White matter aging drives microglial diversity

Aging results in gray and white matter degeneration, but the specific microglial responses are unknown. Using single-cell RNA sequencing from white and gray matter separately, we identified white matter-associated microglia (WAMs), which share parts of the disease-associated microglia (DAM) gene sig...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2021-04, Vol.109 (7), p.1100-1117.e10
Hauptverfasser:	Safaiyan, Shima, Besson-Girard, Simon, Kaya, Tuğberk, Cantuti-Castelvetri, Ludovico, Liu, Lu, Ji, Hao, Schifferer, Martina, Gouna, Garyfallia, Usifo, Fumere, Kannaiyan, Nirmal, Fitzner, Dirk, Xiang, Xianyuan, Rossner, Moritz J., Brendel, Matthias, Gokce, Ozgun, Simons, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - physiology Alzheimer Disease - genetics Alzheimer's disease Animal models Animals ApoE Apolipoprotein E Apolipoproteins E - genetics Datasets Demyelinating Diseases - pathology Gene expression Gene Expression Regulation Genomics Gray Matter - cytology Gray Matter - growth & development Immunohistochemistry Lipid metabolism Lipids Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Metabolism Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - physiology Microglia - ultrastructure microglia, aging Myelin Myelin Sheath - metabolism Myeloid cells Neurodegeneration Neurodegenerative diseases Pathology Phagocytes Receptors, Immunologic - biosynthesis Receptors, Immunologic - genetics Sequence Analysis, RNA Signal Transduction - physiology Single-Cell Analysis Substantia alba Substantia grisea Transcription activation Trem2 white matter White Matter - cytology White Matter - growth & development
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