Identification of a new orthonairovirus associated with human febrile illness in China
The genus Orthonairovirus , which is part of the family Nairoviridae , includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals 1 , 2 . In this study,...
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| Veröffentlicht in: | Nature medicine 2021-03, Vol.27 (3), p.434-439 |
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| creator | Ma, Jun Lv, Xiao-Long Zhang, Xu Han, Shu-Zheng Wang, Ze-Dong Li, Liang Sun, He-Ting Ma, Li-Xin Cheng, Zheng-Lei Shao, Jian-Wei Chen, Chen Zhao, Ying-Hua Sui, Liyan Liu, Lin-Na Qian, Jun Wang, Wei Liu, Quan |
| description | The genus
Orthonairovirus
, which is part of the family
Nairoviridae
, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals
1
,
2
. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in
Tamdy orthonairovirus
of the
Nairoviridae
family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. Taken together, these results suggest that this newly discovered orthonairovirus is associated with human febrile illness in China.
Songling virus is a newly discovered orthonairovirus found in the blood of patients hospitalized with febrile illness and having a history of tick bites. |
| doi_str_mv | 10.1038/s41591-020-01228-y |
| format | Article |
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Orthonairovirus
, which is part of the family
Nairoviridae
, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals
1
,
2
. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in
Tamdy orthonairovirus
of the
Nairoviridae
family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. Taken together, these results suggest that this newly discovered orthonairovirus is associated with human febrile illness in China.
Songling virus is a newly discovered orthonairovirus found in the blood of patients hospitalized with febrile illness and having a history of tick bites.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/s41591-020-01228-y</identifier><identifier>PMID: 33603240</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/326/596/2562 ; 692/699/255/2514 ; Adult ; Aged ; Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; China ; Crimean hemorrhagic fever ; Female ; Fever ; Fever - complications ; Fever - virology ; Hemorrhage ; Hepatoma ; Humans ; Illnesses ; Infectious Diseases ; Insect bites ; Letter ; Male ; Metabolic Diseases ; Middle Aged ; Molecular Medicine ; Nairobi sheep disease ; Nairovirus - isolation & purification ; Nairovirus - pathogenicity ; Neurosciences ; Phylogeny ; Tick-Borne Diseases - complications ; Tick-Borne Diseases - virology ; Ticks ; Virus Diseases - complications ; Virus Diseases - virology ; Viruses</subject><ispartof>Nature medicine, 2021-03, Vol.27 (3), p.434-439</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021. corrected publication 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021. corrected publication 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-d002dc5b0014a3101602d9a904c8349aa57329c9edd199588eee937d9e366b9a3</citedby><cites>FETCH-LOGICAL-c419t-d002dc5b0014a3101602d9a904c8349aa57329c9edd199588eee937d9e366b9a3</cites><orcidid>0000-0003-1221-6004 ; 0000-0001-9965-8969 ; 0000-0003-3411-3196</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41591-020-01228-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41591-020-01228-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33603240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Jun</creatorcontrib><creatorcontrib>Lv, Xiao-Long</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Han, Shu-Zheng</creatorcontrib><creatorcontrib>Wang, Ze-Dong</creatorcontrib><creatorcontrib>Li, Liang</creatorcontrib><creatorcontrib>Sun, He-Ting</creatorcontrib><creatorcontrib>Ma, Li-Xin</creatorcontrib><creatorcontrib>Cheng, Zheng-Lei</creatorcontrib><creatorcontrib>Shao, Jian-Wei</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Zhao, Ying-Hua</creatorcontrib><creatorcontrib>Sui, Liyan</creatorcontrib><creatorcontrib>Liu, Lin-Na</creatorcontrib><creatorcontrib>Qian, Jun</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Liu, Quan</creatorcontrib><title>Identification of a new orthonairovirus associated with human febrile illness in China</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>The genus
Orthonairovirus
, which is part of the family
Nairoviridae
, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals
1
,
2
. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in
Tamdy orthonairovirus
of the
Nairoviridae
family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. Taken together, these results suggest that this newly discovered orthonairovirus is associated with human febrile illness in China.
Songling virus is a newly discovered orthonairovirus found in the blood of patients hospitalized with febrile illness and having a history of tick bites.</description><subject>631/326/596/2562</subject><subject>692/699/255/2514</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>China</subject><subject>Crimean hemorrhagic fever</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - complications</subject><subject>Fever - virology</subject><subject>Hemorrhage</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infectious Diseases</subject><subject>Insect bites</subject><subject>Letter</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Nairobi sheep disease</subject><subject>Nairovirus - isolation & purification</subject><subject>Nairovirus - pathogenicity</subject><subject>Neurosciences</subject><subject>Phylogeny</subject><subject>Tick-Borne Diseases - complications</subject><subject>Tick-Borne Diseases - virology</subject><subject>Ticks</subject><subject>Virus Diseases - complications</subject><subject>Virus Diseases - virology</subject><subject>Viruses</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kM1qGzEURkVJqBO3L9BFEWTTzTRXvx4ti0magKGbJGQn5Jk7tcxYcqWZGL99lNhtIYusJKHzffdyCPnC4DsDUV9myZRhFXCogHFeV_sP5IwpqSs2g8eTcodZXdVG6Qk5z3kNAAKU-UgmQmgQXMIZebhtMQy-840bfAw0dtTRgDsa07CKwfkUn3waM3U5x8a7AVu688OKrsaNC7TDZfI9Ut_3AXOmPtD5ygf3iZx2rs_4-XhOyf311d38plr8-nk7_7GoGsnMULUAvG3UEoBJJxgwXd7GGZBNLaRxTs0EN43BtmXGqLpGRCNmrUGh9dI4MSXfDr3bFP-MmAe78bnBvncB45gtl4YZCVqwgl68QddxTKFsZ7kCJpTWmheKH6gmxZwTdnab_MalvWVgX6zbg3VbrNtX63ZfQl-P1eNyg-2_yF_NBRAHIJev8BvT_9nv1D4DnO2NBg</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Ma, Jun</creator><creator>Lv, Xiao-Long</creator><creator>Zhang, Xu</creator><creator>Han, Shu-Zheng</creator><creator>Wang, Ze-Dong</creator><creator>Li, Liang</creator><creator>Sun, He-Ting</creator><creator>Ma, Li-Xin</creator><creator>Cheng, Zheng-Lei</creator><creator>Shao, Jian-Wei</creator><creator>Chen, Chen</creator><creator>Zhao, Ying-Hua</creator><creator>Sui, Liyan</creator><creator>Liu, Lin-Na</creator><creator>Qian, Jun</creator><creator>Wang, Wei</creator><creator>Liu, Quan</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1221-6004</orcidid><orcidid>https://orcid.org/0000-0001-9965-8969</orcidid><orcidid>https://orcid.org/0000-0003-3411-3196</orcidid></search><sort><creationdate>20210301</creationdate><title>Identification of a new orthonairovirus associated with human febrile illness in China</title><author>Ma, Jun ; Lv, Xiao-Long ; Zhang, Xu ; Han, Shu-Zheng ; Wang, Ze-Dong ; Li, Liang ; Sun, He-Ting ; Ma, Li-Xin ; Cheng, Zheng-Lei ; Shao, Jian-Wei ; Chen, Chen ; Zhao, Ying-Hua ; Sui, Liyan ; Liu, Lin-Na ; Qian, Jun ; Wang, Wei ; Liu, Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-d002dc5b0014a3101602d9a904c8349aa57329c9edd199588eee937d9e366b9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/326/596/2562</topic><topic>692/699/255/2514</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>China</topic><topic>Crimean hemorrhagic fever</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - 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Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Jun</au><au>Lv, Xiao-Long</au><au>Zhang, Xu</au><au>Han, Shu-Zheng</au><au>Wang, Ze-Dong</au><au>Li, Liang</au><au>Sun, He-Ting</au><au>Ma, Li-Xin</au><au>Cheng, Zheng-Lei</au><au>Shao, Jian-Wei</au><au>Chen, Chen</au><au>Zhao, Ying-Hua</au><au>Sui, Liyan</au><au>Liu, Lin-Na</au><au>Qian, Jun</au><au>Wang, Wei</au><au>Liu, Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a new orthonairovirus associated with human febrile illness in China</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>27</volume><issue>3</issue><spage>434</spage><epage>439</epage><pages>434-439</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>The genus
Orthonairovirus
, which is part of the family
Nairoviridae
, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals
1
,
2
. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in
Tamdy orthonairovirus
of the
Nairoviridae
family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. Taken together, these results suggest that this newly discovered orthonairovirus is associated with human febrile illness in China.
Songling virus is a newly discovered orthonairovirus found in the blood of patients hospitalized with febrile illness and having a history of tick bites.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33603240</pmid><doi>10.1038/s41591-020-01228-y</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1221-6004</orcidid><orcidid>https://orcid.org/0000-0001-9965-8969</orcidid><orcidid>https://orcid.org/0000-0003-3411-3196</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature medicine, 2021-03, Vol.27 (3), p.434-439 |
| issn | 1078-8956 1546-170X |
| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/326/596/2562 692/699/255/2514 Adult Aged Antibodies Biomedical and Life Sciences Biomedicine Cancer Research China Crimean hemorrhagic fever Female Fever Fever - complications Fever - virology Hemorrhage Hepatoma Humans Illnesses Infectious Diseases Insect bites Letter Male Metabolic Diseases Middle Aged Molecular Medicine Nairobi sheep disease Nairovirus - isolation & purification Nairovirus - pathogenicity Neurosciences Phylogeny Tick-Borne Diseases - complications Tick-Borne Diseases - virology Ticks Virus Diseases - complications Virus Diseases - virology Viruses |
| title | Identification of a new orthonairovirus associated with human febrile illness in China |
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