Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid

•Kynurenine 3-monooxygenase knock out (KMO KO) mice showed depression-like behaviors.•Kynurenic acid (KA) level was increased in the prefrontal cortex of KMO KO mice.•α7 Nicotinic acetylcholine receptor (α7nAChR) mRNA was increased in the KMO KO mice.•Nicotine attenuated depression-like behaviors in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Behavioural brain research 2021-05, Vol.405, p.113191-113191, Article 113191
Hauptverfasser:	Mori, Yuko, Mouri, Akihiro, Kunisawa, Kazuo, Hirakawa, Mami, Kubota, Hisayoshi, Kosuge, Aika, Niijima, Moe, Hasegawa, Masaya, Kurahashi, Hitomi, Murakami, Reiko, Hoshi, Masato, Nakano, Takashi, Fujigaki, Suwako, Fujigaki, Hidetsugu, Yamamoto, Yasuko, Nabeshima, Toshitaka, Saito, Kuniaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine - analogs & derivatives Aconitine - pharmacology alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Behavior, Animal - drug effects Behavior, Animal - physiology Depression Depression - chemically induced Depression - drug therapy Depression - metabolism Disease Models, Animal Kynurenic acid Kynurenic Acid - metabolism Kynurenine 3-monooxygenase Kynurenine 3-Monooxygenase - deficiency Male Mice Mice, Inbred C57BL Mice, Knockout Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism α7 Nicotinic acetylcholine receptor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!