Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country
Purpose Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians’ perspectives on their effectiveness are scarce. Methods We retrospectively reviewed th...
Gespeichert in:
| Veröffentlicht in: | Child's nervous system 2021-05, Vol.37 (5), p.1573-1580 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1580 |
|---|---|
| container_issue | 5 |
| container_start_page | 1573 |
| container_title | Child's nervous system |
| container_volume | 37 |
| creator | Foo, Jen Chun Jawin, Vida Yap, Tsiao Yi Ahmad Bahuri, Nor Faizal Ganesan, Dharmendra Mun, Kein Seong Loh, Jasmin Azman, Raja Rizal Gottardo, Nicholas G. Qaddoumi, Ibrahim Moreira, Daniel C. Rajagopal, Revathi |
| description | Purpose
Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians’ perspectives on their effectiveness are scarce.
Methods
We retrospectively reviewed the clinical data of pediatric patients (aged |
| doi_str_mv | 10.1007/s00381-021-05080-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2489262396</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2489262396</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-67beb734e7921420a5f378576eaeea7c49be499e52ad3699aa54f544b59e8e1e3</originalsourceid><addsrcrecordid>eNp9UUuO1DAQtRCIaQYuwAJ5ySaD408SL1GLnzQSG1hbjlPp9sifxk6QejcHYY7BheYk1HQPLFlYJVe99-rzCHndsquWsf5dZUwMbcM4PsUG1sgnZNNKIRomFHtKNoyrrumZZBfkRa03jLVq4Po5uRBCDYhRG_J7m9O0uoXmmSZYS25ycjnk3ZHGNSx-8tX5Q_DJliNdwEYaARafdpXaNFEXcsUPXfZA729_7eyh3t_eUZ9OGYc872yg0Sa7gwjp1MftfZj2OSMdMwXrCcrPvFZaj3WBSJc15lIfVCyNfpoCNB6niqiYV2QcX5Jnsw0VXj3GS_L944dv28_N9ddPX7bvrxsnZL80XT_C2AsJveat5MyqWfSD6juwALZ3Uo8gtQbF7SQ6ra1VclZSjkrDAC2IS_L2rHso-ccKdTER7wEh2AQ4r-Fy0LzjQncI5WeoK7nWArM5FB_xaqZl5sEuc7bLoF3mZJeRSHrzqL-OEaZ_lL_-IECcARVLaQfF3OS1JNz5f7J_AIE-pwY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489262396</pqid></control><display><type>article</type><title>Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country</title><source>SpringerLink Journals - AutoHoldings</source><creator>Foo, Jen Chun ; Jawin, Vida ; Yap, Tsiao Yi ; Ahmad Bahuri, Nor Faizal ; Ganesan, Dharmendra ; Mun, Kein Seong ; Loh, Jasmin ; Azman, Raja Rizal ; Gottardo, Nicholas G. ; Qaddoumi, Ibrahim ; Moreira, Daniel C. ; Rajagopal, Revathi</creator><creatorcontrib>Foo, Jen Chun ; Jawin, Vida ; Yap, Tsiao Yi ; Ahmad Bahuri, Nor Faizal ; Ganesan, Dharmendra ; Mun, Kein Seong ; Loh, Jasmin ; Azman, Raja Rizal ; Gottardo, Nicholas G. ; Qaddoumi, Ibrahim ; Moreira, Daniel C. ; Rajagopal, Revathi</creatorcontrib><description>Purpose
Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians’ perspectives on their effectiveness are scarce.
Methods
We retrospectively reviewed the clinical data of pediatric patients (aged <18 years) with CNS tumors diagnosed and treated in the Pediatric Hematology-Oncology Division at the University Malaya Medical Center from 2008 to 2019. We also conducted a web-based survey of the core members of the multidisciplinary team to evaluate the impact of the MDTMs.
Results
During the pre-MDTM era (2008–2012), 29 CNS tumors were diagnosed and treated, and during the MDTM era (2014–2019), 49 CNS tumors were diagnosed and treated. The interval for histologic diagnosis was significantly shorter during the MDTM era (
p
=0.04), but the interval from diagnosis to chemotherapy or radiotherapy and the 5-year overall survival of the 78 patients did not improve (62.1% ± 9.0% vs. 68.8% ± 9.1%;
p
=0.184). However, the 5-year overall survival of patients with medulloblastoma or rare tumors significantly improved in the MDTM era (
p
=0.01). Key factors that contributed to delayed treatment and poor outcomes were postoperative complications, the facility’s lack of infrastructure, poor parental education about early treatment, cultural beliefs in alternative medicine, and infection during chemotherapy. Eighteen clinicians responded to the survey; they felt that the MDTMs were beneficial in decision-making and enhanced the continuity of coordinated care.
Conclusion
MDTMs significantly reduced the diagnostic interval and improved the overall outcomes. However, delayed treatment remains a major challenge that requires further attention.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-021-05080-4</identifier><identifier>PMID: 33580355</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Medicine ; Medicine & Public Health ; Neurosciences ; Neurosurgery ; Original Article</subject><ispartof>Child's nervous system, 2021-05, Vol.37 (5), p.1573-1580</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-67beb734e7921420a5f378576eaeea7c49be499e52ad3699aa54f544b59e8e1e3</citedby><cites>FETCH-LOGICAL-c347t-67beb734e7921420a5f378576eaeea7c49be499e52ad3699aa54f544b59e8e1e3</cites><orcidid>0000-0003-4380-4124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-021-05080-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-021-05080-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33580355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foo, Jen Chun</creatorcontrib><creatorcontrib>Jawin, Vida</creatorcontrib><creatorcontrib>Yap, Tsiao Yi</creatorcontrib><creatorcontrib>Ahmad Bahuri, Nor Faizal</creatorcontrib><creatorcontrib>Ganesan, Dharmendra</creatorcontrib><creatorcontrib>Mun, Kein Seong</creatorcontrib><creatorcontrib>Loh, Jasmin</creatorcontrib><creatorcontrib>Azman, Raja Rizal</creatorcontrib><creatorcontrib>Gottardo, Nicholas G.</creatorcontrib><creatorcontrib>Qaddoumi, Ibrahim</creatorcontrib><creatorcontrib>Moreira, Daniel C.</creatorcontrib><creatorcontrib>Rajagopal, Revathi</creatorcontrib><title>Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Purpose
Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians’ perspectives on their effectiveness are scarce.
Methods
We retrospectively reviewed the clinical data of pediatric patients (aged <18 years) with CNS tumors diagnosed and treated in the Pediatric Hematology-Oncology Division at the University Malaya Medical Center from 2008 to 2019. We also conducted a web-based survey of the core members of the multidisciplinary team to evaluate the impact of the MDTMs.
Results
During the pre-MDTM era (2008–2012), 29 CNS tumors were diagnosed and treated, and during the MDTM era (2014–2019), 49 CNS tumors were diagnosed and treated. The interval for histologic diagnosis was significantly shorter during the MDTM era (
p
=0.04), but the interval from diagnosis to chemotherapy or radiotherapy and the 5-year overall survival of the 78 patients did not improve (62.1% ± 9.0% vs. 68.8% ± 9.1%;
p
=0.184). However, the 5-year overall survival of patients with medulloblastoma or rare tumors significantly improved in the MDTM era (
p
=0.01). Key factors that contributed to delayed treatment and poor outcomes were postoperative complications, the facility’s lack of infrastructure, poor parental education about early treatment, cultural beliefs in alternative medicine, and infection during chemotherapy. Eighteen clinicians responded to the survey; they felt that the MDTMs were beneficial in decision-making and enhanced the continuity of coordinated care.
Conclusion
MDTMs significantly reduced the diagnostic interval and improved the overall outcomes. However, delayed treatment remains a major challenge that requires further attention.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UUuO1DAQtRCIaQYuwAJ5ySaD408SL1GLnzQSG1hbjlPp9sifxk6QejcHYY7BheYk1HQPLFlYJVe99-rzCHndsquWsf5dZUwMbcM4PsUG1sgnZNNKIRomFHtKNoyrrumZZBfkRa03jLVq4Po5uRBCDYhRG_J7m9O0uoXmmSZYS25ycjnk3ZHGNSx-8tX5Q_DJliNdwEYaARafdpXaNFEXcsUPXfZA729_7eyh3t_eUZ9OGYc872yg0Sa7gwjp1MftfZj2OSMdMwXrCcrPvFZaj3WBSJc15lIfVCyNfpoCNB6niqiYV2QcX5Jnsw0VXj3GS_L944dv28_N9ddPX7bvrxsnZL80XT_C2AsJveat5MyqWfSD6juwALZ3Uo8gtQbF7SQ6ra1VclZSjkrDAC2IS_L2rHso-ccKdTER7wEh2AQ4r-Fy0LzjQncI5WeoK7nWArM5FB_xaqZl5sEuc7bLoF3mZJeRSHrzqL-OEaZ_lL_-IECcARVLaQfF3OS1JNz5f7J_AIE-pwY</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Foo, Jen Chun</creator><creator>Jawin, Vida</creator><creator>Yap, Tsiao Yi</creator><creator>Ahmad Bahuri, Nor Faizal</creator><creator>Ganesan, Dharmendra</creator><creator>Mun, Kein Seong</creator><creator>Loh, Jasmin</creator><creator>Azman, Raja Rizal</creator><creator>Gottardo, Nicholas G.</creator><creator>Qaddoumi, Ibrahim</creator><creator>Moreira, Daniel C.</creator><creator>Rajagopal, Revathi</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4380-4124</orcidid></search><sort><creationdate>20210501</creationdate><title>Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country</title><author>Foo, Jen Chun ; Jawin, Vida ; Yap, Tsiao Yi ; Ahmad Bahuri, Nor Faizal ; Ganesan, Dharmendra ; Mun, Kein Seong ; Loh, Jasmin ; Azman, Raja Rizal ; Gottardo, Nicholas G. ; Qaddoumi, Ibrahim ; Moreira, Daniel C. ; Rajagopal, Revathi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-67beb734e7921420a5f378576eaeea7c49be499e52ad3699aa54f544b59e8e1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foo, Jen Chun</creatorcontrib><creatorcontrib>Jawin, Vida</creatorcontrib><creatorcontrib>Yap, Tsiao Yi</creatorcontrib><creatorcontrib>Ahmad Bahuri, Nor Faizal</creatorcontrib><creatorcontrib>Ganesan, Dharmendra</creatorcontrib><creatorcontrib>Mun, Kein Seong</creatorcontrib><creatorcontrib>Loh, Jasmin</creatorcontrib><creatorcontrib>Azman, Raja Rizal</creatorcontrib><creatorcontrib>Gottardo, Nicholas G.</creatorcontrib><creatorcontrib>Qaddoumi, Ibrahim</creatorcontrib><creatorcontrib>Moreira, Daniel C.</creatorcontrib><creatorcontrib>Rajagopal, Revathi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foo, Jen Chun</au><au>Jawin, Vida</au><au>Yap, Tsiao Yi</au><au>Ahmad Bahuri, Nor Faizal</au><au>Ganesan, Dharmendra</au><au>Mun, Kein Seong</au><au>Loh, Jasmin</au><au>Azman, Raja Rizal</au><au>Gottardo, Nicholas G.</au><au>Qaddoumi, Ibrahim</au><au>Moreira, Daniel C.</au><au>Rajagopal, Revathi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>37</volume><issue>5</issue><spage>1573</spage><epage>1580</epage><pages>1573-1580</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Purpose
Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians’ perspectives on their effectiveness are scarce.
Methods
We retrospectively reviewed the clinical data of pediatric patients (aged <18 years) with CNS tumors diagnosed and treated in the Pediatric Hematology-Oncology Division at the University Malaya Medical Center from 2008 to 2019. We also conducted a web-based survey of the core members of the multidisciplinary team to evaluate the impact of the MDTMs.
Results
During the pre-MDTM era (2008–2012), 29 CNS tumors were diagnosed and treated, and during the MDTM era (2014–2019), 49 CNS tumors were diagnosed and treated. The interval for histologic diagnosis was significantly shorter during the MDTM era (
p
=0.04), but the interval from diagnosis to chemotherapy or radiotherapy and the 5-year overall survival of the 78 patients did not improve (62.1% ± 9.0% vs. 68.8% ± 9.1%;
p
=0.184). However, the 5-year overall survival of patients with medulloblastoma or rare tumors significantly improved in the MDTM era (
p
=0.01). Key factors that contributed to delayed treatment and poor outcomes were postoperative complications, the facility’s lack of infrastructure, poor parental education about early treatment, cultural beliefs in alternative medicine, and infection during chemotherapy. Eighteen clinicians responded to the survey; they felt that the MDTMs were beneficial in decision-making and enhanced the continuity of coordinated care.
Conclusion
MDTMs significantly reduced the diagnostic interval and improved the overall outcomes. However, delayed treatment remains a major challenge that requires further attention.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33580355</pmid><doi>10.1007/s00381-021-05080-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4380-4124</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 2021-05, Vol.37 (5), p.1573-1580 |
| issn | 0256-7040 1433-0350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2489262396 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Medicine Medicine & Public Health Neurosciences Neurosurgery Original Article |
| title | Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A36%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Conduct%20of%20neuro-oncology%20multidisciplinary%20team%20meetings%20and%20closing%20the%20%E2%80%9Cgaps%E2%80%9D%20in%20the%20clinical%20management%20of%20childhood%20central%20nervous%20system%20tumors%20in%20a%20middle-income%20country&rft.jtitle=Child's%20nervous%20system&rft.au=Foo,%20Jen%20Chun&rft.date=2021-05-01&rft.volume=37&rft.issue=5&rft.spage=1573&rft.epage=1580&rft.pages=1573-1580&rft.issn=0256-7040&rft.eissn=1433-0350&rft_id=info:doi/10.1007/s00381-021-05080-4&rft_dat=%3Cproquest_cross%3E2489262396%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2489262396&rft_id=info:pmid/33580355&rfr_iscdi=true |