Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols

Incorporation of structurally novel noncanonical amino acids (ncAAs) into proteins is valuable for both scientific and biomedical applications. To expand the structural diversity of available ncAAs and to reduce the burden of chemically synthesizing them, we have developed a general and simple biosy...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (18), p.10040-10048
Hauptverfasser:	Wang, Yong, Chen, Xiaoxu, Cai, Wenkang, Tan, Linzhi, Yu, Yutong, Han, Boyang, Li, Yuxuan, Xie, Yuanzhe, Su, Yeyu, Luo, Xiaozhou, Liu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids aminoacyl-tRNA synthetase Antibodies Biomedical materials bioorthogonal conjugation biosynthesis Conjugation Fluorescence Genetic code genetic code expansion Green fluorescent protein Ketones noncanonical amino acids Proteins Thiols
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