CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway

Pain is a major complication of cancer and significantly affects the quality of life. Cerebrospinal fluid-contacting nucleus (CSF–CN) has been reported to be involved in the development of neuropathic pain and inflammatory pain. However, whether CSF-CN contributes to cancer-induced bone pain (CIBP)...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-04, Vol.547, p.36-43
Hauptverfasser:	Chen, Ping, Pan, Min, Lin, Qing-Song, Lin, Xian-Zhong, Lin, Zhangya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - cerebrospinal fluid Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer Pain - cerebrospinal fluid Cancer Pain - etiology Cancer Pain - metabolism Cancer Pain - pathology Cancer-induced bone pain Cell Nucleus - metabolism Cerebrospinal Fluid - metabolism Cerebrospinal fluid-contacting nucleus Disease Models, Animal Dual Specificity Phosphatase 1 - genetics Dual Specificity Phosphatase 1 - metabolism Female Hyperalgesia - cerebrospinal fluid Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - pathology MAP Kinase Signaling System MAPK Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism MKP-1 Morphine Pain Threshold Rats Rats, Sprague-Dawley
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