Pharmacological evidence of a cholinergic contribution to elevated impulsivity and risky decision-making caused by adding win-paired cues to a rat gambling task

Background: Pairing rewards with sensory stimulation, in the form of auditory and visual cues, increases risky decision-making in both rats and humans. Understanding the neurobiological basis of this effect could help explain why electronic gambling machines are so addictive, and inform treatment de...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2021-06, Vol.35 (6), p.701-712
Hauptverfasser:	Betts, Graeme D, Hynes, Tristan J, Winstanley, Catharine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Agonists Animals Behavior, Addictive - physiopathology Choice Behavior - drug effects Cholinergic transmission Cues Decision making Decision Making - drug effects Decision Making - physiology Dopamine Drug addiction Gambling Gambling - physiopathology Gaming machines Impulsive behavior Impulsive Behavior - drug effects Impulsivity Latency Male Mecamylamine Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology Nicotine Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Oxotremorine Rats Rats, Long-Evans Reinforcement Reward Scopolamine Sensory integration Visual stimuli
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