Genetic predisposition to alcohol dependence: The combined role of polygenic risk to general psychopathology and to high alcohol consumption

•Polygenic risk score was computed for alcohol consumption (drinks per week).•PCA applied to nine psychiatric PRS to estimate the general psychopatology factor (polygenic p).•Both risk scores associated with alcohol dependence, contributing additively to risk.•The polygenic p remains associated in t...

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Veröffentlicht in:	Drug and alcohol dependence 2021-04, Vol.221, p.108556-108556, Article 108556
Hauptverfasser:	Facal, Fernando, Flórez, Gerardo, Blanco, Vanessa, Rodríguez, Julio, Pereiro, César, Fernández, José Manuel, Fariñas, Emilio, Estévez, Valentín, Gómez-Trigo, Jesús, Gurriarán, Xaquín, Sáiz, Pilar, Vázquez, Fernando Lino, Arrojo, Manuel, Costas, Javier, Osorio, Jesús, Carrera, Indalecio, Páramo, María José, López, Nicolás, García, Ana, González, Ana María, Rodríguez, Juana María, Matalobos, Manuela, Pomares, Joaquín, Longo, María Jesús, Álvarez, Sandra, Pino, Carlos, Martín, Carlos, Páramo, Mario, Paz, Eduardo, Serrano, Manuel, Miguel, Domingo, Crecente, Ana María López
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol use Alcohol use disorder Alcoholic beverages Alcoholism Alcohols Comorbidity Dependence Disorders Drinks Drug dependence General psychopathology factor Genetic diversity Genetic risk Genetic variance Mental disorders P factor Polygenic inheritance Principal components analysis Psychiatric comorbidity Psychopathology Risk management Sensitivity analysis Substance abuse Substance use Substance use disorders The p factor Variants
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