The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors

•DHEA is endogenous metabolite of fish ω-3 fatty acid DHA.•DHA and DHEA have similar chemical structure to the endogenous cannabinoids.•DHA and DHEA decreased seizure susceptibility of mice by activating CB1 receptors.•DHEA showed more potency than its parent lipid DHA. Docosahexaenoic acid (DHA) an...

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Veröffentlicht in:	Brain research bulletin 2021-05, Vol.170, p.74-80
Hauptverfasser:	Ghanbari, Mohammad-Mahdi, Loron, Ali Gharibi, Sayyah, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Antagonists - pharmacology Docosahexaenoic Acids - pharmacology Endocannabinoids Ethanolamide derivative Fatty Acids, Omega-3 - pharmacology Indoles - pharmacology Male Mice Pentylenetetrazole Piperidines - pharmacology Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - agonists Seizure threshold Seizures - chemically induced Seizures - drug therapy Seizures - metabolism ω-3 fatty acids
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