Two patients with Papillon–Lefèvre syndrome without periodontal involvement of the permanent dentition

Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive genodermatosis characterized by palmoplantar keratoderma and severe periodontitis leading to premature loss of primary and permanent teeth. PLS is caused by loss‐of‐function mutations in CTSC, lacking functional cathepsin C, which impairs...

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