Qingda granule attenuates cardiac fibrosis via suppression of the TGF-β1/Smad2/3 signaling pathway in vitro and in vivo

[Display omitted] •QDG attenuates elevated blood pressure in SHRs.•QDG ameliorates cardiac fibrosis of SHRs and Ang II-induced CFs.•QDG inhibits the TGF-β1/Smad signaling pathway. Cardiac fibrosis plays an important role in hypertension-related contractile dysfunction and heart failure. Qingda granu...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-05, Vol.137, p.111318-111318, Article 111318
Hauptverfasser:	Chen, Xiaoping, Long, Linzi, Cheng, Ying, Chu, Jianfeng, Shen, Zhiqing, Liu, Liya, Li, Jiapeng, Xie, Qiurong, Liu, Huixin, Wu, Meizhu, Chen, Youqin, Peng, Jun, Shen, Aling
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac fibrosis Hypertension Qingda granule TGF-β1/Smad2/3
Online-Zugang:	Volltext
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