Design, synthesis, and biological evaluation of 3′,4′,5′‐trimethoxy evodiamine derivatives as potential antitumor agents

A series of compounds bearing 3′,4′,5′‐trimethoxy module into the core structure of evodiamine were designed and synthesized. The synthesized compounds were screened in vitro for their antitumor potential. MTT results showed that compounds 14a–14c and 14i–14j had significant effects, with compound 1...

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Veröffentlicht in:	Drug development research 2021-11, Vol.82 (7), p.1021-1032
Hauptverfasser:	Peng, Yijiao, Xiong, Runde, Li, Zhen, Peng, Junmei, Xie, Zhi‐Zhong, Lei, Xiao‐Yong, He, Dongxiu, Tang, Guotao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor agents Cell migration Cell proliferation Cytotoxicity evodiamine Gastric cancer Glycolysis microtubule assembly Synthesis Toxicity trimethoxy benzene Tumor cells Vascular endothelial growth factor
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