U_kt-gKyCNQ6tWyp_x3939qfwFVNI6j</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2549477594</pqid></control><display><type>article</type><title>Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Assis, Juliana Bizerra ; Brasil, Alódia ; Loureiro, Terezinha Medeiros Gonçalves ; da Silva, Veronica Gabriela Ribeiro ; Herculano, Anderson Manoel ; Ventura, Dora Fix ; Silveira, Luiz Carlos Lima ; Kremers, Jan ; Souza, Givago Silva</creator><creatorcontrib>Assis, Juliana Bizerra ; Brasil, Alódia ; Loureiro, Terezinha Medeiros Gonçalves ; da Silva, Veronica Gabriela Ribeiro ; Herculano, Anderson Manoel ; Ventura, Dora Fix ; Silveira, Luiz Carlos Lima ; Kremers, Jan ; Souza, Givago Silva</creatorcontrib><description>Purpose
To investigate the magnitude and time course of pseudorandom ffERG during light adaptation.
Methods
Ten healthy subjects (26 ± 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m
2
) driven by m-sequences (2
10
–1 stimulus steps) using Veris Science software and a Ganzfeld dome over a constant field of light adaptation (30 cd/m
2
). The base period of the m-sequence was 50 ms. Each stimulation sequence lasting 40 s was repeated at 0, 5, 10, 15 and 20 min of light adaptation. Relative amplitude and latency (corrected by values found at 0 min) of the three components (N1, P1, and N2) of first-order (K
1
) and first slice of the second-order (K
2.1
) kernel at 5 time points were evaluated. An exponential model was fitted to the mean amplitude and latency data as a function of the light adaptation duration to estimate the time course (
τ
) of the light adaptation for each component. Repeated one-way ANOVA followed by Tukey post-test was applied to the amplitude and latency data, considering significant values of
p
< 0.05.
Results
Regarding the K
1
ffERG, N1 K
1
, P1 K
1
, and N2 K
1
presented an amplitude increase as a function of the light adaptation (N1 K
1
τ
value = 2.66 min ± 4.2; P1 K
1
τ
value = 2.69 min ± 2.10; and N2 K
1
τ value = 3.49 min ± 2.96). P1 K
1
and N2 K
1
implicit time changed as a function of the light adaptation duration (P1 K
1
τ
value = 3.61 min ± 5.2; N2 K
1
τ
value = 3.25 min ± 4.8). N1 K
1
had small implicit time changes during the light adaptation. All the K
2,1
components also had nonsignificant changes in amplitude and implicit time during the light adaptation.
Conclusions
Pseudorandom ffERGs showed different mechanisms of adaptation to retinal light. Our results suggest that K
1
ffERG is generated by retinal mechanisms with intermediate- to long-term light adaptation, while K
2.1
ffERG is generated by retinal mechanism with fast light adaptation course.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/s10633-021-09822-2</identifier><identifier>PMID: 33606132</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adaptation, Ocular ; Auditory evoked potentials ; Dark Adaptation ; Electroretinograms ; Electroretinography ; Healthy Volunteers ; Humans ; Latency ; Light ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Research Article ; Photic Stimulation ; Retina ; Temperature</subject><ispartof>Documenta ophthalmologica, 2021-08, Vol.143 (1), p.53-60</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-feea9219daf711446e1bb73c0afa46d02f7b993c41152495618198ad8eefbe713</cites><orcidid>0000-0001-7195-9305</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10633-021-09822-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10633-021-09822-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33606132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Assis, Juliana Bizerra</creatorcontrib><creatorcontrib>Brasil, Alódia</creatorcontrib><creatorcontrib>Loureiro, Terezinha Medeiros Gonçalves</creatorcontrib><creatorcontrib>da Silva, Veronica Gabriela Ribeiro</creatorcontrib><creatorcontrib>Herculano, Anderson Manoel</creatorcontrib><creatorcontrib>Ventura, Dora Fix</creatorcontrib><creatorcontrib>Silveira, Luiz Carlos Lima</creatorcontrib><creatorcontrib>Kremers, Jan</creatorcontrib><creatorcontrib>Souza, Givago Silva</creatorcontrib><title>Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms</title><title>Documenta ophthalmologica</title><addtitle>Doc Ophthalmol</addtitle><addtitle>Doc Ophthalmol</addtitle><description>Purpose
To investigate the magnitude and time course of pseudorandom ffERG during light adaptation.
Methods
Ten healthy subjects (26 ± 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m
2
) driven by m-sequences (2
10
–1 stimulus steps) using Veris Science software and a Ganzfeld dome over a constant field of light adaptation (30 cd/m
2
). The base period of the m-sequence was 50 ms. Each stimulation sequence lasting 40 s was repeated at 0, 5, 10, 15 and 20 min of light adaptation. Relative amplitude and latency (corrected by values found at 0 min) of the three components (N1, P1, and N2) of first-order (K
1
) and first slice of the second-order (K
2.1
) kernel at 5 time points were evaluated. An exponential model was fitted to the mean amplitude and latency data as a function of the light adaptation duration to estimate the time course (
τ
) of the light adaptation for each component. Repeated one-way ANOVA followed by Tukey post-test was applied to the amplitude and latency data, considering significant values of
p
< 0.05.
Results
Regarding the K
1
ffERG, N1 K
1
, P1 K
1
, and N2 K
1
presented an amplitude increase as a function of the light adaptation (N1 K
1
τ
value = 2.66 min ± 4.2; P1 K
1
τ
value = 2.69 min ± 2.10; and N2 K
1
τ value = 3.49 min ± 2.96). P1 K
1
and N2 K
1
implicit time changed as a function of the light adaptation duration (P1 K
1
τ
value = 3.61 min ± 5.2; N2 K
1
τ
value = 3.25 min ± 4.8). N1 K
1
had small implicit time changes during the light adaptation. All the K
2,1
components also had nonsignificant changes in amplitude and implicit time during the light adaptation.
Conclusions
Pseudorandom ffERGs showed different mechanisms of adaptation to retinal light. Our results suggest that K
1
ffERG is generated by retinal mechanisms with intermediate- to long-term light adaptation, while K
2.1
ffERG is generated by retinal mechanism with fast light adaptation course.</description><subject>Adaptation, Ocular</subject><subject>Auditory evoked potentials</subject><subject>Dark Adaptation</subject><subject>Electroretinograms</subject><subject>Electroretinography</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Latency</subject><subject>Light</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Research Article</subject><subject>Photic Stimulation</subject><subject>Retina</subject><subject>Temperature</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMFu1TAQRS0Eoq-FH2CBIrFhY-oZO3a8RFWhSJXogkrsLCcev6ZK4oedLPh73L4CEgtWlsbn3rEPY29AfAAhzHkBoaXkAoEL2yFyfMZ20BrJUSM-ZzshALlSnT5hp6XcCyGsge4lO5FSCw0Sd-z7TaEtpOyXkOYmbtPE40hTaGiiYc0p0zouaZ_9XJpM8WHYhDFGyrSszTTu79bGB39Y_TqmpZlpuPPLWObyir2Ifir0-uk8Y7efLr9dXPHrr5-_XHy85oNEvfJI5C2CDT4aAKU0Qd8bOQgfvdJBYDS9tXJQAC0q22rowHY-dESxJwPyjL0_9h5y-rFRWd08loGmyS-UtuJqCKwyAm1F3_2D3qctL_V1DltVIdNaVSk8UkNOpdQ_u0MeZ59_OhDuwbs7enfVu3v07rCG3j5Vb_1M4U_kt-gKyCNQ6tWyp_x3939qfwFVNI6j</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Assis, Juliana Bizerra</creator><creator>Brasil, Alódia</creator><creator>Loureiro, Terezinha Medeiros Gonçalves</creator><creator>da Silva, Veronica Gabriela Ribeiro</creator><creator>Herculano, Anderson Manoel</creator><creator>Ventura, Dora Fix</creator><creator>Silveira, Luiz Carlos Lima</creator><creator>Kremers, Jan</creator><creator>Souza, Givago Silva</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7195-9305</orcidid></search><sort><creationdate>20210801</creationdate><title>Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms</title><author>Assis, Juliana Bizerra ; Brasil, Alódia ; Loureiro, Terezinha Medeiros Gonçalves ; da Silva, Veronica Gabriela Ribeiro ; Herculano, Anderson Manoel ; Ventura, Dora Fix ; Silveira, Luiz Carlos Lima ; Kremers, Jan ; Souza, Givago Silva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-feea9219daf711446e1bb73c0afa46d02f7b993c41152495618198ad8eefbe713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptation, Ocular</topic><topic>Auditory evoked potentials</topic><topic>Dark Adaptation</topic><topic>Electroretinograms</topic><topic>Electroretinography</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Latency</topic><topic>Light</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Research Article</topic><topic>Photic Stimulation</topic><topic>Retina</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Assis, Juliana Bizerra</creatorcontrib><creatorcontrib>Brasil, Alódia</creatorcontrib><creatorcontrib>Loureiro, Terezinha Medeiros Gonçalves</creatorcontrib><creatorcontrib>da Silva, Veronica Gabriela Ribeiro</creatorcontrib><creatorcontrib>Herculano, Anderson Manoel</creatorcontrib><creatorcontrib>Ventura, Dora Fix</creatorcontrib><creatorcontrib>Silveira, Luiz Carlos Lima</creatorcontrib><creatorcontrib>Kremers, Jan</creatorcontrib><creatorcontrib>Souza, Givago Silva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Assis, Juliana Bizerra</au><au>Brasil, Alódia</au><au>Loureiro, Terezinha Medeiros Gonçalves</au><au>da Silva, Veronica Gabriela Ribeiro</au><au>Herculano, Anderson Manoel</au><au>Ventura, Dora Fix</au><au>Silveira, Luiz Carlos Lima</au><au>Kremers, Jan</au><au>Souza, Givago Silva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms</atitle><jtitle>Documenta ophthalmologica</jtitle><stitle>Doc Ophthalmol</stitle><addtitle>Doc Ophthalmol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>143</volume><issue>1</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0012-4486</issn><eissn>1573-2622</eissn><abstract>Purpose
To investigate the magnitude and time course of pseudorandom ffERG during light adaptation.
Methods
Ten healthy subjects (26 ± 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m
2
) driven by m-sequences (2
10
–1 stimulus steps) using Veris Science software and a Ganzfeld dome over a constant field of light adaptation (30 cd/m
2
). The base period of the m-sequence was 50 ms. Each stimulation sequence lasting 40 s was repeated at 0, 5, 10, 15 and 20 min of light adaptation. Relative amplitude and latency (corrected by values found at 0 min) of the three components (N1, P1, and N2) of first-order (K
1
) and first slice of the second-order (K
2.1
) kernel at 5 time points were evaluated. An exponential model was fitted to the mean amplitude and latency data as a function of the light adaptation duration to estimate the time course (
τ
) of the light adaptation for each component. Repeated one-way ANOVA followed by Tukey post-test was applied to the amplitude and latency data, considering significant values of
p
< 0.05.
Results
Regarding the K
1
ffERG, N1 K
1
, P1 K
1
, and N2 K
1
presented an amplitude increase as a function of the light adaptation (N1 K
1
τ
value = 2.66 min ± 4.2; P1 K
1
τ
value = 2.69 min ± 2.10; and N2 K
1
τ value = 3.49 min ± 2.96). P1 K
1
and N2 K
1
implicit time changed as a function of the light adaptation duration (P1 K
1
τ
value = 3.61 min ± 5.2; N2 K
1
τ
value = 3.25 min ± 4.8). N1 K
1
had small implicit time changes during the light adaptation. All the K
2,1
components also had nonsignificant changes in amplitude and implicit time during the light adaptation.
Conclusions
Pseudorandom ffERGs showed different mechanisms of adaptation to retinal light. Our results suggest that K
1
ffERG is generated by retinal mechanisms with intermediate- to long-term light adaptation, while K
2.1
ffERG is generated by retinal mechanism with fast light adaptation course.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33606132</pmid><doi>10.1007/s10633-021-09822-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7195-9305</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-4486 |
| ispartof | Documenta ophthalmologica, 2021-08, Vol.143 (1), p.53-60 |
| issn | 0012-4486 1573-2622 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2491947029 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adaptation, Ocular Auditory evoked potentials Dark Adaptation Electroretinograms Electroretinography Healthy Volunteers Humans Latency Light Medicine Medicine & Public Health Ophthalmology Original Research Article Photic Stimulation Retina Temperature |
| title | Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms |
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