Biomimetic silk biomaterials: Perlecan-functionalized silk fibroin for use in blood-contacting devices

Blood compatible materials are required for the development of therapeutic and diagnostic blood contacting devices as blood-material interactions are a key factor dictating device functionality. In this work, we explored biofunctionalization of silk biomaterials with a recombinantly expressed domain...

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Veröffentlicht in:	Acta biomaterialia 2021-09, Vol.132, p.162-175
Hauptverfasser:	Lau, Kieran, Waterhouse, Anna, Akhavan, Behnam, Gao, Lingzi, Kim, Ha Na, Tang, Fengying, Whitelock, John M, Bilek, Marcela M, Lord, Megan S, Rnjak-Kovacina, Jelena
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Basement membrane Biomaterials Biomedical materials Biomimetic Biomimetics Blood Blood plasma Blood platelets Carbodiimide Compatibility Endothelial cells Immobilization Ion implantation Muscles Perlecan Plasma immersion ion implantation Platelets Proteins Proteoglycans Silk Silk fibroin Smooth muscle Surgical implants
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