Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis
•Skin autofluorescence indicates advanced glycation end products and oxidative stress.•Mortality in affective disorders is partially mediated by increased skin autofluorescence.•For major depression, the mediating effect was strongest and independent of covariates.•Skin autofluorescence was consiste...
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| Veröffentlicht in: | Journal of affective disorders 2021-03, Vol.282, p.1082-1089 |
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| container_title | Journal of affective disorders |
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| creator | Hagen, Julia M. Sutterland, Arjen L. Liefers, Tessa Schirmbeck, Frederike Cohn, Danny M. Lok, Anja Tan, Hanno L. Zwinderman, Aeilko H. de Haan, Lieuwe |
| description | •Skin autofluorescence indicates advanced glycation end products and oxidative stress.•Mortality in affective disorders is partially mediated by increased skin autofluorescence.•For major depression, the mediating effect was strongest and independent of covariates.•Skin autofluorescence was consistently and independently associated with mortality.
Life expectancy in patients suffering from affective disorders is considerably diminished. We investigated whether skin autofluorescence (SAF), indicating concentration of advanced glycation end products in the skin and oxidative stress, mediates the association between affective disorders and excess mortality.
Included were 81,041 participants of the Lifelines cohort study. Presence of major depressive disorder, dysthymia, generalised anxiety disorder, panic disorder or social phobia was assessed with the Mini-International Neuropsychiatric Interview. SAF was assessed as mediator in Cox proportional hazards models for all-cause or natural-cause mortality.
Mortality was increased in cases with major depression compared to controls (36.4 vs. 22.5 per 100,000 person years). Partial mediation by SAF of the association between affective disorders and mortality was shown (9.0-10.5%, P |
| doi_str_mv | 10.1016/j.jad.2020.12.202 |
| format | Article |
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Life expectancy in patients suffering from affective disorders is considerably diminished. We investigated whether skin autofluorescence (SAF), indicating concentration of advanced glycation end products in the skin and oxidative stress, mediates the association between affective disorders and excess mortality.
Included were 81,041 participants of the Lifelines cohort study. Presence of major depressive disorder, dysthymia, generalised anxiety disorder, panic disorder or social phobia was assessed with the Mini-International Neuropsychiatric Interview. SAF was assessed as mediator in Cox proportional hazards models for all-cause or natural-cause mortality.
Mortality was increased in cases with major depression compared to controls (36.4 vs. 22.5 per 100,000 person years). Partial mediation by SAF of the association between affective disorders and mortality was shown (9.0-10.5%, P<.001-.002), although attenuated by cardiometabolic parameters and history of physical illness. For major depressive disorder, partial mediation by 5.5-10.3% was shown (crude model: P<.001; fully adjusted model: P=.03).
The relatively short duration of follow-up and the relatively young cohort resulted in a lack of power to detect an association between mortality and dysthymia, social phobia and two or more comorbid disorders.
Evidence of partial mediation by SAF of the association between affective disorders and all-cause and natural-cause mortality was demonstrated, although attenuated by health factors. For major depression, mediation by SAF was largest and remained significant after adjustment for sociodemographic and health factors, identifying oxidative stress as possible determinant of premature death.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2020.12.202</identifier><identifier>PMID: 33601681</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Advanced glycation end products ; Anxiety disorders ; Cohort Studies ; Depressive Disorder, Major - epidemiology ; Depressive Disorder, Major - mortality ; Fluorescence ; Glycation End Products, Advanced ; Humans ; Mediation Analysis ; Mood Disorders ; Mortality ; Oxidative stress ; Skin</subject><ispartof>Journal of affective disorders, 2021-03, Vol.282, p.1082-1089</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-c5d67d5d0944c624048ccedd1b2e35ed71cfaca31eee4fc9be44bfe263044cc93</citedby><cites>FETCH-LOGICAL-c396t-c5d67d5d0944c624048ccedd1b2e35ed71cfaca31eee4fc9be44bfe263044cc93</cites><orcidid>0000-0002-5085-1108 ; 0000-0003-0361-3139</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2020.12.202$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33601681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagen, Julia M.</creatorcontrib><creatorcontrib>Sutterland, Arjen L.</creatorcontrib><creatorcontrib>Liefers, Tessa</creatorcontrib><creatorcontrib>Schirmbeck, Frederike</creatorcontrib><creatorcontrib>Cohn, Danny M.</creatorcontrib><creatorcontrib>Lok, Anja</creatorcontrib><creatorcontrib>Tan, Hanno L.</creatorcontrib><creatorcontrib>Zwinderman, Aeilko H.</creatorcontrib><creatorcontrib>de Haan, Lieuwe</creatorcontrib><title>Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>•Skin autofluorescence indicates advanced glycation end products and oxidative stress.•Mortality in affective disorders is partially mediated by increased skin autofluorescence.•For major depression, the mediating effect was strongest and independent of covariates.•Skin autofluorescence was consistently and independently associated with mortality.
Life expectancy in patients suffering from affective disorders is considerably diminished. We investigated whether skin autofluorescence (SAF), indicating concentration of advanced glycation end products in the skin and oxidative stress, mediates the association between affective disorders and excess mortality.
Included were 81,041 participants of the Lifelines cohort study. Presence of major depressive disorder, dysthymia, generalised anxiety disorder, panic disorder or social phobia was assessed with the Mini-International Neuropsychiatric Interview. SAF was assessed as mediator in Cox proportional hazards models for all-cause or natural-cause mortality.
Mortality was increased in cases with major depression compared to controls (36.4 vs. 22.5 per 100,000 person years). Partial mediation by SAF of the association between affective disorders and mortality was shown (9.0-10.5%, P<.001-.002), although attenuated by cardiometabolic parameters and history of physical illness. For major depressive disorder, partial mediation by 5.5-10.3% was shown (crude model: P<.001; fully adjusted model: P=.03).
The relatively short duration of follow-up and the relatively young cohort resulted in a lack of power to detect an association between mortality and dysthymia, social phobia and two or more comorbid disorders.
Evidence of partial mediation by SAF of the association between affective disorders and all-cause and natural-cause mortality was demonstrated, although attenuated by health factors. For major depression, mediation by SAF was largest and remained significant after adjustment for sociodemographic and health factors, identifying oxidative stress as possible determinant of premature death.</description><subject>Advanced glycation end products</subject><subject>Anxiety disorders</subject><subject>Cohort Studies</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Depressive Disorder, Major - mortality</subject><subject>Fluorescence</subject><subject>Glycation End Products, Advanced</subject><subject>Humans</subject><subject>Mediation Analysis</subject><subject>Mood Disorders</subject><subject>Mortality</subject><subject>Oxidative stress</subject><subject>Skin</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU2PFCEUJEbjzq7-AC-Go5ce-Wp6Wk-bjbomm3hQz4SBh8vINCvQk_TP8B_7OrN69FQ8qKpQ9Qh5xdmWM67fHrYH67eCCZzFik_IhveD7ETPh6dkg5y-Y1IMF-Sy1gNjTI8De04upNT4tuMb8vvrzzhRO7cc0pwLVAeTA5oDtf5k8ejpj7Q422KeKEyePpTsZ9cqtTgcc2k2xbbQ1SQEcC2egPpYc_FQ6nrd7oGmGCDFCSp1-R41tLbZL-_oNT2Cj2dzO9m01FhfkGfBpgovH_GKfP_44dvNbXf35dPnm-u7zslRt871Xg--92xUymmhmNo5_K3newGyBz9wF6yzkgOACm7cg1L7AEJLhgI3yivy5uyLiX7NUJs5Rkyfkp0gz9UINfJR6XGnkcrPVFdyrQWCeSjxaMtiODPrJszB4CbMugnDxYqoef1oP-8x5D_F3-qR8P5MAAx5ilBMdXEt38eCPRqf43_s_wAKrp1_</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Hagen, Julia M.</creator><creator>Sutterland, Arjen L.</creator><creator>Liefers, Tessa</creator><creator>Schirmbeck, Frederike</creator><creator>Cohn, Danny M.</creator><creator>Lok, Anja</creator><creator>Tan, Hanno L.</creator><creator>Zwinderman, Aeilko H.</creator><creator>de Haan, Lieuwe</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5085-1108</orcidid><orcidid>https://orcid.org/0000-0003-0361-3139</orcidid></search><sort><creationdate>20210301</creationdate><title>Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis</title><author>Hagen, Julia M. ; Sutterland, Arjen L. ; Liefers, Tessa ; Schirmbeck, Frederike ; Cohn, Danny M. ; Lok, Anja ; Tan, Hanno L. ; Zwinderman, Aeilko H. ; de Haan, Lieuwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c5d67d5d0944c624048ccedd1b2e35ed71cfaca31eee4fc9be44bfe263044cc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Advanced glycation end products</topic><topic>Anxiety disorders</topic><topic>Cohort Studies</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Depressive Disorder, Major - mortality</topic><topic>Fluorescence</topic><topic>Glycation End Products, Advanced</topic><topic>Humans</topic><topic>Mediation Analysis</topic><topic>Mood Disorders</topic><topic>Mortality</topic><topic>Oxidative stress</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagen, Julia M.</creatorcontrib><creatorcontrib>Sutterland, Arjen L.</creatorcontrib><creatorcontrib>Liefers, Tessa</creatorcontrib><creatorcontrib>Schirmbeck, Frederike</creatorcontrib><creatorcontrib>Cohn, Danny M.</creatorcontrib><creatorcontrib>Lok, Anja</creatorcontrib><creatorcontrib>Tan, Hanno L.</creatorcontrib><creatorcontrib>Zwinderman, Aeilko H.</creatorcontrib><creatorcontrib>de Haan, Lieuwe</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagen, Julia M.</au><au>Sutterland, Arjen L.</au><au>Liefers, Tessa</au><au>Schirmbeck, Frederike</au><au>Cohn, Danny M.</au><au>Lok, Anja</au><au>Tan, Hanno L.</au><au>Zwinderman, Aeilko H.</au><au>de Haan, Lieuwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>282</volume><spage>1082</spage><epage>1089</epage><pages>1082-1089</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•Skin autofluorescence indicates advanced glycation end products and oxidative stress.•Mortality in affective disorders is partially mediated by increased skin autofluorescence.•For major depression, the mediating effect was strongest and independent of covariates.•Skin autofluorescence was consistently and independently associated with mortality.
Life expectancy in patients suffering from affective disorders is considerably diminished. We investigated whether skin autofluorescence (SAF), indicating concentration of advanced glycation end products in the skin and oxidative stress, mediates the association between affective disorders and excess mortality.
Included were 81,041 participants of the Lifelines cohort study. Presence of major depressive disorder, dysthymia, generalised anxiety disorder, panic disorder or social phobia was assessed with the Mini-International Neuropsychiatric Interview. SAF was assessed as mediator in Cox proportional hazards models for all-cause or natural-cause mortality.
Mortality was increased in cases with major depression compared to controls (36.4 vs. 22.5 per 100,000 person years). Partial mediation by SAF of the association between affective disorders and mortality was shown (9.0-10.5%, P<.001-.002), although attenuated by cardiometabolic parameters and history of physical illness. For major depressive disorder, partial mediation by 5.5-10.3% was shown (crude model: P<.001; fully adjusted model: P=.03).
The relatively short duration of follow-up and the relatively young cohort resulted in a lack of power to detect an association between mortality and dysthymia, social phobia and two or more comorbid disorders.
Evidence of partial mediation by SAF of the association between affective disorders and all-cause and natural-cause mortality was demonstrated, although attenuated by health factors. For major depression, mediation by SAF was largest and remained significant after adjustment for sociodemographic and health factors, identifying oxidative stress as possible determinant of premature death.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33601681</pmid><doi>10.1016/j.jad.2020.12.202</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5085-1108</orcidid><orcidid>https://orcid.org/0000-0003-0361-3139</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycation end products Anxiety disorders Cohort Studies Depressive Disorder, Major - epidemiology Depressive Disorder, Major - mortality Fluorescence Glycation End Products, Advanced Humans Mediation Analysis Mood Disorders Mortality Oxidative stress Skin |
| title | Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis |
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