Decreased pH in the aging brain and Alzheimer's disease

Using publicly available data sets, we compared pH in the human brain and the cerebrospinal fluid (CSF) of postmortem control and Alzheimer's disease cases. We further investigated the effects of long-term acidosis in vivo in the APP-PS1 mouse model of Alzheimer's disease. We finally exami...

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Veröffentlicht in:	Neurobiology of aging 2021-05, Vol.101, p.40-49
Hauptverfasser:	Decker, Yann, Németh, Eszter, Schomburg, Robert, Chemla, Axel, Fülöp, Lívia, Menger, Michael D., Liu, Yang, Fassbender, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Acidosis - metabolism Aging - metabolism Alzheimer Alzheimer Disease - metabolism Amyloid beta Amyloid beta-Peptides - metabolism Animals Brain Brain - metabolism Cerebrospinal Fluid - metabolism Cytokines - metabolism Disease Models, Animal Hydrogen-Ion Concentration Inflammation Inflammation Mediators - economics Inflammation Mediators - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microglia Microglia - metabolism
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