Diverse Synthesis of Chiral Trifluoromethylated Alkanes via Nickel‐Catalyzed Asymmetric Reductive Cross‐Coupling Fluoroalkylation

The trifluoromethyl group represents one of the most functional and widely used fluoroalkyl groups in drug design and screening, while the drug candidates containing chiral trifluoromethyl‐bearing carbons are still few due to the lack of efficient methods for the asymmetric introduction of trifluoro...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (18), p.9947-9952
Hauptverfasser:	Min, Yue, Sheng, Jie, Yu, Jian‐Liang, Ni, Shan‐Xiu, Ma, Guobin, Gong, Hegui, Wang, Xi‐Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes asymmetric trifluorofluoroalkylation Asymmetry Coupling (molecular) Cross coupling Drug development Enantiomers Functional groups Iodides late-stage fluoroalkylation Nickel Organic chemistry reductive cross-coupling Substrates
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