The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation
Bloodstream infection (BSI) is a major infectious complication after allogeneic hematopoietic cell transplantation (HCT). To clarify the impact of graft cell source on the incidence of BSI after transplantation, we retrospectively examined 782 adult patients receiving their first allogeneic HCT: 122...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2021-07, Vol.56 (7), p.1625-1634 |
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| creator | Takagi, Shinsuke Ogura, Sho Araoka, Hideki Uchida, Naoyuki Mitsuki, Takashi Yuasa, Mitsuhiro Kageyama, Kosei Kaji, Daisuke Taya, Yuki Nishida, Aya Kimura, Muneyoshi Ishiwata, Kazuya Yamamoto, Hisashi Yamamoto, Go Asano-Mori, Yuki Koike, Yukako Izutsu, Koji Wake, Atsushi Makino, Shigeyoshi Yoneyama, Akiko Taniguchi, Shuichi |
| description | Bloodstream infection (BSI) is a major infectious complication after allogeneic hematopoietic cell transplantation (HCT). To clarify the impact of graft cell source on the incidence of BSI after transplantation, we retrospectively examined 782 adult patients receiving their first allogeneic HCT: 122 recipients of related peripheral blood stem cells or bone marrow, 215 recipients of unrelated bone marrow, and 445 recipients of unrelated umbilical cord blood (U-CB). The cumulative incidence of BSI was 42.5% at 100 days after transplantation (95% confidence interval, 39.0–46.0). Gram-positive cocci were present in 64.2% of detected isolates. Among the pre-transplant factors including age, performance status, primary disease, disease status, graft cell source, sex and ABO blood type matching, and the intensity of conditioning regimen, U-CB use was identified as the most significant risk factor for BSI by multivariate analysis (hazard ratio, 1.76; 95% confidence interval, 1.40–2.22;
p
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| doi_str_mv | 10.1038/s41409-021-01229-6 |
| format | Article |
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p
< 0.00001). Among the U-CB recipients, those who are not in remission at the time of transplantation were at the greatest risk of BSI (hazard ratio, 1.69; 95% confidence interval, 1.14–2.50;
p
< 0.01). The study makes it clear that graft cell source has an impact on BSI development after allogeneic HCT.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/s41409-021-01229-6</identifier><identifier>PMID: 33608659</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/255 ; ABO system ; Blood groups ; Bone marrow ; Cell Biology ; Confidence intervals ; Cord blood ; Donation of organs, tissues, etc ; Grafting ; Gram-positive cocci ; Health aspects ; Health hazards ; Hematology ; Hematopoietic stem cells ; Infections ; Internal Medicine ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Peripheral blood ; Public Health ; Remission ; Risk analysis ; Risk factors ; Sepsis ; Statistics ; Stem cell transplantation ; Stem Cells ; Transplantation ; Transplants & implants ; Umbilical cord</subject><ispartof>Bone marrow transplantation (Basingstoke), 2021-07, Vol.56 (7), p.1625-1634</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-895c14166638f153c610f2ebde732577b39e165e1004c9f486664f0e4c57be1e3</citedby><cites>FETCH-LOGICAL-c539t-895c14166638f153c610f2ebde732577b39e165e1004c9f486664f0e4c57be1e3</cites><orcidid>0000-0003-0441-393X ; 0000-0001-5952-5926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33608659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takagi, Shinsuke</creatorcontrib><creatorcontrib>Ogura, Sho</creatorcontrib><creatorcontrib>Araoka, Hideki</creatorcontrib><creatorcontrib>Uchida, Naoyuki</creatorcontrib><creatorcontrib>Mitsuki, Takashi</creatorcontrib><creatorcontrib>Yuasa, Mitsuhiro</creatorcontrib><creatorcontrib>Kageyama, Kosei</creatorcontrib><creatorcontrib>Kaji, Daisuke</creatorcontrib><creatorcontrib>Taya, Yuki</creatorcontrib><creatorcontrib>Nishida, Aya</creatorcontrib><creatorcontrib>Kimura, Muneyoshi</creatorcontrib><creatorcontrib>Ishiwata, Kazuya</creatorcontrib><creatorcontrib>Yamamoto, Hisashi</creatorcontrib><creatorcontrib>Yamamoto, Go</creatorcontrib><creatorcontrib>Asano-Mori, Yuki</creatorcontrib><creatorcontrib>Koike, Yukako</creatorcontrib><creatorcontrib>Izutsu, Koji</creatorcontrib><creatorcontrib>Wake, Atsushi</creatorcontrib><creatorcontrib>Makino, Shigeyoshi</creatorcontrib><creatorcontrib>Yoneyama, Akiko</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><title>The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Bloodstream infection (BSI) is a major infectious complication after allogeneic hematopoietic cell transplantation (HCT). To clarify the impact of graft cell source on the incidence of BSI after transplantation, we retrospectively examined 782 adult patients receiving their first allogeneic HCT: 122 recipients of related peripheral blood stem cells or bone marrow, 215 recipients of unrelated bone marrow, and 445 recipients of unrelated umbilical cord blood (U-CB). The cumulative incidence of BSI was 42.5% at 100 days after transplantation (95% confidence interval, 39.0–46.0). Gram-positive cocci were present in 64.2% of detected isolates. Among the pre-transplant factors including age, performance status, primary disease, disease status, graft cell source, sex and ABO blood type matching, and the intensity of conditioning regimen, U-CB use was identified as the most significant risk factor for BSI by multivariate analysis (hazard ratio, 1.76; 95% confidence interval, 1.40–2.22;
p
< 0.00001). Among the U-CB recipients, those who are not in remission at the time of transplantation were at the greatest risk of BSI (hazard ratio, 1.69; 95% confidence interval, 1.14–2.50;
p
< 0.01). The study makes it clear that graft cell source has an impact on BSI development after allogeneic HCT.</description><subject>692/499</subject><subject>692/699/255</subject><subject>ABO system</subject><subject>Blood groups</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Confidence intervals</subject><subject>Cord blood</subject><subject>Donation of organs, tissues, etc</subject><subject>Grafting</subject><subject>Gram-positive cocci</subject><subject>Health aspects</subject><subject>Health hazards</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Peripheral blood</subject><subject>Public Health</subject><subject>Remission</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sepsis</subject><subject>Statistics</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Umbilical 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impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation</title><author>Takagi, Shinsuke ; Ogura, Sho ; Araoka, Hideki ; Uchida, Naoyuki ; Mitsuki, Takashi ; Yuasa, Mitsuhiro ; Kageyama, Kosei ; Kaji, Daisuke ; Taya, Yuki ; Nishida, Aya ; Kimura, Muneyoshi ; Ishiwata, Kazuya ; Yamamoto, Hisashi ; Yamamoto, Go ; Asano-Mori, Yuki ; Koike, Yukako ; Izutsu, Koji ; Wake, Atsushi ; Makino, Shigeyoshi ; Yoneyama, Akiko ; Taniguchi, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-895c14166638f153c610f2ebde732577b39e165e1004c9f486664f0e4c57be1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/499</topic><topic>692/699/255</topic><topic>ABO system</topic><topic>Blood groups</topic><topic>Bone marrow</topic><topic>Cell Biology</topic><topic>Confidence intervals</topic><topic>Cord blood</topic><topic>Donation of organs, tissues, etc</topic><topic>Grafting</topic><topic>Gram-positive cocci</topic><topic>Health aspects</topic><topic>Health hazards</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Peripheral blood</topic><topic>Public Health</topic><topic>Remission</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sepsis</topic><topic>Statistics</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takagi, Shinsuke</creatorcontrib><creatorcontrib>Ogura, Sho</creatorcontrib><creatorcontrib>Araoka, Hideki</creatorcontrib><creatorcontrib>Uchida, 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Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>56</volume><issue>7</issue><spage>1625</spage><epage>1634</epage><pages>1625-1634</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><abstract>Bloodstream infection (BSI) is a major infectious complication after allogeneic hematopoietic cell transplantation (HCT). To clarify the impact of graft cell source on the incidence of BSI after transplantation, we retrospectively examined 782 adult patients receiving their first allogeneic HCT: 122 recipients of related peripheral blood stem cells or bone marrow, 215 recipients of unrelated bone marrow, and 445 recipients of unrelated umbilical cord blood (U-CB). The cumulative incidence of BSI was 42.5% at 100 days after transplantation (95% confidence interval, 39.0–46.0). Gram-positive cocci were present in 64.2% of detected isolates. Among the pre-transplant factors including age, performance status, primary disease, disease status, graft cell source, sex and ABO blood type matching, and the intensity of conditioning regimen, U-CB use was identified as the most significant risk factor for BSI by multivariate analysis (hazard ratio, 1.76; 95% confidence interval, 1.40–2.22;
p
< 0.00001). Among the U-CB recipients, those who are not in remission at the time of transplantation were at the greatest risk of BSI (hazard ratio, 1.69; 95% confidence interval, 1.14–2.50;
p
< 0.01). The study makes it clear that graft cell source has an impact on BSI development after allogeneic HCT.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33608659</pmid><doi>10.1038/s41409-021-01229-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0441-393X</orcidid><orcidid>https://orcid.org/0000-0001-5952-5926</orcidid></addata></record> |
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| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2021-07, Vol.56 (7), p.1625-1634 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_2491943315 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 692/499 692/699/255 ABO system Blood groups Bone marrow Cell Biology Confidence intervals Cord blood Donation of organs, tissues, etc Grafting Gram-positive cocci Health aspects Health hazards Hematology Hematopoietic stem cells Infections Internal Medicine Medicine Medicine & Public Health Multivariate analysis Peripheral blood Public Health Remission Risk analysis Risk factors Sepsis Statistics Stem cell transplantation Stem Cells Transplantation Transplants & implants Umbilical cord |
| title | The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantation |
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