Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients
Background and Aims Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver fibrosis and explore the predicting factors for advance...
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| Veröffentlicht in: | Digestive diseases and sciences 2021-12, Vol.66 (12), p.4492-4500 |
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| creator | Chen, Yi-Cheng Hsu, Chao-Wei Jeng, Wen-Juei Lin, Chun-Yen |
| description | Background and Aims
Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver fibrosis and explore the predicting factors for advanced fibrosis.
Methods
CHB patients undergoing liver biopsy with complete assessments of HS, necroinflammation grade [histological activity index (HAI) score], and fibrosis stage were retrospectively recruited. Logistic regression analysis was performed to determine the factors associated with advanced liver fibrosis.
Results
In this cohort of 672 patients, 342 (50.9%) had HS and 267 (39.4%) were of advanced liver fibrosis. Age [odds ratio (OR) 1.026, 95% confidence interval (CI) 1.007–1.046,
p
= 0.008], body mass index (BMI, OR 1.091, 95% CI 1.026–1.159,
p
= 0.005), genotype (C vs. B) (OR 2.790, 95% CI 1.847–4.214,
p
|
| doi_str_mv | 10.1007/s10620-020-06761-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2488563409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712933433</galeid><sourcerecordid>A712933433</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-765fe7b0fdc97a82ba8a555ee063b761a012aa44ee0d5ead1a12656a8f4ff0493</originalsourceid><addsrcrecordid>eNp9UV1r1UAQXUSxt9U_4IMs-OJL6n4nebxe7AdcqqA-L5Nk0m65yV53N_0Af7wbUlsUkWXY4cw5w8wcQt5wdswZKz9EzoxgBZvDlIYXd8_IiutSFkKb6jlZMW5yzrk5IIcxXjPG6pKbl-RASm1qY9SK_Fx3NzC22NGtu8FAT1wTfHSRnke6jtG3DlIu3rp0RS-wDd6N_Q6GAZIP9_Q0QIe0mRK98Ime4R6Sa-nXhLk8N3Ej3VwFP2ZwKaYMfqRfcoZjiq_Iix52EV8__Efk-8mnb5uzYvv59Hyz3hatUiIVpdE9lg3ru7YuoRINVKC1RmRGNnlvYFwAKJWBTiN0HLgw2kDVq75nqpZH5P3Sdx_8jwljsoOLLe52MKKfohWqqrSRis3Ud39Rr_0UxjydFbo2FReyVk-sS9ihzSfxKUA7N7XrkotaSiVlZh3_g5Vfh4Nr_Yi9y_gfArEI8p1jDNjbfXADhHvLmZ0tt4vlls0xW27vsujtw8RTM2D3KPntcSbIhRBzabzE8LTSf9r-Agg_tmI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2596812394</pqid></control><display><type>article</type><title>Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients</title><source>SpringerNature Journals</source><creator>Chen, Yi-Cheng ; Hsu, Chao-Wei ; Jeng, Wen-Juei ; Lin, Chun-Yen</creator><creatorcontrib>Chen, Yi-Cheng ; Hsu, Chao-Wei ; Jeng, Wen-Juei ; Lin, Chun-Yen</creatorcontrib><description>Background and Aims
Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver fibrosis and explore the predicting factors for advanced fibrosis.
Methods
CHB patients undergoing liver biopsy with complete assessments of HS, necroinflammation grade [histological activity index (HAI) score], and fibrosis stage were retrospectively recruited. Logistic regression analysis was performed to determine the factors associated with advanced liver fibrosis.
Results
In this cohort of 672 patients, 342 (50.9%) had HS and 267 (39.4%) were of advanced liver fibrosis. Age [odds ratio (OR) 1.026, 95% confidence interval (CI) 1.007–1.046,
p
= 0.008], body mass index (BMI, OR 1.091, 95% CI 1.026–1.159,
p
= 0.005), genotype (C vs. B) (OR 2.790, 95% CI 1.847–4.214,
p
< 0.001), platelet (OR 0.986, 95% CI 0.982–0.991,
p
< 0.001), and HAI score (OR 1.197, 95% CI 1.114–1.285,
p
< 0.001) were independent factors for advanced liver fibrosis in multivariate logistic regression analysis. HAI score was also a significantly associated factor for significant liver fibrosis in non-cirrhotic subpopulation (OR 1.578, 95% CI 1.375–1.810,
p
< 0.001). HS was not related to advanced/significant liver fibrosis in overall/non-cirrhotic population (
p
> 0.05).
Conclusions
Significant or advanced liver fibrosis is associated with grade of necroinflammation but not with HS in CHB patients.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-020-06761-x</identifier><identifier>PMID: 33569664</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Biochemistry ; Development and progression ; Fibrosis ; Gastroenterology ; Hepatitis ; Hepatitis B ; Hepatology ; Interferon ; Liver ; Liver cirrhosis ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Oncology ; Original Article ; Regression analysis ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2021-12, Vol.66 (12), p.4492-4500</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-765fe7b0fdc97a82ba8a555ee063b761a012aa44ee0d5ead1a12656a8f4ff0493</citedby><cites>FETCH-LOGICAL-c442t-765fe7b0fdc97a82ba8a555ee063b761a012aa44ee0d5ead1a12656a8f4ff0493</cites><orcidid>0000-0002-7810-7145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-020-06761-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-020-06761-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33569664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yi-Cheng</creatorcontrib><creatorcontrib>Hsu, Chao-Wei</creatorcontrib><creatorcontrib>Jeng, Wen-Juei</creatorcontrib><creatorcontrib>Lin, Chun-Yen</creatorcontrib><title>Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background and Aims
Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver fibrosis and explore the predicting factors for advanced fibrosis.
Methods
CHB patients undergoing liver biopsy with complete assessments of HS, necroinflammation grade [histological activity index (HAI) score], and fibrosis stage were retrospectively recruited. Logistic regression analysis was performed to determine the factors associated with advanced liver fibrosis.
Results
In this cohort of 672 patients, 342 (50.9%) had HS and 267 (39.4%) were of advanced liver fibrosis. Age [odds ratio (OR) 1.026, 95% confidence interval (CI) 1.007–1.046,
p
= 0.008], body mass index (BMI, OR 1.091, 95% CI 1.026–1.159,
p
= 0.005), genotype (C vs. B) (OR 2.790, 95% CI 1.847–4.214,
p
< 0.001), platelet (OR 0.986, 95% CI 0.982–0.991,
p
< 0.001), and HAI score (OR 1.197, 95% CI 1.114–1.285,
p
< 0.001) were independent factors for advanced liver fibrosis in multivariate logistic regression analysis. HAI score was also a significantly associated factor for significant liver fibrosis in non-cirrhotic subpopulation (OR 1.578, 95% CI 1.375–1.810,
p
< 0.001). HS was not related to advanced/significant liver fibrosis in overall/non-cirrhotic population (
p
> 0.05).
Conclusions
Significant or advanced liver fibrosis is associated with grade of necroinflammation but not with HS in CHB patients.</description><subject>Analysis</subject><subject>Biochemistry</subject><subject>Development and progression</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatology</subject><subject>Interferon</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Regression analysis</subject><subject>Transplant Surgery</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UV1r1UAQXUSxt9U_4IMs-OJL6n4nebxe7AdcqqA-L5Nk0m65yV53N_0Af7wbUlsUkWXY4cw5w8wcQt5wdswZKz9EzoxgBZvDlIYXd8_IiutSFkKb6jlZMW5yzrk5IIcxXjPG6pKbl-RASm1qY9SK_Fx3NzC22NGtu8FAT1wTfHSRnke6jtG3DlIu3rp0RS-wDd6N_Q6GAZIP9_Q0QIe0mRK98Ime4R6Sa-nXhLk8N3Ej3VwFP2ZwKaYMfqRfcoZjiq_Iix52EV8__Efk-8mnb5uzYvv59Hyz3hatUiIVpdE9lg3ru7YuoRINVKC1RmRGNnlvYFwAKJWBTiN0HLgw2kDVq75nqpZH5P3Sdx_8jwljsoOLLe52MKKfohWqqrSRis3Ud39Rr_0UxjydFbo2FReyVk-sS9ihzSfxKUA7N7XrkotaSiVlZh3_g5Vfh4Nr_Yi9y_gfArEI8p1jDNjbfXADhHvLmZ0tt4vlls0xW27vsujtw8RTM2D3KPntcSbIhRBzabzE8LTSf9r-Agg_tmI</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Chen, Yi-Cheng</creator><creator>Hsu, Chao-Wei</creator><creator>Jeng, Wen-Juei</creator><creator>Lin, Chun-Yen</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7810-7145</orcidid></search><sort><creationdate>20211201</creationdate><title>Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients</title><author>Chen, Yi-Cheng ; Hsu, Chao-Wei ; Jeng, Wen-Juei ; Lin, Chun-Yen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-765fe7b0fdc97a82ba8a555ee063b761a012aa44ee0d5ead1a12656a8f4ff0493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Biochemistry</topic><topic>Development and progression</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatology</topic><topic>Interferon</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Regression analysis</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yi-Cheng</creatorcontrib><creatorcontrib>Hsu, Chao-Wei</creatorcontrib><creatorcontrib>Jeng, Wen-Juei</creatorcontrib><creatorcontrib>Lin, Chun-Yen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yi-Cheng</au><au>Hsu, Chao-Wei</au><au>Jeng, Wen-Juei</au><au>Lin, Chun-Yen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>66</volume><issue>12</issue><spage>4492</spage><epage>4500</epage><pages>4492-4500</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Background and Aims
Patients with chronic hepatitis B (CHB) are at an increased risk of disease progression. The influence of hepatic steatosis (HS) to liver fibrosis was controversial. We aim to investigate the association between HS and liver fibrosis and explore the predicting factors for advanced fibrosis.
Methods
CHB patients undergoing liver biopsy with complete assessments of HS, necroinflammation grade [histological activity index (HAI) score], and fibrosis stage were retrospectively recruited. Logistic regression analysis was performed to determine the factors associated with advanced liver fibrosis.
Results
In this cohort of 672 patients, 342 (50.9%) had HS and 267 (39.4%) were of advanced liver fibrosis. Age [odds ratio (OR) 1.026, 95% confidence interval (CI) 1.007–1.046,
p
= 0.008], body mass index (BMI, OR 1.091, 95% CI 1.026–1.159,
p
= 0.005), genotype (C vs. B) (OR 2.790, 95% CI 1.847–4.214,
p
< 0.001), platelet (OR 0.986, 95% CI 0.982–0.991,
p
< 0.001), and HAI score (OR 1.197, 95% CI 1.114–1.285,
p
< 0.001) were independent factors for advanced liver fibrosis in multivariate logistic regression analysis. HAI score was also a significantly associated factor for significant liver fibrosis in non-cirrhotic subpopulation (OR 1.578, 95% CI 1.375–1.810,
p
< 0.001). HS was not related to advanced/significant liver fibrosis in overall/non-cirrhotic population (
p
> 0.05).
Conclusions
Significant or advanced liver fibrosis is associated with grade of necroinflammation but not with HS in CHB patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33569664</pmid><doi>10.1007/s10620-020-06761-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7810-7145</orcidid></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2021-12, Vol.66 (12), p.4492-4500 |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Analysis Biochemistry Development and progression Fibrosis Gastroenterology Hepatitis Hepatitis B Hepatology Interferon Liver Liver cirrhosis Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Original Article Regression analysis Transplant Surgery |
| title | Advanced Liver Fibrosis Is Associated with Necroinflammatory Grade but Not Hepatic Steatosis in Chronic Hepatitis B Patients |
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