McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis

The aim of the present study was to investigate the anti-inflammatory response mediated of the M1 muscarinic acetylcholine receptor (mAChR) during experimental colitis. After the induction of 6% acetic acid colitis, mice were treated with McN-A-343 0.5, 1.0, and 1.5 mg/kg or dexamethasone (DEXA, 2.0...

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Veröffentlicht in:	Life sciences (1973) 2021-05, Vol.272, p.119194-119194, Article 119194
Hauptverfasser:	Magalhães, Diva de Aguiar, Batista, Jalles Arruda, Sousa, Stefany Guimarães, Ferreira, Jayro dos Santos, da Rocha Rodrigues, Lauanda, Pereira, Cynthia Maria Carvalho, do Nascimento Lima, José Victor, de Albuquerque, Ieda Figueira, Bezerra, Nayonara Lanara Sousa Dutra, Monteiro, Carlos Eduardo da Silva, Franco, Alvaro Xavier, da Costa Filho, Humberto Barbosa, Ferreira, Francisco Cleber Silva, Havt, Alexandre, Di Lenardo, David, Vasconcelos, Daniel Fernando Pereira, de Oliveira, Jefferson Soares, Soares, Pedro Marcos Gomes, Barbosa, André Luiz dos Reis
Format:	Artikel
Sprache:	eng
Schlagworte:	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride - metabolism (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride - pharmacology Acetic acid Acetylcholine receptors (muscarinic) Agonists Animals Colitis - drug therapy Colitis - metabolism Colitis, Ulcerative - drug therapy Colitis, Ulcerative - metabolism Colon - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytokines - metabolism Dexamethasone Dexamethasone - pharmacology Disease Models, Animal Dual energy X-ray absorptiometry Gene expression Glutathione Glutathione - metabolism Inflammation Inflammation - pathology Inflammation Mediators - metabolism Inflammatory bowel disease Inflammatory bowel diseases Inflammatory response Interleukin 1 Interleukin-1beta - metabolism Intestine Male Malondialdehyde Malondialdehyde - metabolism Mice Muscarinic Agonists - pharmacology NF-kappa B - metabolism NF-κB protein Nitrogen dioxide Oxidative stress Oxidative Stress - drug effects Peroxidase Pirenzepine Receptor, Muscarinic M1 Stress concentration Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Ulcerative colitis Weight
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