Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE‐TR substudy
Background and aims The Friedewald equation (LDL‐Cf) is known to produce inaccurate estimations of low‐density lipoprotein cholesterol (LDL‐C) when triglycerides are high (>400 mg/dL) or LDL‐C is low (
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-06, Vol.75 (6), p.e14090-n/a |
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| container_title | International journal of clinical practice (Esher) |
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| creator | Dinç Asarcıklı, Lale Kış, Mehmet Güvenç, Tolga Sinan Tosun, Veysel Acar, Burak Avcı Demir, Fulya Naser, Abdulrahman Zoghi, Mehdi |
| description | Background and aims
The Friedewald equation (LDL‐Cf) is known to produce inaccurate estimations of low‐density lipoprotein cholesterol (LDL‐C) when triglycerides are high (>400 mg/dL) or LDL‐C is low ( |
| doi_str_mv | 10.1111/ijcp.14090 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2488551305</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2488551305</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3930-226ed22b50312b79bc56acd7ccd647bf23d85ce02c1c8b00c79d1ae4d9b88f963</originalsourceid><addsrcrecordid>eNp9kctO3TAQhi3UCiiw4QEqS92gSgFf4sRhhyIoVCAqblvLsZ3Khxw72HHR2XXRB-AZeZL6cCgLFp3NjGY-_ZqZH4BdjPZxjgM7U-M-LlGD1sAmrktSYFLiD7mmFS8YongDfIpxhhBhjKN1sEEpqxGnbBP8uY2mT4MzMULfQ-d_mQFeyDBZd3Dqx3vrIpROw2s5H6N30DwkOVmfu5kM8CRYo82jHPTbBFoHlQza-sH_XECfpjH3jZviITyC7d11e3l1_Pz76eYKxtTFKenFNvjYyyGande8BW5Pjm_a0-L88ttZe3ReKNpQVBBSGU1It7yIdHXTKVZJpWuldFXWXU-o5kwZRBRWvENI1Y3G0pS66Tjvm4pugb2V7hj8QzJxEnMblRkG6YxPUZCSc8YwRSyjX96hM5-Cy9sJwgjPzyMv1NcVpYKPMZhejMHOZVgIjMTSG7H0Rrx4k-HPr5Kpmxv9hv4zIwN4BTzawSz-IyXOvrc_VqJ_Aedym5o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2528083205</pqid></control><display><type>article</type><title>Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE‐TR substudy</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Dinç Asarcıklı, Lale ; Kış, Mehmet ; Güvenç, Tolga Sinan ; Tosun, Veysel ; Acar, Burak ; Avcı Demir, Fulya ; Naser, Abdulrahman ; Zoghi, Mehdi</creator><creatorcontrib>Dinç Asarcıklı, Lale ; Kış, Mehmet ; Güvenç, Tolga Sinan ; Tosun, Veysel ; Acar, Burak ; Avcı Demir, Fulya ; Naser, Abdulrahman ; Zoghi, Mehdi ; CVSCORE-TR investigators ; CVSCORE‐TR investigators</creatorcontrib><description>Background and aims
The Friedewald equation (LDL‐Cf) is known to produce inaccurate estimations of low‐density lipoprotein cholesterol (LDL‐C) when triglycerides are high (>400 mg/dL) or LDL‐C is low (<70 mg/dL). The Martin/Hopkins (LDL‐Cmh) and Sampson (LDL‐Cs) equations were developed to overcome these limitations, but few data are available to assess whether these equations offer incremental usefulness over LDL‐Cf. Our aim was to understand whether there was any incremental usefulness of novel equations on decisions regarding patient management.
Methods
Four thousand one hundred and ninety‐six cardiology patients who were included in a multicentre registry database were analysed. Each patient was assigned to a cardiovascular risk class using the SCORE (Systematic COronary Risk Evaluation) algorithm, and relevant European guidelines were used to assess LDL‐C targets.
Results
Compared with LDL‐Cmh and LDL‐Cs, LDL‐Cf was able to correctly identify 96.9%‐98.08% of patients as within or outside the LDL‐C target, respectively, and 1.95%‐2.8% of patients were falsely identified as being within the LDL‐C target. Kappa coefficients for agreement between LDL‐Cf vs LDL‐Cmh and LDL‐Cf vs LDL‐Cs were 0.868 and 0.918 (P < .001). For patients not on cholesterol‐lowering drugs, the decision to initiate treatment would be different in 1.2%‐1.8% of cases if LDL‐Cs or LDL‐Cmh were used, respectively. For those already on cholesterol‐lowering drugs, decisions regarding treatment intensification would be different in 1.5%‐2.4% of cases if LDL‐Cs or LDL‐Cmh were used.
Conclusions
In most cardiology outpatients, the Friedewald equation has excellent agreement with the novel Martin/Hopkins and Sampson equations, and treatment decisions should not change in most patients.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14090</identifier><identifier>PMID: 33570835</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Cardiology ; Cardiovascular diseases ; Cholesterol ; Low density lipoprotein ; Patients ; Triglycerides</subject><ispartof>International journal of clinical practice (Esher), 2021-06, Vol.75 (6), p.e14090-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3930-226ed22b50312b79bc56acd7ccd647bf23d85ce02c1c8b00c79d1ae4d9b88f963</citedby><cites>FETCH-LOGICAL-c3930-226ed22b50312b79bc56acd7ccd647bf23d85ce02c1c8b00c79d1ae4d9b88f963</cites><orcidid>0000-0002-7828-9487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14090$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14090$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33570835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dinç Asarcıklı, Lale</creatorcontrib><creatorcontrib>Kış, Mehmet</creatorcontrib><creatorcontrib>Güvenç, Tolga Sinan</creatorcontrib><creatorcontrib>Tosun, Veysel</creatorcontrib><creatorcontrib>Acar, Burak</creatorcontrib><creatorcontrib>Avcı Demir, Fulya</creatorcontrib><creatorcontrib>Naser, Abdulrahman</creatorcontrib><creatorcontrib>Zoghi, Mehdi</creatorcontrib><creatorcontrib>CVSCORE-TR investigators</creatorcontrib><creatorcontrib>CVSCORE‐TR investigators</creatorcontrib><title>Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE‐TR substudy</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Background and aims
The Friedewald equation (LDL‐Cf) is known to produce inaccurate estimations of low‐density lipoprotein cholesterol (LDL‐C) when triglycerides are high (>400 mg/dL) or LDL‐C is low (<70 mg/dL). The Martin/Hopkins (LDL‐Cmh) and Sampson (LDL‐Cs) equations were developed to overcome these limitations, but few data are available to assess whether these equations offer incremental usefulness over LDL‐Cf. Our aim was to understand whether there was any incremental usefulness of novel equations on decisions regarding patient management.
Methods
Four thousand one hundred and ninety‐six cardiology patients who were included in a multicentre registry database were analysed. Each patient was assigned to a cardiovascular risk class using the SCORE (Systematic COronary Risk Evaluation) algorithm, and relevant European guidelines were used to assess LDL‐C targets.
Results
Compared with LDL‐Cmh and LDL‐Cs, LDL‐Cf was able to correctly identify 96.9%‐98.08% of patients as within or outside the LDL‐C target, respectively, and 1.95%‐2.8% of patients were falsely identified as being within the LDL‐C target. Kappa coefficients for agreement between LDL‐Cf vs LDL‐Cmh and LDL‐Cf vs LDL‐Cs were 0.868 and 0.918 (P < .001). For patients not on cholesterol‐lowering drugs, the decision to initiate treatment would be different in 1.2%‐1.8% of cases if LDL‐Cs or LDL‐Cmh were used, respectively. For those already on cholesterol‐lowering drugs, decisions regarding treatment intensification would be different in 1.5%‐2.4% of cases if LDL‐Cs or LDL‐Cmh were used.
Conclusions
In most cardiology outpatients, the Friedewald equation has excellent agreement with the novel Martin/Hopkins and Sampson equations, and treatment decisions should not change in most patients.</description><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Low density lipoprotein</subject><subject>Patients</subject><subject>Triglycerides</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kctO3TAQhi3UCiiw4QEqS92gSgFf4sRhhyIoVCAqblvLsZ3Khxw72HHR2XXRB-AZeZL6cCgLFp3NjGY-_ZqZH4BdjPZxjgM7U-M-LlGD1sAmrktSYFLiD7mmFS8YongDfIpxhhBhjKN1sEEpqxGnbBP8uY2mT4MzMULfQ-d_mQFeyDBZd3Dqx3vrIpROw2s5H6N30DwkOVmfu5kM8CRYo82jHPTbBFoHlQza-sH_XECfpjH3jZviITyC7d11e3l1_Pz76eYKxtTFKenFNvjYyyGande8BW5Pjm_a0-L88ttZe3ReKNpQVBBSGU1It7yIdHXTKVZJpWuldFXWXU-o5kwZRBRWvENI1Y3G0pS66Tjvm4pugb2V7hj8QzJxEnMblRkG6YxPUZCSc8YwRSyjX96hM5-Cy9sJwgjPzyMv1NcVpYKPMZhejMHOZVgIjMTSG7H0Rrx4k-HPr5Kpmxv9hv4zIwN4BTzawSz-IyXOvrc_VqJ_Aedym5o</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Dinç Asarcıklı, Lale</creator><creator>Kış, Mehmet</creator><creator>Güvenç, Tolga Sinan</creator><creator>Tosun, Veysel</creator><creator>Acar, Burak</creator><creator>Avcı Demir, Fulya</creator><creator>Naser, Abdulrahman</creator><creator>Zoghi, Mehdi</creator><general>Hindawi Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7828-9487</orcidid></search><sort><creationdate>202106</creationdate><title>Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE‐TR substudy</title><author>Dinç Asarcıklı, Lale ; Kış, Mehmet ; Güvenç, Tolga Sinan ; Tosun, Veysel ; Acar, Burak ; Avcı Demir, Fulya ; Naser, Abdulrahman ; Zoghi, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3930-226ed22b50312b79bc56acd7ccd647bf23d85ce02c1c8b00c79d1ae4d9b88f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Low density lipoprotein</topic><topic>Patients</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dinç Asarcıklı, Lale</creatorcontrib><creatorcontrib>Kış, Mehmet</creatorcontrib><creatorcontrib>Güvenç, Tolga Sinan</creatorcontrib><creatorcontrib>Tosun, Veysel</creatorcontrib><creatorcontrib>Acar, Burak</creatorcontrib><creatorcontrib>Avcı Demir, Fulya</creatorcontrib><creatorcontrib>Naser, Abdulrahman</creatorcontrib><creatorcontrib>Zoghi, Mehdi</creatorcontrib><creatorcontrib>CVSCORE-TR investigators</creatorcontrib><creatorcontrib>CVSCORE‐TR investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dinç Asarcıklı, Lale</au><au>Kış, Mehmet</au><au>Güvenç, Tolga Sinan</au><au>Tosun, Veysel</au><au>Acar, Burak</au><au>Avcı Demir, Fulya</au><au>Naser, Abdulrahman</au><au>Zoghi, Mehdi</au><aucorp>CVSCORE-TR investigators</aucorp><aucorp>CVSCORE‐TR investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE‐TR substudy</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2021-06</date><risdate>2021</risdate><volume>75</volume><issue>6</issue><spage>e14090</spage><epage>n/a</epage><pages>e14090-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Background and aims
The Friedewald equation (LDL‐Cf) is known to produce inaccurate estimations of low‐density lipoprotein cholesterol (LDL‐C) when triglycerides are high (>400 mg/dL) or LDL‐C is low (<70 mg/dL). The Martin/Hopkins (LDL‐Cmh) and Sampson (LDL‐Cs) equations were developed to overcome these limitations, but few data are available to assess whether these equations offer incremental usefulness over LDL‐Cf. Our aim was to understand whether there was any incremental usefulness of novel equations on decisions regarding patient management.
Methods
Four thousand one hundred and ninety‐six cardiology patients who were included in a multicentre registry database were analysed. Each patient was assigned to a cardiovascular risk class using the SCORE (Systematic COronary Risk Evaluation) algorithm, and relevant European guidelines were used to assess LDL‐C targets.
Results
Compared with LDL‐Cmh and LDL‐Cs, LDL‐Cf was able to correctly identify 96.9%‐98.08% of patients as within or outside the LDL‐C target, respectively, and 1.95%‐2.8% of patients were falsely identified as being within the LDL‐C target. Kappa coefficients for agreement between LDL‐Cf vs LDL‐Cmh and LDL‐Cf vs LDL‐Cs were 0.868 and 0.918 (P < .001). For patients not on cholesterol‐lowering drugs, the decision to initiate treatment would be different in 1.2%‐1.8% of cases if LDL‐Cs or LDL‐Cmh were used, respectively. For those already on cholesterol‐lowering drugs, decisions regarding treatment intensification would be different in 1.5%‐2.4% of cases if LDL‐Cs or LDL‐Cmh were used.
Conclusions
In most cardiology outpatients, the Friedewald equation has excellent agreement with the novel Martin/Hopkins and Sampson equations, and treatment decisions should not change in most patients.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>33570835</pmid><doi>10.1111/ijcp.14090</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7828-9487</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cardiology Cardiovascular diseases Cholesterol Low density lipoprotein Patients Triglycerides |
| title | Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE‐TR substudy |
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