Canine interferon lambda 3 expressed using an adenoviral vector effectively induces antiviral activity against canine influenza virus

•This is the first experimental study on the antiviral effects of canine IFN-λ3.•The tetracycline-operator system enabled high production of recombinant adenovirus.•The recombinant adenovirus expressed the canine IFN-λ3 in canine target cells.•Canine IFN-λ3 inhibited canine influenza virus (A/H3N2)...

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Veröffentlicht in:	Virus research 2021-04, Vol.296, p.198342-198342, Article 198342
Hauptverfasser:	Kim, Dong-Hwi, Park, Byung-Joo, Ahn, Hee-Seop, Go, Hyeon-Jeong, Kim, Da-Yoon, Kim, Jae-Hyeong, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Choi, In-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviral vector Animals Antiviral Agents - pharmacology Antiviral therapy Canine influenza virus Canine interferon lambda Dogs Humans Influenza, Human Interferons - genetics Madin Darby Canine Kidney Cells Orthomyxoviridae - genetics Virus Replication
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