Green tea and green tea extract in oncological treatment: A systematic review
: Teas are an essential part of traditional phytotherapy. The aim of this systematic review is to assess the clinical evidence using green tea catechins in cancer care. : A systematic search was conducted searching five electronic databases concerning the effectiveness and risks of epigallocatechin...
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| Veröffentlicht in: | International journal for vitamin and nutrition research 2023-02, Vol.93 (1), p.72-84 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | Wiese, Fanny Kutschan, Sabine Doerfler, Jennifer Mathies, Viktoria Buentzel, Jens Buentzel, Judith Huebner, Jutta |
| description | : Teas are an essential part of traditional phytotherapy. The aim of this systematic review is to assess the clinical evidence using green tea catechins in cancer care.
: A systematic search was conducted searching five electronic databases concerning the effectiveness and risks of epigallocatechin gallate (EGCG) on cancer patients.
: Seven studies with 371 patients were included. Patients were mainly suffering from breast and prostate cancer. Dosing ranged from 28 mg to 1600 mg EGCG, intervention time from 7 days to 6 months with different applications (topical 2 studies; oral 5 studies). The studies showed heterogeneous methodological quality and results leading not to conduct a meta-analysis. There was a small decrease in prostate-specific-antigen levels in one study (N=60; T0:(mean±SD) 9.6±5.2 ng/ml, T1: 8.4±4.3 ng/ml vs. T0: 9.9±8.5 ng/ml, T1: 10.0±9.0 ng/ml; p=0.04), whereas in a second study only a trend was seen. Topical green tea was as effective as metronidazole powder in reducing the odor of fungating malignant wounds (1 study; N=30) with a consequent increase in quality of life (QoL) (p |
| doi_str_mv | 10.1024/0300-9831/a000698 |
| format | Article |
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: A systematic search was conducted searching five electronic databases concerning the effectiveness and risks of epigallocatechin gallate (EGCG) on cancer patients.
: Seven studies with 371 patients were included. Patients were mainly suffering from breast and prostate cancer. Dosing ranged from 28 mg to 1600 mg EGCG, intervention time from 7 days to 6 months with different applications (topical 2 studies; oral 5 studies). The studies showed heterogeneous methodological quality and results leading not to conduct a meta-analysis. There was a small decrease in prostate-specific-antigen levels in one study (N=60; T0:(mean±SD) 9.6±5.2 ng/ml, T1: 8.4±4.3 ng/ml vs. T0: 9.9±8.5 ng/ml, T1: 10.0±9.0 ng/ml; p=0.04), whereas in a second study only a trend was seen. Topical green tea was as effective as metronidazole powder in reducing the odor of fungating malignant wounds (1 study; N=30) with a consequent increase in quality of life (QoL) (p<0.001), improvement of appetite (p<0.001), malodorous control (p<0.001), social activities (p<0.001). Radiotherapy-induced diarrhea was lower in the green tea intervention group compared to placebo (1 study; N=42; week 4+5: without diarrhea p=0.002).
: The studies suggest that EGCG is as effective as a local antibiotic in malodorous control and improvement of QoL of fungating malignant wounds. Green tea could be a possible complementary method for treating acute radiation-induced diarrhea. Due to limitations, further studies with higher methodological quality and larger sample sizes are needed.</description><identifier>ISSN: 0300-9831</identifier><identifier>EISSN: 1664-2821</identifier><identifier>DOI: 10.1024/0300-9831/a000698</identifier><identifier>PMID: 33593083</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Antioxidants ; Humans ; Male ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Prostatic Neoplasms - drug therapy ; Quality of Life ; Tea</subject><ispartof>International journal for vitamin and nutrition research, 2023-02, Vol.93 (1), p.72-84</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-c54437ce1bd8c6c428f9edf24a517cae185efafbeab5a6b159d2e6007a1dd9cb3</citedby><cites>FETCH-LOGICAL-c367t-c54437ce1bd8c6c428f9edf24a517cae185efafbeab5a6b159d2e6007a1dd9cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33593083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiese, Fanny</creatorcontrib><creatorcontrib>Kutschan, Sabine</creatorcontrib><creatorcontrib>Doerfler, Jennifer</creatorcontrib><creatorcontrib>Mathies, Viktoria</creatorcontrib><creatorcontrib>Buentzel, Jens</creatorcontrib><creatorcontrib>Buentzel, Judith</creatorcontrib><creatorcontrib>Huebner, Jutta</creatorcontrib><title>Green tea and green tea extract in oncological treatment: A systematic review</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description>: Teas are an essential part of traditional phytotherapy. The aim of this systematic review is to assess the clinical evidence using green tea catechins in cancer care.
: A systematic search was conducted searching five electronic databases concerning the effectiveness and risks of epigallocatechin gallate (EGCG) on cancer patients.
: Seven studies with 371 patients were included. Patients were mainly suffering from breast and prostate cancer. Dosing ranged from 28 mg to 1600 mg EGCG, intervention time from 7 days to 6 months with different applications (topical 2 studies; oral 5 studies). The studies showed heterogeneous methodological quality and results leading not to conduct a meta-analysis. There was a small decrease in prostate-specific-antigen levels in one study (N=60; T0:(mean±SD) 9.6±5.2 ng/ml, T1: 8.4±4.3 ng/ml vs. T0: 9.9±8.5 ng/ml, T1: 10.0±9.0 ng/ml; p=0.04), whereas in a second study only a trend was seen. Topical green tea was as effective as metronidazole powder in reducing the odor of fungating malignant wounds (1 study; N=30) with a consequent increase in quality of life (QoL) (p<0.001), improvement of appetite (p<0.001), malodorous control (p<0.001), social activities (p<0.001). Radiotherapy-induced diarrhea was lower in the green tea intervention group compared to placebo (1 study; N=42; week 4+5: without diarrhea p=0.002).
: The studies suggest that EGCG is as effective as a local antibiotic in malodorous control and improvement of QoL of fungating malignant wounds. Green tea could be a possible complementary method for treating acute radiation-induced diarrhea. Due to limitations, further studies with higher methodological quality and larger sample sizes are needed.</description><subject>Antioxidants</subject><subject>Humans</subject><subject>Male</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Quality of Life</subject><subject>Tea</subject><issn>0300-9831</issn><issn>1664-2821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhS0EoqXwA1iQR5bQ69hxHLYKQUEqYoHZunFuqqA8iu0C_fe0aul0dHQew8fYtYA7AamaggRICiPFFAFAF-aEjYXWKklNKk7Z-JiP2EUInwAyF0ads5GUWSHByDF7nXuinkdCjn3Fl0dHv9Gji7zp-dC7oR2WjcOWR08YO-rjPZ_xsAmROoyN456-G_q5ZGc1toGuDjphH0-P7w_PyeJt_vIwWyRO6jwmLlNK5o5EWRmnnUpNXVBVpwozkTskYTKqsS4Jywx1KbKiSkkD5CiqqnClnLDb_e_KD19rCtF2TXDUttjTsA42VQVoUCY326rYV50fQvBU25VvOvQbK8DuKNodJbujZA8Ut5ubw_267Kg6Lv6xyT8HIW30</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Wiese, Fanny</creator><creator>Kutschan, Sabine</creator><creator>Doerfler, Jennifer</creator><creator>Mathies, Viktoria</creator><creator>Buentzel, Jens</creator><creator>Buentzel, Judith</creator><creator>Huebner, Jutta</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202302</creationdate><title>Green tea and green tea extract in oncological treatment: A systematic review</title><author>Wiese, Fanny ; Kutschan, Sabine ; Doerfler, Jennifer ; Mathies, Viktoria ; Buentzel, Jens ; Buentzel, Judith ; Huebner, Jutta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-c54437ce1bd8c6c428f9edf24a517cae185efafbeab5a6b159d2e6007a1dd9cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants</topic><topic>Humans</topic><topic>Male</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Quality of Life</topic><topic>Tea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiese, Fanny</creatorcontrib><creatorcontrib>Kutschan, Sabine</creatorcontrib><creatorcontrib>Doerfler, Jennifer</creatorcontrib><creatorcontrib>Mathies, Viktoria</creatorcontrib><creatorcontrib>Buentzel, Jens</creatorcontrib><creatorcontrib>Buentzel, Judith</creatorcontrib><creatorcontrib>Huebner, Jutta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiese, Fanny</au><au>Kutschan, Sabine</au><au>Doerfler, Jennifer</au><au>Mathies, Viktoria</au><au>Buentzel, Jens</au><au>Buentzel, Judith</au><au>Huebner, Jutta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green tea and green tea extract in oncological treatment: A systematic review</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>2023-02</date><risdate>2023</risdate><volume>93</volume><issue>1</issue><spage>72</spage><epage>84</epage><pages>72-84</pages><issn>0300-9831</issn><eissn>1664-2821</eissn><abstract>: Teas are an essential part of traditional phytotherapy. The aim of this systematic review is to assess the clinical evidence using green tea catechins in cancer care.
: A systematic search was conducted searching five electronic databases concerning the effectiveness and risks of epigallocatechin gallate (EGCG) on cancer patients.
: Seven studies with 371 patients were included. Patients were mainly suffering from breast and prostate cancer. Dosing ranged from 28 mg to 1600 mg EGCG, intervention time from 7 days to 6 months with different applications (topical 2 studies; oral 5 studies). The studies showed heterogeneous methodological quality and results leading not to conduct a meta-analysis. There was a small decrease in prostate-specific-antigen levels in one study (N=60; T0:(mean±SD) 9.6±5.2 ng/ml, T1: 8.4±4.3 ng/ml vs. T0: 9.9±8.5 ng/ml, T1: 10.0±9.0 ng/ml; p=0.04), whereas in a second study only a trend was seen. Topical green tea was as effective as metronidazole powder in reducing the odor of fungating malignant wounds (1 study; N=30) with a consequent increase in quality of life (QoL) (p<0.001), improvement of appetite (p<0.001), malodorous control (p<0.001), social activities (p<0.001). Radiotherapy-induced diarrhea was lower in the green tea intervention group compared to placebo (1 study; N=42; week 4+5: without diarrhea p=0.002).
: The studies suggest that EGCG is as effective as a local antibiotic in malodorous control and improvement of QoL of fungating malignant wounds. Green tea could be a possible complementary method for treating acute radiation-induced diarrhea. Due to limitations, further studies with higher methodological quality and larger sample sizes are needed.</abstract><cop>Switzerland</cop><pmid>33593083</pmid><doi>10.1024/0300-9831/a000698</doi><tpages>13</tpages></addata></record> |
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| subjects | Antioxidants Humans Male Plant Extracts - pharmacology Plant Extracts - therapeutic use Prostatic Neoplasms - drug therapy Quality of Life Tea |
| title | Green tea and green tea extract in oncological treatment: A systematic review |
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