The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis
Purpose There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC. Methods A systematic search for articles in databases (Pu...
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| Veröffentlicht in: | International journal of colorectal disease 2021-07, Vol.36 (7), p.1329-1344 |
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| container_title | International journal of colorectal disease |
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| creator | Xu, Yunbao Qian, Mingxia Hong, Jiaze Ng, Derry Minyao Yang, Tong Xu, Liuhong Ye, Xia |
| description | Purpose
There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.
Methods
A systematic search for articles in databases (Pubmed, Web of Science, EBSCO and Cochrane Library) was terminated in April 2020. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.
Results
According to the estimated pooled OR from 21 eligible studies, covering 904,152 people, the use of vitamin D was inversely associated with the incidence of CRC [OR = 0.87, (0.82–0.92)]. Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients [HR = 0.91, (0.83–0.98)].
Conclusion
This meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena. |
| doi_str_mv | 10.1007/s00384-021-03879-w |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2491065404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714487104</galeid><sourcerecordid>A714487104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-74c15e56fb05dcc073659d39fc552ee04b294e66d46ffcc181d0b88453ca58d33</originalsourceid><addsrcrecordid>eNp9kcFvFCEUxonR2G31H_BgSLx4mQoDzDDemmrVpImXeibsm0elmYEVmN3sfy_drTYaYzjAe-_3fXnkI-QVZ-ecsf5dZkxo2bCWN_XRD83uCVlxKdqGt137lKwYr00-KH1CTnO-Y7XuevmcnAihBt0rviLLzXek6BxCodHRrS929oF-oDHQUkcRYEkJAyC1YaQjbnGKmxnDAYc4xVSldqJgK5PeU0vzPhecbfFAE2497g7KGYttbLDTPvv8gjxzdsr48uE-I9-uPt5cfm6uv376cnlx3YCUbWl6CVyh6tyaqRGA9aJTwygGB0q1iEyu20Fi142ycw6Aaz6ytdZSCbBKj0KckbdH302KPxbMxcw-A06TDRiXbFo5cNYpyWRF3_yF3sUl1X0rVQHOlebikbq1ExofXCzJwr2puei5lLrnB6_zf1D1jDh7iAGdr_0_BO1RACnmnNCZTfKzTXvDmbnP2hyzNjVrc8ja7Kro9cPGy3rG8bfkV7gVEEcg11G4xfT4pf_Y_gTOrbOK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2540115813</pqid></control><display><type>article</type><title>The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis</title><source>SpringerLink Journals - AutoHoldings</source><creator>Xu, Yunbao ; Qian, Mingxia ; Hong, Jiaze ; Ng, Derry Minyao ; Yang, Tong ; Xu, Liuhong ; Ye, Xia</creator><creatorcontrib>Xu, Yunbao ; Qian, Mingxia ; Hong, Jiaze ; Ng, Derry Minyao ; Yang, Tong ; Xu, Liuhong ; Ye, Xia</creatorcontrib><description>Purpose
There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.
Methods
A systematic search for articles in databases (Pubmed, Web of Science, EBSCO and Cochrane Library) was terminated in April 2020. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.
Results
According to the estimated pooled OR from 21 eligible studies, covering 904,152 people, the use of vitamin D was inversely associated with the incidence of CRC [OR = 0.87, (0.82–0.92)]. Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients [HR = 0.91, (0.83–0.98)].
Conclusion
This meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-021-03879-w</identifier><identifier>PMID: 33598751</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alfacalcidol ; Analysis ; Calcifediol ; Colorectal cancer ; Colorectal carcinoma ; Gastroenterology ; Hepatology ; Internal Medicine ; Medical prognosis ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Meta-analysis ; Proctology ; Prognosis ; Review ; Surgery ; Survival ; Vitamin D</subject><ispartof>International journal of colorectal disease, 2021-07, Vol.36 (7), p.1329-1344</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-74c15e56fb05dcc073659d39fc552ee04b294e66d46ffcc181d0b88453ca58d33</citedby><cites>FETCH-LOGICAL-c442t-74c15e56fb05dcc073659d39fc552ee04b294e66d46ffcc181d0b88453ca58d33</cites><orcidid>0000-0002-6720-5647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-021-03879-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-021-03879-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33598751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Yunbao</creatorcontrib><creatorcontrib>Qian, Mingxia</creatorcontrib><creatorcontrib>Hong, Jiaze</creatorcontrib><creatorcontrib>Ng, Derry Minyao</creatorcontrib><creatorcontrib>Yang, Tong</creatorcontrib><creatorcontrib>Xu, Liuhong</creatorcontrib><creatorcontrib>Ye, Xia</creatorcontrib><title>The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose
There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.
Methods
A systematic search for articles in databases (Pubmed, Web of Science, EBSCO and Cochrane Library) was terminated in April 2020. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.
Results
According to the estimated pooled OR from 21 eligible studies, covering 904,152 people, the use of vitamin D was inversely associated with the incidence of CRC [OR = 0.87, (0.82–0.92)]. Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients [HR = 0.91, (0.83–0.98)].
Conclusion
This meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena.</description><subject>Alfacalcidol</subject><subject>Analysis</subject><subject>Calcifediol</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Internal Medicine</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Proctology</subject><subject>Prognosis</subject><subject>Review</subject><subject>Surgery</subject><subject>Survival</subject><subject>Vitamin D</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcFvFCEUxonR2G31H_BgSLx4mQoDzDDemmrVpImXeibsm0elmYEVmN3sfy_drTYaYzjAe-_3fXnkI-QVZ-ecsf5dZkxo2bCWN_XRD83uCVlxKdqGt137lKwYr00-KH1CTnO-Y7XuevmcnAihBt0rviLLzXek6BxCodHRrS929oF-oDHQUkcRYEkJAyC1YaQjbnGKmxnDAYc4xVSldqJgK5PeU0vzPhecbfFAE2497g7KGYttbLDTPvv8gjxzdsr48uE-I9-uPt5cfm6uv376cnlx3YCUbWl6CVyh6tyaqRGA9aJTwygGB0q1iEyu20Fi142ycw6Aaz6ytdZSCbBKj0KckbdH302KPxbMxcw-A06TDRiXbFo5cNYpyWRF3_yF3sUl1X0rVQHOlebikbq1ExofXCzJwr2puei5lLrnB6_zf1D1jDh7iAGdr_0_BO1RACnmnNCZTfKzTXvDmbnP2hyzNjVrc8ja7Kro9cPGy3rG8bfkV7gVEEcg11G4xfT4pf_Y_gTOrbOK</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Xu, Yunbao</creator><creator>Qian, Mingxia</creator><creator>Hong, Jiaze</creator><creator>Ng, Derry Minyao</creator><creator>Yang, Tong</creator><creator>Xu, Liuhong</creator><creator>Ye, Xia</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6720-5647</orcidid></search><sort><creationdate>20210701</creationdate><title>The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis</title><author>Xu, Yunbao ; Qian, Mingxia ; Hong, Jiaze ; Ng, Derry Minyao ; Yang, Tong ; Xu, Liuhong ; Ye, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-74c15e56fb05dcc073659d39fc552ee04b294e66d46ffcc181d0b88453ca58d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alfacalcidol</topic><topic>Analysis</topic><topic>Calcifediol</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Internal Medicine</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Meta-analysis</topic><topic>Proctology</topic><topic>Prognosis</topic><topic>Review</topic><topic>Surgery</topic><topic>Survival</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Yunbao</creatorcontrib><creatorcontrib>Qian, Mingxia</creatorcontrib><creatorcontrib>Hong, Jiaze</creatorcontrib><creatorcontrib>Ng, Derry Minyao</creatorcontrib><creatorcontrib>Yang, Tong</creatorcontrib><creatorcontrib>Xu, Liuhong</creatorcontrib><creatorcontrib>Ye, Xia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Yunbao</au><au>Qian, Mingxia</au><au>Hong, Jiaze</au><au>Ng, Derry Minyao</au><au>Yang, Tong</au><au>Xu, Liuhong</au><au>Ye, Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>36</volume><issue>7</issue><spage>1329</spage><epage>1344</epage><pages>1329-1344</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Purpose
There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.
Methods
A systematic search for articles in databases (Pubmed, Web of Science, EBSCO and Cochrane Library) was terminated in April 2020. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.
Results
According to the estimated pooled OR from 21 eligible studies, covering 904,152 people, the use of vitamin D was inversely associated with the incidence of CRC [OR = 0.87, (0.82–0.92)]. Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients [HR = 0.91, (0.83–0.98)].
Conclusion
This meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33598751</pmid><doi>10.1007/s00384-021-03879-w</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-6720-5647</orcidid></addata></record> |
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| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2021-07, Vol.36 (7), p.1329-1344 |
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| language | eng |
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| subjects | Alfacalcidol Analysis Calcifediol Colorectal cancer Colorectal carcinoma Gastroenterology Hepatology Internal Medicine Medical prognosis Medical research Medicine Medicine & Public Health Medicine, Experimental Meta-analysis Proctology Prognosis Review Surgery Survival Vitamin D |
| title | The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis |
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