Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells
Periodontitis is a widespread human chronic inflammatory disease of the tooth-surrounding tissues, which induces the destruction of periodontium and pathologic loss of teeth among adults. It has been reported that interleukin (IL)-17 was significantly increased in periodontitis patients compared to...
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| Veröffentlicht in: | Inflammation 2021-08, Vol.44 (4), p.1302-1314 |
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| creator | Zhang, Jiahao Dong, Xiaohong Yan, Qianqian Ren, Wei Zhang, Rui Jiang, Xinyi Geng, Zhaoli Xu, Xinyi Liu, Chunpeng Zhang, Shijie Liu, Dongxu Liu, Yi |
| description | Periodontitis is a widespread human chronic inflammatory disease of the tooth-surrounding tissues, which induces the destruction of periodontium and pathologic loss of teeth among adults. It has been reported that interleukin (IL)-17 was significantly increased in periodontitis patients compared to controls, while galectin-1 (Gal-1) was lower. Interestingly, it is found that Gal-1 treatment reduced systemic IL-17 levels. Hence, the aim of the present study was to explore the effect of Gal-1 on periodontitis development and investigate its underlying mechanism. In this study, Gal-1 was poorly expressed in lipopolysaccharide (LPS)-induced human periodontal ligament stem cells (hPDLSCs), and Gal-1 overexpression attenuated the production of inflammatory cytokines induced by LPS. Moreover, Gal-1 overexpression alleviated LPS-induced cell autophagy and apoptosis and reduced the expressions of IL-17A and IL-17R. Interestingly, IL-17A reversed the effect of Gal-1 on cell autophagy, inflammation, and cell apoptosis induced by the LPS challenge. In conclusion, Gal-1 inhibited LPS-induced autophagy and apoptosis of hPDLSC
via
regulation of IL-17A expression. Therefore, Gal-1 may have promising potential in regenerating periodontium. |
| doi_str_mv | 10.1007/s10753-021-01417-y |
| format | Article |
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via
regulation of IL-17A expression. Therefore, Gal-1 may have promising potential in regenerating periodontium.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-021-01417-y</identifier><identifier>PMID: 33566256</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Autophagy ; Autophagy - drug effects ; Autophagy - physiology ; Biomedical and Life Sciences ; Biomedicine ; Cells, Cultured ; Galectin 1 - biosynthesis ; Galectin-1 ; Humans ; Immunology ; Inflammatory diseases ; Interleukin 17 ; Internal Medicine ; Ligaments ; Lipopolysaccharides ; Lipopolysaccharides - toxicity ; Original Article ; Pathology ; Periodontal ligament ; Periodontal Ligament - drug effects ; Periodontal Ligament - metabolism ; Periodontal Ligament - pathology ; Periodontitis ; Periodontium ; Phagocytosis ; Pharmacology/Toxicology ; Rheumatology ; Stem cells ; Stem Cells - drug effects ; Stem Cells - metabolism ; Stem Cells - pathology</subject><ispartof>Inflammation, 2021-08, Vol.44 (4), p.1302-1314</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-59b91418b1c80119b85c1a70aaaf70a4813cf15eedd20f098b98b624131131ea3</citedby><cites>FETCH-LOGICAL-c441t-59b91418b1c80119b85c1a70aaaf70a4813cf15eedd20f098b98b624131131ea3</cites><orcidid>0000-0001-9490-1544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-021-01417-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-021-01417-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33566256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jiahao</creatorcontrib><creatorcontrib>Dong, Xiaohong</creatorcontrib><creatorcontrib>Yan, Qianqian</creatorcontrib><creatorcontrib>Ren, Wei</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Jiang, Xinyi</creatorcontrib><creatorcontrib>Geng, Zhaoli</creatorcontrib><creatorcontrib>Xu, Xinyi</creatorcontrib><creatorcontrib>Liu, Chunpeng</creatorcontrib><creatorcontrib>Zhang, Shijie</creatorcontrib><creatorcontrib>Liu, Dongxu</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><title>Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Periodontitis is a widespread human chronic inflammatory disease of the tooth-surrounding tissues, which induces the destruction of periodontium and pathologic loss of teeth among adults. It has been reported that interleukin (IL)-17 was significantly increased in periodontitis patients compared to controls, while galectin-1 (Gal-1) was lower. Interestingly, it is found that Gal-1 treatment reduced systemic IL-17 levels. Hence, the aim of the present study was to explore the effect of Gal-1 on periodontitis development and investigate its underlying mechanism. In this study, Gal-1 was poorly expressed in lipopolysaccharide (LPS)-induced human periodontal ligament stem cells (hPDLSCs), and Gal-1 overexpression attenuated the production of inflammatory cytokines induced by LPS. Moreover, Gal-1 overexpression alleviated LPS-induced cell autophagy and apoptosis and reduced the expressions of IL-17A and IL-17R. Interestingly, IL-17A reversed the effect of Gal-1 on cell autophagy, inflammation, and cell apoptosis induced by the LPS challenge. In conclusion, Gal-1 inhibited LPS-induced autophagy and apoptosis of hPDLSC
via
regulation of IL-17A expression. Therefore, Gal-1 may have promising potential in regenerating periodontium.</description><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Autophagy</subject><subject>Autophagy - drug effects</subject><subject>Autophagy - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cells, Cultured</subject><subject>Galectin 1 - biosynthesis</subject><subject>Galectin-1</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammatory diseases</subject><subject>Interleukin 17</subject><subject>Internal Medicine</subject><subject>Ligaments</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Periodontal ligament</subject><subject>Periodontal Ligament - drug effects</subject><subject>Periodontal Ligament - metabolism</subject><subject>Periodontal Ligament - pathology</subject><subject>Periodontitis</subject><subject>Periodontium</subject><subject>Phagocytosis</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><subject>Stem cells</subject><subject>Stem Cells - drug effects</subject><subject>Stem Cells - metabolism</subject><subject>Stem Cells - pathology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1PxCAQhonR6Lr6BzwYEi9eUAZKoUez8WOTTTRRz4S2dK1poRZ62H8vun4kHkwmMIRnXoZ5EToBegGUyssAVApOKANCIQNJNjtoBkJywoTMd9GM8pwSXhTyAB2G8EopVYXi--iAc5HnTOQzZG5NZ6vYOgJ46V7aso22xquHR7J09VSl_GqKfngx6w02Lp0GP0Qf2oB9g--m3jj8YMfW195F0-FVuza9dRE_Rtvjhe26cIT2GtMFe_y1z9HzzfXT4o6s7m-Xi6sVqbIMIhFFWaRPqBIqRQGKUokKjKTGmCatmQJeNSCsrWtGG1qoMkXOMuCQwho-R-db3WH0b5MNUfdtqFIHxlk_Bc0ypaCQIlcJPfuDvvppdKk7zYRgoLhMU5wjtqWq0Ycw2kYPY9ubcaOB6g8D9NYAnQzQnwboTSo6_ZKeyt7WPyXfE08A3wIhXbm1HX_f_kf2HXv_j50</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Zhang, Jiahao</creator><creator>Dong, Xiaohong</creator><creator>Yan, Qianqian</creator><creator>Ren, Wei</creator><creator>Zhang, Rui</creator><creator>Jiang, Xinyi</creator><creator>Geng, Zhaoli</creator><creator>Xu, Xinyi</creator><creator>Liu, Chunpeng</creator><creator>Zhang, Shijie</creator><creator>Liu, Dongxu</creator><creator>Liu, Yi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9490-1544</orcidid></search><sort><creationdate>20210801</creationdate><title>Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells</title><author>Zhang, Jiahao ; Dong, Xiaohong ; Yan, Qianqian ; Ren, Wei ; Zhang, Rui ; Jiang, Xinyi ; Geng, Zhaoli ; Xu, Xinyi ; Liu, Chunpeng ; Zhang, Shijie ; Liu, Dongxu ; Liu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-59b91418b1c80119b85c1a70aaaf70a4813cf15eedd20f098b98b624131131ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Autophagy</topic><topic>Autophagy - drug effects</topic><topic>Autophagy - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cells, Cultured</topic><topic>Galectin 1 - biosynthesis</topic><topic>Galectin-1</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammatory diseases</topic><topic>Interleukin 17</topic><topic>Internal Medicine</topic><topic>Ligaments</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Periodontal ligament</topic><topic>Periodontal Ligament - drug effects</topic><topic>Periodontal Ligament - metabolism</topic><topic>Periodontal Ligament - pathology</topic><topic>Periodontitis</topic><topic>Periodontium</topic><topic>Phagocytosis</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><topic>Stem cells</topic><topic>Stem Cells - drug effects</topic><topic>Stem Cells - metabolism</topic><topic>Stem Cells - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jiahao</creatorcontrib><creatorcontrib>Dong, Xiaohong</creatorcontrib><creatorcontrib>Yan, Qianqian</creatorcontrib><creatorcontrib>Ren, Wei</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Jiang, Xinyi</creatorcontrib><creatorcontrib>Geng, Zhaoli</creatorcontrib><creatorcontrib>Xu, Xinyi</creatorcontrib><creatorcontrib>Liu, Chunpeng</creatorcontrib><creatorcontrib>Zhang, Shijie</creatorcontrib><creatorcontrib>Liu, Dongxu</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jiahao</au><au>Dong, Xiaohong</au><au>Yan, Qianqian</au><au>Ren, Wei</au><au>Zhang, Rui</au><au>Jiang, Xinyi</au><au>Geng, Zhaoli</au><au>Xu, Xinyi</au><au>Liu, Chunpeng</au><au>Zhang, Shijie</au><au>Liu, Dongxu</au><au>Liu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>44</volume><issue>4</issue><spage>1302</spage><epage>1314</epage><pages>1302-1314</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Periodontitis is a widespread human chronic inflammatory disease of the tooth-surrounding tissues, which induces the destruction of periodontium and pathologic loss of teeth among adults. It has been reported that interleukin (IL)-17 was significantly increased in periodontitis patients compared to controls, while galectin-1 (Gal-1) was lower. Interestingly, it is found that Gal-1 treatment reduced systemic IL-17 levels. Hence, the aim of the present study was to explore the effect of Gal-1 on periodontitis development and investigate its underlying mechanism. In this study, Gal-1 was poorly expressed in lipopolysaccharide (LPS)-induced human periodontal ligament stem cells (hPDLSCs), and Gal-1 overexpression attenuated the production of inflammatory cytokines induced by LPS. Moreover, Gal-1 overexpression alleviated LPS-induced cell autophagy and apoptosis and reduced the expressions of IL-17A and IL-17R. Interestingly, IL-17A reversed the effect of Gal-1 on cell autophagy, inflammation, and cell apoptosis induced by the LPS challenge. In conclusion, Gal-1 inhibited LPS-induced autophagy and apoptosis of hPDLSC
via
regulation of IL-17A expression. Therefore, Gal-1 may have promising potential in regenerating periodontium.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33566256</pmid><doi>10.1007/s10753-021-01417-y</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-9490-1544</orcidid></addata></record> |
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| subjects | Apoptosis Apoptosis - drug effects Apoptosis - physiology Autophagy Autophagy - drug effects Autophagy - physiology Biomedical and Life Sciences Biomedicine Cells, Cultured Galectin 1 - biosynthesis Galectin-1 Humans Immunology Inflammatory diseases Interleukin 17 Internal Medicine Ligaments Lipopolysaccharides Lipopolysaccharides - toxicity Original Article Pathology Periodontal ligament Periodontal Ligament - drug effects Periodontal Ligament - metabolism Periodontal Ligament - pathology Periodontitis Periodontium Phagocytosis Pharmacology/Toxicology Rheumatology Stem cells Stem Cells - drug effects Stem Cells - metabolism Stem Cells - pathology |
| title | Galectin-1 Inhibited LPS-Induced Autophagy and Apoptosis of Human Periodontal Ligament Stem Cells |
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