Synthesis, characterization and cytotoxicity studies of Co(III)-flavonolato complexes

Hypoxia activated Co(III) complexes as prodrugs may provide with a selective delivery of cytotoxic or antibacterial compounds. Whithin this field sixteen novel Co(III) ternary complexes with the general formula [Co(4N)(flav)](ClO4)2, where 4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)...

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Veröffentlicht in:	Journal of inorganic biochemistry 2021-04, Vol.217, p.111382-111382, Article 111382
Hauptverfasser:	Kozsup, Máté, Zhou, XueQuan, Farkas, Etelka, Bényei, Attila Cs, Bonnet, Sylvestre, Patonay, Tamás, Kónya, Krisztina, Buglyó, Péter
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Cell Hypoxia - physiology Cell Line, Tumor Cobalt - chemistry CoIII complexes Coordination Complexes - chemical synthesis Coordination Complexes - pharmacology Flavonoids - chemical synthesis Flavonoids - pharmacology Flavonoles Humans Hypoxia activation Ligands Molecular Structure Oxidation-Reduction Redox behavior Stereoisomerism X-ray structures
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