Acute administration of the olive constituent, oleuropein, combined with ischemic postconditioning increases myocardial protection by modulating oxidative defense

Oleuropein, one of the main polyphenolic constituents of olive, is cardioprotective against ischemia reperfusion injury (IRI). We aimed to assess the cardioprotection afforded by acute administration of oleuropein and to evaluate the underlying mechanism. Importantly, since antioxidant therapies hav...

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Veröffentlicht in:	Free radical biology & medicine 2021-04, Vol.166, p.18-32
Hauptverfasser:	Tsoumani, Maria, Georgoulis, Anastasios, Nikolaou, Panagiota-Efstathia, Kostopoulos, Ioannis V., Dermintzoglou, Theano, Papatheodorou, Ioanna, Zoga, Anastasia, Efentakis, Panagiotis, Konstantinou, Maria, Gikas, Evangelos, Kostomitsopoulos, Nikolaos, Papapetropoulos, Andreas, Lazou, Antigone, Skaltsounis, Alexios- Leandros, Hausenloy, Derek J., Tsitsilonis, Ourania, Tseti, Ioulia, Di Lisa, Fabio, Iliodromitis, Efstathios K., Andreadou, Ioanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant defense systems Cardioprotection Inflammation Ischemia-reperfusion injury Oleuropein Postconditioning
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