Histone deacetylase inhibitor chidamide regulates the Wnt/β-catenin pathway by MYCN/DKK3 in B-ALL

Summary Our previous studies revealed that MYCN downregulates the expression of DKK3 , activates the Wnt/β-catenin signalling pathway at the transcriptional level, and thereby promotes the development of B cell acute lymphocytic leukaemia (B-ALL) but does not affect the methylation of the DKK3 promo...

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Veröffentlicht in:	Investigational new drugs 2021-08, Vol.39 (4), p.961-970
Hauptverfasser:	Zhao, Linlin, Lv, Chengfang, Sun, Lili, Li, Qi, Wang, Yuhuang, Wu, Min, Wang, Yuying, Guo, Zhibo, Bian, Sicheng, Kong, Desheng, Lin, Leilei, Wang, Yu, Zhou, Jin, Li, Yinghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acute lymphoblastic leukemia Adaptor Proteins, Signal Transducing - genetics Aminopyridines - pharmacology Animals Apoptosis Benzamides - pharmacology Biotechnology Bone marrow Cell cycle Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy DNA methylation Experiments Gene Expression Regulation, Neoplastic - drug effects Hematology Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histones Humans Hypotheses Leukemia Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, SCID N-Myc Proto-Oncogene Protein - genetics Oncology Pharmacology/Toxicology Preclinical Studies Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proteins Signal transduction Signaling Transcription Wnt protein Wnt Signaling Pathway - drug effects Xenograft Model Antitumor Assays β-Catenin
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