Managing mucormycosis in diabetic patients: A case report with critical review of the literature
Background and Purpose Rhino–orbito–cerebral mucormycosis (ROCM) is a rare and potentially fatal invasive fungal infection which usually occurs in diabetic and other immunocompromised patients. This infection is associated with high morbidity and mortality rates. Prompt diagnosis and rapid aggressiv...
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| Veröffentlicht in: | Oral diseases 2022-04, Vol.28 (3), p.568-576 |
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| creator | Beiglboeck, Fabian M. Theofilou, Nantia E. Fuchs, Matthias D. Wiesli, Matthias G. Leiggener, Christoph Igelbrink, Sebastian Augello, Marcello |
| description | Background and Purpose
Rhino–orbito–cerebral mucormycosis (ROCM) is a rare and potentially fatal invasive fungal infection which usually occurs in diabetic and other immunocompromised patients. This infection is associated with high morbidity and mortality rates. Prompt diagnosis and rapid aggressive surgical debridement and antimycotic therapy are essential for the patient's survival.
Herein, we reviewed the localization and treatment strategies in patients with ROCM and diabetes as an underlying condition. Furthermore, we report one case of ROCM in our department.
Materials and Methods
From 117 identified studies published in PubMed, 14 publications—containing data from 54 patients—were included. All patients were diagnosed clinically and by histopathological and/or bacteriological analysis for ROCM caused by the order Mucorales.
Conclusion
Uncontrolled diabetes mellitus is one of the main risk factors for ROCM. A successful management of ROCM requires an early diagnosis, a prompt systemic antifungal therapy, and a rapid aggressive surgical debridement including exploration of the pterygopalatine fossa. An orbital exenteration may be necessary. |
| doi_str_mv | 10.1111/odi.13802 |
| format | Article |
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Rhino–orbito–cerebral mucormycosis (ROCM) is a rare and potentially fatal invasive fungal infection which usually occurs in diabetic and other immunocompromised patients. This infection is associated with high morbidity and mortality rates. Prompt diagnosis and rapid aggressive surgical debridement and antimycotic therapy are essential for the patient's survival.
Herein, we reviewed the localization and treatment strategies in patients with ROCM and diabetes as an underlying condition. Furthermore, we report one case of ROCM in our department.
Materials and Methods
From 117 identified studies published in PubMed, 14 publications—containing data from 54 patients—were included. All patients were diagnosed clinically and by histopathological and/or bacteriological analysis for ROCM caused by the order Mucorales.
Conclusion
Uncontrolled diabetes mellitus is one of the main risk factors for ROCM. A successful management of ROCM requires an early diagnosis, a prompt systemic antifungal therapy, and a rapid aggressive surgical debridement including exploration of the pterygopalatine fossa. An orbital exenteration may be necessary.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.13802</identifier><identifier>PMID: 33583133</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Antifungal Agents - therapeutic use ; Case reports ; Debridement ; dental ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diagnosis ; exenteration ; Fungal infections ; Humans ; Immunocompromised Host ; Immunocompromised hosts ; Literature reviews ; Localization ; Morbidity ; Mucormycosis ; Mucormycosis - complications ; Mucormycosis - diagnosis ; Mucormycosis - therapy ; Orbital Diseases - diagnosis ; Orbital Diseases - microbiology ; Orbital Diseases - therapy ; Patients ; rhino‐orbito‐cerebral ; rhizopus oryzae ; Risk factors</subject><ispartof>Oral diseases, 2022-04, Vol.28 (3), p.568-576</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Oral Diseases published by Wiley Periodicals LLC.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-e2576bd6dbfd61fd386bb0a38cce6863f0efb6a915ae8ebb28cfe8aa1880ce353</citedby><cites>FETCH-LOGICAL-c3532-e2576bd6dbfd61fd386bb0a38cce6863f0efb6a915ae8ebb28cfe8aa1880ce353</cites><orcidid>0000-0001-8587-8469</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.13802$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.13802$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33583133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beiglboeck, Fabian M.</creatorcontrib><creatorcontrib>Theofilou, Nantia E.</creatorcontrib><creatorcontrib>Fuchs, Matthias D.</creatorcontrib><creatorcontrib>Wiesli, Matthias G.</creatorcontrib><creatorcontrib>Leiggener, Christoph</creatorcontrib><creatorcontrib>Igelbrink, Sebastian</creatorcontrib><creatorcontrib>Augello, Marcello</creatorcontrib><title>Managing mucormycosis in diabetic patients: A case report with critical review of the literature</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Background and Purpose
Rhino–orbito–cerebral mucormycosis (ROCM) is a rare and potentially fatal invasive fungal infection which usually occurs in diabetic and other immunocompromised patients. This infection is associated with high morbidity and mortality rates. Prompt diagnosis and rapid aggressive surgical debridement and antimycotic therapy are essential for the patient's survival.
Herein, we reviewed the localization and treatment strategies in patients with ROCM and diabetes as an underlying condition. Furthermore, we report one case of ROCM in our department.
Materials and Methods
From 117 identified studies published in PubMed, 14 publications—containing data from 54 patients—were included. All patients were diagnosed clinically and by histopathological and/or bacteriological analysis for ROCM caused by the order Mucorales.
Conclusion
Uncontrolled diabetes mellitus is one of the main risk factors for ROCM. A successful management of ROCM requires an early diagnosis, a prompt systemic antifungal therapy, and a rapid aggressive surgical debridement including exploration of the pterygopalatine fossa. An orbital exenteration may be necessary.</description><subject>Antifungal Agents - therapeutic use</subject><subject>Case reports</subject><subject>Debridement</subject><subject>dental</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diagnosis</subject><subject>exenteration</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunocompromised hosts</subject><subject>Literature reviews</subject><subject>Localization</subject><subject>Morbidity</subject><subject>Mucormycosis</subject><subject>Mucormycosis - complications</subject><subject>Mucormycosis - diagnosis</subject><subject>Mucormycosis - therapy</subject><subject>Orbital Diseases - diagnosis</subject><subject>Orbital Diseases - microbiology</subject><subject>Orbital Diseases - therapy</subject><subject>Patients</subject><subject>rhino‐orbito‐cerebral</subject><subject>rhizopus oryzae</subject><subject>Risk factors</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kE1PGzEQQK2qqEDooX-gstQLHJb4I3a8vUUBWiRQLkXiZmzvLBjtrlPb2yj_HrdJOSDhy1ijp6fRQ-gLJee0vGlo_DnlirAP6IhKQiuimPhY_lzMKsH4_SE6TumZEDqvOfuEDjkXilPOj9DDrRnMox8ecT-6EPutC8kn7AfceGMhe4fXJnsYcvqOF9iZBDjCOsSMNz4_YRd9YUxXln88bHBocX4C3PkM0eQxwgk6aE2X4PN-TtDd1eWv5c_qZvXjerm4qRwXnFXAxFzaRja2bSRtG66ktcRw5RxIJXlLoLXS1FQYUGAtU64FZQxVijgoigk63XnXMfweIWXd--Sg68wAYUyazVQtasGpKui3N-hzGONQrtNMcskImcu6UGc7ysWQUoRWr6PvTdxqSvTf7Lpk1_-yF_br3jjaHppX8n_nAkx3wMZ3sH3fpFcX1zvlC1p5jSo</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Beiglboeck, Fabian M.</creator><creator>Theofilou, Nantia E.</creator><creator>Fuchs, Matthias D.</creator><creator>Wiesli, Matthias G.</creator><creator>Leiggener, Christoph</creator><creator>Igelbrink, Sebastian</creator><creator>Augello, Marcello</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8587-8469</orcidid></search><sort><creationdate>202204</creationdate><title>Managing mucormycosis in diabetic patients: A case report with critical review of the literature</title><author>Beiglboeck, Fabian M. ; Theofilou, Nantia E. ; Fuchs, Matthias D. ; Wiesli, Matthias G. ; Leiggener, Christoph ; Igelbrink, Sebastian ; Augello, Marcello</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-e2576bd6dbfd61fd386bb0a38cce6863f0efb6a915ae8ebb28cfe8aa1880ce353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antifungal Agents - therapeutic use</topic><topic>Case reports</topic><topic>Debridement</topic><topic>dental</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diagnosis</topic><topic>exenteration</topic><topic>Fungal infections</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunocompromised hosts</topic><topic>Literature reviews</topic><topic>Localization</topic><topic>Morbidity</topic><topic>Mucormycosis</topic><topic>Mucormycosis - complications</topic><topic>Mucormycosis - diagnosis</topic><topic>Mucormycosis - therapy</topic><topic>Orbital Diseases - diagnosis</topic><topic>Orbital Diseases - microbiology</topic><topic>Orbital Diseases - therapy</topic><topic>Patients</topic><topic>rhino‐orbito‐cerebral</topic><topic>rhizopus oryzae</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beiglboeck, Fabian M.</creatorcontrib><creatorcontrib>Theofilou, Nantia E.</creatorcontrib><creatorcontrib>Fuchs, Matthias D.</creatorcontrib><creatorcontrib>Wiesli, Matthias G.</creatorcontrib><creatorcontrib>Leiggener, Christoph</creatorcontrib><creatorcontrib>Igelbrink, Sebastian</creatorcontrib><creatorcontrib>Augello, Marcello</creatorcontrib><collection>Wiley-Blackwell Open Access Titles(OpenAccess)</collection><collection>Wiley Free Archive</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beiglboeck, Fabian M.</au><au>Theofilou, Nantia E.</au><au>Fuchs, Matthias D.</au><au>Wiesli, Matthias G.</au><au>Leiggener, Christoph</au><au>Igelbrink, Sebastian</au><au>Augello, Marcello</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Managing mucormycosis in diabetic patients: A case report with critical review of the literature</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2022-04</date><risdate>2022</risdate><volume>28</volume><issue>3</issue><spage>568</spage><epage>576</epage><pages>568-576</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Background and Purpose
Rhino–orbito–cerebral mucormycosis (ROCM) is a rare and potentially fatal invasive fungal infection which usually occurs in diabetic and other immunocompromised patients. This infection is associated with high morbidity and mortality rates. Prompt diagnosis and rapid aggressive surgical debridement and antimycotic therapy are essential for the patient's survival.
Herein, we reviewed the localization and treatment strategies in patients with ROCM and diabetes as an underlying condition. Furthermore, we report one case of ROCM in our department.
Materials and Methods
From 117 identified studies published in PubMed, 14 publications—containing data from 54 patients—were included. All patients were diagnosed clinically and by histopathological and/or bacteriological analysis for ROCM caused by the order Mucorales.
Conclusion
Uncontrolled diabetes mellitus is one of the main risk factors for ROCM. A successful management of ROCM requires an early diagnosis, a prompt systemic antifungal therapy, and a rapid aggressive surgical debridement including exploration of the pterygopalatine fossa. An orbital exenteration may be necessary.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33583133</pmid><doi>10.1111/odi.13802</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8587-8469</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral diseases, 2022-04, Vol.28 (3), p.568-576 |
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| source | MEDLINE; Wiley Blackwell Journals |
| subjects | Antifungal Agents - therapeutic use Case reports Debridement dental Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diagnosis exenteration Fungal infections Humans Immunocompromised Host Immunocompromised hosts Literature reviews Localization Morbidity Mucormycosis Mucormycosis - complications Mucormycosis - diagnosis Mucormycosis - therapy Orbital Diseases - diagnosis Orbital Diseases - microbiology Orbital Diseases - therapy Patients rhino‐orbito‐cerebral rhizopus oryzae Risk factors |
| title | Managing mucormycosis in diabetic patients: A case report with critical review of the literature |
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