Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials
Objective The aim of this meta-analysis was to evaluate the effectiveness of glutamine for preventing or treating moderate-to-severe oral mucositis induced by chemotherapy or radiation therapy in patients with cancer. Methods PubMed, Cochrane Library, and Embase were searched for eligible randomized...
Gespeichert in:
| Veröffentlicht in: | Supportive care in cancer 2021-08, Vol.29 (8), p.4885-4892 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4892 |
|---|---|
| container_issue | 8 |
| container_start_page | 4885 |
| container_title | Supportive care in cancer |
| container_volume | 29 |
| creator | Peng, Tzu-Rong Lin, Hung-Hong Yang, Li-Jou Wu, Ta-Wei |
| description | Objective
The aim of this meta-analysis was to evaluate the effectiveness of glutamine for preventing or treating moderate-to-severe oral mucositis induced by chemotherapy or radiation therapy in patients with cancer.
Methods
PubMed, Cochrane Library, and Embase were searched for eligible randomized controlled trials (RCTs) up to June 2020. The outcomes analyzed were oral mucositis (at all levels of severity). Data were pooled using the random-effects model and are expressed as risk ratios (RRs) and corresponding 95% confidence intervals (CIs). Heterogeneity was assessed and quantified using
I
2
.
Results
Sixteen RCTs were included in this review. In this meta-analysis, compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy (RR, 0.53; 95% CI, 0.32–0.88). In subgroup analysis, oral glutamine administration (RR, 0.56; 95% CI, 0.34–0.92) and a medium or low daily dose of glutamine (RR, 0.58; 95% CI, 0.44–0.77; RR, 0.53; 95% CI, 0.28–0.94; respectively) decreased risk. Glutamine caused a borderline significant reduction in the risk of grade 3 and 4 oral mucositis induced by radiotherapy (RR, 0.75; 95% CI, 0.58–0.99) and especially in its prevention (RR, 0.51; 95% CI, 0.28–0.94).
Conclusions
Glutamine significantly reduces the risk of oral mucositis during chemotherapy or radiation therapy. Furthermore, large prospective trials are required to support these findings. |
| doi_str_mv | 10.1007/s00520-021-06060-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2491065430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A666681926</galeid><sourcerecordid>A666681926</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-ac57ba3283965815681c5e6293c96e28a27c4b8ece1edb89d556697491bce23d3</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MbN1HzPxF0p9QMKbnQdMpkz15RJck0yQl36y830Vosi5iwScp73JScvQs8pOaOE9K8LIZKRjjDaEdWq0w_QjgrOu55z_RDtiBa0E1zKE_SklGtCaN9L9hidcC710HOxQz8u5xlc9d8gQik4zXi_rNUGHwH7iOsXwMFGu4cAsW7tlO2Cw-pS8dWXjXE2Osj4YKtvTHmDLQ5Qbddky03xt6bZxikF_x0m7FKsOS1LO9bs7VKeokdz2-DZ3X6KPr-9_HTxvrv6-O7DxflV54RgtbNO9qPlbOBayYFKNVAnQTHNnVbABst6J8YBHFCYxkFPUiqle6Hp6IDxiZ-iV0ffQ05fVyjVBF8cLIuNkNZiWEOJkoKThr78C71Oa27zNEqKhgyNvKf2dgHj45xqtm4zNeeqrYFqtlFn_6BaTRB8-wyYfbv_Q8COApdTKRlmc8g-2HxjKDFb8OYYvGnBm9vgjW6iF3cvXscA02_Jr6QbwI9Aaa24h3w_0n9sfwJTpbgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545438106</pqid></control><display><type>article</type><title>Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials</title><source>Springer Nature - Complete Springer Journals</source><creator>Peng, Tzu-Rong ; Lin, Hung-Hong ; Yang, Li-Jou ; Wu, Ta-Wei</creator><creatorcontrib>Peng, Tzu-Rong ; Lin, Hung-Hong ; Yang, Li-Jou ; Wu, Ta-Wei</creatorcontrib><description>Objective
The aim of this meta-analysis was to evaluate the effectiveness of glutamine for preventing or treating moderate-to-severe oral mucositis induced by chemotherapy or radiation therapy in patients with cancer.
Methods
PubMed, Cochrane Library, and Embase were searched for eligible randomized controlled trials (RCTs) up to June 2020. The outcomes analyzed were oral mucositis (at all levels of severity). Data were pooled using the random-effects model and are expressed as risk ratios (RRs) and corresponding 95% confidence intervals (CIs). Heterogeneity was assessed and quantified using
I
2
.
Results
Sixteen RCTs were included in this review. In this meta-analysis, compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy (RR, 0.53; 95% CI, 0.32–0.88). In subgroup analysis, oral glutamine administration (RR, 0.56; 95% CI, 0.34–0.92) and a medium or low daily dose of glutamine (RR, 0.58; 95% CI, 0.44–0.77; RR, 0.53; 95% CI, 0.28–0.94; respectively) decreased risk. Glutamine caused a borderline significant reduction in the risk of grade 3 and 4 oral mucositis induced by radiotherapy (RR, 0.75; 95% CI, 0.58–0.99) and especially in its prevention (RR, 0.51; 95% CI, 0.28–0.94).
Conclusions
Glutamine significantly reduces the risk of oral mucositis during chemotherapy or radiation therapy. Furthermore, large prospective trials are required to support these findings.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-021-06060-9</identifier><identifier>PMID: 33598734</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Cancer patients ; Care and treatment ; Chemotherapy ; Clinical trials ; Comparative analysis ; Glutamine ; Medicine ; Medicine & Public Health ; Meta-analysis ; Mucositis ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Radiation ; Radiation therapy ; Radiotherapy ; Rehabilitation Medicine ; Stomatitis</subject><ispartof>Supportive care in cancer, 2021-08, Vol.29 (8), p.4885-4892</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021. corrected publication 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021. corrected publication 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ac57ba3283965815681c5e6293c96e28a27c4b8ece1edb89d556697491bce23d3</citedby><cites>FETCH-LOGICAL-c442t-ac57ba3283965815681c5e6293c96e28a27c4b8ece1edb89d556697491bce23d3</cites><orcidid>0000-0002-0754-5682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-021-06060-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-021-06060-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33598734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Tzu-Rong</creatorcontrib><creatorcontrib>Lin, Hung-Hong</creatorcontrib><creatorcontrib>Yang, Li-Jou</creatorcontrib><creatorcontrib>Wu, Ta-Wei</creatorcontrib><title>Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Objective
The aim of this meta-analysis was to evaluate the effectiveness of glutamine for preventing or treating moderate-to-severe oral mucositis induced by chemotherapy or radiation therapy in patients with cancer.
Methods
PubMed, Cochrane Library, and Embase were searched for eligible randomized controlled trials (RCTs) up to June 2020. The outcomes analyzed were oral mucositis (at all levels of severity). Data were pooled using the random-effects model and are expressed as risk ratios (RRs) and corresponding 95% confidence intervals (CIs). Heterogeneity was assessed and quantified using
I
2
.
Results
Sixteen RCTs were included in this review. In this meta-analysis, compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy (RR, 0.53; 95% CI, 0.32–0.88). In subgroup analysis, oral glutamine administration (RR, 0.56; 95% CI, 0.34–0.92) and a medium or low daily dose of glutamine (RR, 0.58; 95% CI, 0.44–0.77; RR, 0.53; 95% CI, 0.28–0.94; respectively) decreased risk. Glutamine caused a borderline significant reduction in the risk of grade 3 and 4 oral mucositis induced by radiotherapy (RR, 0.75; 95% CI, 0.58–0.99) and especially in its prevention (RR, 0.51; 95% CI, 0.28–0.94).
Conclusions
Glutamine significantly reduces the risk of oral mucositis during chemotherapy or radiation therapy. Furthermore, large prospective trials are required to support these findings.</description><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Comparative analysis</subject><subject>Glutamine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Mucositis</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Rehabilitation Medicine</subject><subject>Stomatitis</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MbN1HzPxF0p9QMKbnQdMpkz15RJck0yQl36y830Vosi5iwScp73JScvQs8pOaOE9K8LIZKRjjDaEdWq0w_QjgrOu55z_RDtiBa0E1zKE_SklGtCaN9L9hidcC710HOxQz8u5xlc9d8gQik4zXi_rNUGHwH7iOsXwMFGu4cAsW7tlO2Cw-pS8dWXjXE2Osj4YKtvTHmDLQ5Qbddky03xt6bZxikF_x0m7FKsOS1LO9bs7VKeokdz2-DZ3X6KPr-9_HTxvrv6-O7DxflV54RgtbNO9qPlbOBayYFKNVAnQTHNnVbABst6J8YBHFCYxkFPUiqle6Hp6IDxiZ-iV0ffQ05fVyjVBF8cLIuNkNZiWEOJkoKThr78C71Oa27zNEqKhgyNvKf2dgHj45xqtm4zNeeqrYFqtlFn_6BaTRB8-wyYfbv_Q8COApdTKRlmc8g-2HxjKDFb8OYYvGnBm9vgjW6iF3cvXscA02_Jr6QbwI9Aaa24h3w_0n9sfwJTpbgw</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Peng, Tzu-Rong</creator><creator>Lin, Hung-Hong</creator><creator>Yang, Li-Jou</creator><creator>Wu, Ta-Wei</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0754-5682</orcidid></search><sort><creationdate>20210801</creationdate><title>Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials</title><author>Peng, Tzu-Rong ; Lin, Hung-Hong ; Yang, Li-Jou ; Wu, Ta-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ac57ba3283965815681c5e6293c96e28a27c4b8ece1edb89d556697491bce23d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Comparative analysis</topic><topic>Glutamine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Mucositis</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Radiotherapy</topic><topic>Rehabilitation Medicine</topic><topic>Stomatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Tzu-Rong</creatorcontrib><creatorcontrib>Lin, Hung-Hong</creatorcontrib><creatorcontrib>Yang, Li-Jou</creatorcontrib><creatorcontrib>Wu, Ta-Wei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Tzu-Rong</au><au>Lin, Hung-Hong</au><au>Yang, Li-Jou</au><au>Wu, Ta-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>29</volume><issue>8</issue><spage>4885</spage><epage>4892</epage><pages>4885-4892</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Objective
The aim of this meta-analysis was to evaluate the effectiveness of glutamine for preventing or treating moderate-to-severe oral mucositis induced by chemotherapy or radiation therapy in patients with cancer.
Methods
PubMed, Cochrane Library, and Embase were searched for eligible randomized controlled trials (RCTs) up to June 2020. The outcomes analyzed were oral mucositis (at all levels of severity). Data were pooled using the random-effects model and are expressed as risk ratios (RRs) and corresponding 95% confidence intervals (CIs). Heterogeneity was assessed and quantified using
I
2
.
Results
Sixteen RCTs were included in this review. In this meta-analysis, compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy (RR, 0.53; 95% CI, 0.32–0.88). In subgroup analysis, oral glutamine administration (RR, 0.56; 95% CI, 0.34–0.92) and a medium or low daily dose of glutamine (RR, 0.58; 95% CI, 0.44–0.77; RR, 0.53; 95% CI, 0.28–0.94; respectively) decreased risk. Glutamine caused a borderline significant reduction in the risk of grade 3 and 4 oral mucositis induced by radiotherapy (RR, 0.75; 95% CI, 0.58–0.99) and especially in its prevention (RR, 0.51; 95% CI, 0.28–0.94).
Conclusions
Glutamine significantly reduces the risk of oral mucositis during chemotherapy or radiation therapy. Furthermore, large prospective trials are required to support these findings.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33598734</pmid><doi>10.1007/s00520-021-06060-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0754-5682</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2021-08, Vol.29 (8), p.4885-4892 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2491065430 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer Cancer patients Care and treatment Chemotherapy Clinical trials Comparative analysis Glutamine Medicine Medicine & Public Health Meta-analysis Mucositis Nursing Nursing Research Oncology Original Article Pain Medicine Radiation Radiation therapy Radiotherapy Rehabilitation Medicine Stomatitis |
| title | Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A07%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effectiveness%20of%20glutamine%20in%20the%20management%20of%20oral%20mucositis%20in%20cancer%20patients:%20a%20meta-analysis%20of%20randomized%20controlled%20trials&rft.jtitle=Supportive%20care%20in%20cancer&rft.au=Peng,%20Tzu-Rong&rft.date=2021-08-01&rft.volume=29&rft.issue=8&rft.spage=4885&rft.epage=4892&rft.pages=4885-4892&rft.issn=0941-4355&rft.eissn=1433-7339&rft_id=info:doi/10.1007/s00520-021-06060-9&rft_dat=%3Cgale_proqu%3EA666681926%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2545438106&rft_id=info:pmid/33598734&rft_galeid=A666681926&rfr_iscdi=true |