Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA‐AM in HCN‐2 neuronal cells

Hypaconitine, a neuromuscular blocker, is a diterpene alkaloid found in the root of Aconitum carmichaelii. Although hypaconitine was shown to affect various physiological responses in neurological models, the effect of hypaconitine on cell viability and the mechanism of its action of Ca2+ handling i...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2021-05, Vol.48 (5), p.801-810
Hauptverfasser:	Hsu, Shu‐Shong, Lin, Yung‐Shang, Liang, Wei‐Zhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine - analogs & derivatives Aconitine - pharmacology Alkaloids BAPTA‐AM Ca2+ handling Ca2+-transporting ATPase Calcium (extracellular) Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium channels Calcium Chelating Agents - pharmacology Calcium influx Calcium ions Calcium Signaling - drug effects Calcium signalling Cell death Cell Line Cell lines Cell proliferation Cell Survival - drug effects Cell viability Chelation Cytotoxicity Diterpenes Diterpenes - pharmacology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Endoplasmic reticulum Enzyme inhibitors Fluorescent dyes Fluorescent indicators HCN‐2 cells Humans hypaconitine Kinases Modulators Neuromodulation Neurons - drug effects Neurons - metabolism Phospholipase C Physiological effects Physiological responses Protein kinase C Reagents store‐operated Ca2+ entry Thapsigargin Toxicity
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