Impact of RIM-BPs in neuronal vesicles release
•RIM-BPs can maintain the structural integrity of the neuronal vesicle release area.•RIM-BPs are essential for high-fidelity of vesicles release and plasticity.•The transmission effect of RIM-BPs on forces-related neuronal vesicle release needs to be further discussed. Accurate signal transmission b...
Gespeichert in:
| Veröffentlicht in: | Brain research bulletin 2021-05, Vol.170, p.129-136 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 136 |
|---|---|
| container_issue | |
| container_start_page | 129 |
| container_title | Brain research bulletin |
| container_volume | 170 |
| creator | Gao, Tianyu Zhang, Zhengyao Yang, Yunong Zhang, Hangyu Li, Na Liu, Bo |
| description | •RIM-BPs can maintain the structural integrity of the neuronal vesicle release area.•RIM-BPs are essential for high-fidelity of vesicles release and plasticity.•The transmission effect of RIM-BPs on forces-related neuronal vesicle release needs to be further discussed.
Accurate signal transmission between neurons is accomplished by vesicle release with high spatiotemporal resolution in the central nervous system. The vesicle release occurs mainly in the active zone (AZ), a unique area on the presynaptic membrane. Many structural proteins expressed in the AZ connect with other proteins nearby. They can also regulate the precise release of vesicles through protein-protein interactions. RIM-binding proteins (RIM-BPs) are one of the essential proteins in the AZ. This review summarizes the structures and functions of three subtypes of RIM-BPs, including the interaction between RIM-BPs and other proteins such as Bassoon and voltage-gated calcium channel, their significance in stabilizing the AZ structure in the presynaptic region and collecting ion channels, and ultimately regulating the fusion and release of neuronal vesicles. |
| doi_str_mv | 10.1016/j.brainresbull.2021.02.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2489258013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0361923021000484</els_id><sourcerecordid>2489258013</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-203221dd138f7635afc29d950c4d47ee2becab91e8abab351df38a878195f1e43</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0EoqXwCyhixSbBY-fhsIPyqlQEQrC2HHsiuXKSYieV-HtStSCWrGZz7r2aQ8gF0AQo5FerpPLKth5DNTiXMMogoSyhwA7IFETBY1akxSGZUp5DXDJOJ-QkhBWlNBdZfkwmnGcCOPApSRbNWuk-6urobfEc376GyLZRi4PvWuWiDQarHYbIo0MV8JQc1coFPNvfGfl4uH-fP8XLl8fF_GYZay5oHzPKGQNjgIu6yHmmas1KU2ZUpyYtEFmFWlUloFCVqngGpuZCiUJAmdWAKZ-Ry13v2nefA4ZeNjZodE612A1BslSULBMU-Ihe71DtuxA81nLtbaP8lwQqt77kSv71Jbe-JGVy9DWGz_c7Q9Wg-Y3-CBqBux2A47cbi14GbbHVaKxH3UvT2f_sfAOtMYF4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489258013</pqid></control><display><type>article</type><title>Impact of RIM-BPs in neuronal vesicles release</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Gao, Tianyu ; Zhang, Zhengyao ; Yang, Yunong ; Zhang, Hangyu ; Li, Na ; Liu, Bo</creator><creatorcontrib>Gao, Tianyu ; Zhang, Zhengyao ; Yang, Yunong ; Zhang, Hangyu ; Li, Na ; Liu, Bo</creatorcontrib><description>•RIM-BPs can maintain the structural integrity of the neuronal vesicle release area.•RIM-BPs are essential for high-fidelity of vesicles release and plasticity.•The transmission effect of RIM-BPs on forces-related neuronal vesicle release needs to be further discussed.
Accurate signal transmission between neurons is accomplished by vesicle release with high spatiotemporal resolution in the central nervous system. The vesicle release occurs mainly in the active zone (AZ), a unique area on the presynaptic membrane. Many structural proteins expressed in the AZ connect with other proteins nearby. They can also regulate the precise release of vesicles through protein-protein interactions. RIM-binding proteins (RIM-BPs) are one of the essential proteins in the AZ. This review summarizes the structures and functions of three subtypes of RIM-BPs, including the interaction between RIM-BPs and other proteins such as Bassoon and voltage-gated calcium channel, their significance in stabilizing the AZ structure in the presynaptic region and collecting ion channels, and ultimately regulating the fusion and release of neuronal vesicles.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/j.brainresbull.2021.02.012</identifier><identifier>PMID: 33581313</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Active zone ; Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Neurons - metabolism ; RIM-binding proteins ; Synapse ; Synaptic Transmission - physiology ; Synaptic Vesicles - metabolism ; Vesicle release ; Voltage-gated calcium channel</subject><ispartof>Brain research bulletin, 2021-05, Vol.170, p.129-136</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-203221dd138f7635afc29d950c4d47ee2becab91e8abab351df38a878195f1e43</citedby><cites>FETCH-LOGICAL-c380t-203221dd138f7635afc29d950c4d47ee2becab91e8abab351df38a878195f1e43</cites><orcidid>0000-0002-5392-8019</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0361923021000484$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33581313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Tianyu</creatorcontrib><creatorcontrib>Zhang, Zhengyao</creatorcontrib><creatorcontrib>Yang, Yunong</creatorcontrib><creatorcontrib>Zhang, Hangyu</creatorcontrib><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Liu, Bo</creatorcontrib><title>Impact of RIM-BPs in neuronal vesicles release</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>•RIM-BPs can maintain the structural integrity of the neuronal vesicle release area.•RIM-BPs are essential for high-fidelity of vesicles release and plasticity.•The transmission effect of RIM-BPs on forces-related neuronal vesicle release needs to be further discussed.
Accurate signal transmission between neurons is accomplished by vesicle release with high spatiotemporal resolution in the central nervous system. The vesicle release occurs mainly in the active zone (AZ), a unique area on the presynaptic membrane. Many structural proteins expressed in the AZ connect with other proteins nearby. They can also regulate the precise release of vesicles through protein-protein interactions. RIM-binding proteins (RIM-BPs) are one of the essential proteins in the AZ. This review summarizes the structures and functions of three subtypes of RIM-BPs, including the interaction between RIM-BPs and other proteins such as Bassoon and voltage-gated calcium channel, their significance in stabilizing the AZ structure in the presynaptic region and collecting ion channels, and ultimately regulating the fusion and release of neuronal vesicles.</description><subject>Active zone</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>Neurons - metabolism</subject><subject>RIM-binding proteins</subject><subject>Synapse</subject><subject>Synaptic Transmission - physiology</subject><subject>Synaptic Vesicles - metabolism</subject><subject>Vesicle release</subject><subject>Voltage-gated calcium channel</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwCyhixSbBY-fhsIPyqlQEQrC2HHsiuXKSYieV-HtStSCWrGZz7r2aQ8gF0AQo5FerpPLKth5DNTiXMMogoSyhwA7IFETBY1akxSGZUp5DXDJOJ-QkhBWlNBdZfkwmnGcCOPApSRbNWuk-6urobfEc376GyLZRi4PvWuWiDQarHYbIo0MV8JQc1coFPNvfGfl4uH-fP8XLl8fF_GYZay5oHzPKGQNjgIu6yHmmas1KU2ZUpyYtEFmFWlUloFCVqngGpuZCiUJAmdWAKZ-Ry13v2nefA4ZeNjZodE612A1BslSULBMU-Ihe71DtuxA81nLtbaP8lwQqt77kSv71Jbe-JGVy9DWGz_c7Q9Wg-Y3-CBqBux2A47cbi14GbbHVaKxH3UvT2f_sfAOtMYF4</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Gao, Tianyu</creator><creator>Zhang, Zhengyao</creator><creator>Yang, Yunong</creator><creator>Zhang, Hangyu</creator><creator>Li, Na</creator><creator>Liu, Bo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5392-8019</orcidid></search><sort><creationdate>202105</creationdate><title>Impact of RIM-BPs in neuronal vesicles release</title><author>Gao, Tianyu ; Zhang, Zhengyao ; Yang, Yunong ; Zhang, Hangyu ; Li, Na ; Liu, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-203221dd138f7635afc29d950c4d47ee2becab91e8abab351df38a878195f1e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Active zone</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Animals</topic><topic>Neurons - metabolism</topic><topic>RIM-binding proteins</topic><topic>Synapse</topic><topic>Synaptic Transmission - physiology</topic><topic>Synaptic Vesicles - metabolism</topic><topic>Vesicle release</topic><topic>Voltage-gated calcium channel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Tianyu</creatorcontrib><creatorcontrib>Zhang, Zhengyao</creatorcontrib><creatorcontrib>Yang, Yunong</creatorcontrib><creatorcontrib>Zhang, Hangyu</creatorcontrib><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Liu, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Tianyu</au><au>Zhang, Zhengyao</au><au>Yang, Yunong</au><au>Zhang, Hangyu</au><au>Li, Na</au><au>Liu, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of RIM-BPs in neuronal vesicles release</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2021-05</date><risdate>2021</risdate><volume>170</volume><spage>129</spage><epage>136</epage><pages>129-136</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>•RIM-BPs can maintain the structural integrity of the neuronal vesicle release area.•RIM-BPs are essential for high-fidelity of vesicles release and plasticity.•The transmission effect of RIM-BPs on forces-related neuronal vesicle release needs to be further discussed.
Accurate signal transmission between neurons is accomplished by vesicle release with high spatiotemporal resolution in the central nervous system. The vesicle release occurs mainly in the active zone (AZ), a unique area on the presynaptic membrane. Many structural proteins expressed in the AZ connect with other proteins nearby. They can also regulate the precise release of vesicles through protein-protein interactions. RIM-binding proteins (RIM-BPs) are one of the essential proteins in the AZ. This review summarizes the structures and functions of three subtypes of RIM-BPs, including the interaction between RIM-BPs and other proteins such as Bassoon and voltage-gated calcium channel, their significance in stabilizing the AZ structure in the presynaptic region and collecting ion channels, and ultimately regulating the fusion and release of neuronal vesicles.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33581313</pmid><doi>10.1016/j.brainresbull.2021.02.012</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5392-8019</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 2021-05, Vol.170, p.129-136 |
| issn | 0361-9230 1873-2747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2489258013 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Active zone Adaptor Proteins, Signal Transducing - metabolism Animals Neurons - metabolism RIM-binding proteins Synapse Synaptic Transmission - physiology Synaptic Vesicles - metabolism Vesicle release Voltage-gated calcium channel |
| title | Impact of RIM-BPs in neuronal vesicles release |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T21%3A52%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20RIM-BPs%20in%20neuronal%20vesicles%20release&rft.jtitle=Brain%20research%20bulletin&rft.au=Gao,%20Tianyu&rft.date=2021-05&rft.volume=170&rft.spage=129&rft.epage=136&rft.pages=129-136&rft.issn=0361-9230&rft.eissn=1873-2747&rft_id=info:doi/10.1016/j.brainresbull.2021.02.012&rft_dat=%3Cproquest_cross%3E2489258013%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2489258013&rft_id=info:pmid/33581313&rft_els_id=S0361923021000484&rfr_iscdi=true |