Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report
Paraneoplastic limbic encephalitis (PLE) is an immunopathologic syndrome associated with malignancy and represents a rare remote outcome of tumor on the nervous system. We report a case of PLE caused by a regressed testicular germ cell tumor in an otherwise healthy young man, who presented with acut...
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| Veröffentlicht in: | Clinical imaging 2021-08, Vol.76, p.61-64 |
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| creator | Chen, Christine Nadeem, Aqsa Karir, Beerinder Shohet, Hilary Hochberg Babagbemi, Kemi |
| description | Paraneoplastic limbic encephalitis (PLE) is an immunopathologic syndrome associated with malignancy and represents a rare remote outcome of tumor on the nervous system. We report a case of PLE caused by a regressed testicular germ cell tumor in an otherwise healthy young man, who presented with acute-onset confusion, memory impairment and anterograde amnesia. Prompt recognition of PLE is critical as it allows early treatment of both the primary tumor and PLE-related neurologic impairments, which can be severe and irreversible if treatment is delayed. Complete tumor treatment response offers the best chance for neurologic recovery in patients with PLE. To our knowledge, this is the second reported case of PLE with radiologic-pathologic correlation in the setting of a regressed testicular germ cell tumor.
•PLE associated with regressed testicular germ cell tumor is exceedingly rare.•Anti-Ma2/Ta antibody is a paraneoplastic antibody associated with testicular tumors in men less than 50 years of age.•Early recognition of PLE allows early diagnosis and treatment of the primary tumor. |
| doi_str_mv | 10.1016/j.clinimag.2021.01.032 |
| format | Article |
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•PLE associated with regressed testicular germ cell tumor is exceedingly rare.•Anti-Ma2/Ta antibody is a paraneoplastic antibody associated with testicular tumors in men less than 50 years of age.•Early recognition of PLE allows early diagnosis and treatment of the primary tumor.</description><identifier>ISSN: 0899-7071</identifier><identifier>EISSN: 1873-4499</identifier><identifier>DOI: 10.1016/j.clinimag.2021.01.032</identifier><identifier>PMID: 33556762</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amnesia ; Antibodies ; Antigens ; Biomarkers ; Breast cancer ; Case reports ; Cognitive ability ; Encephalitis ; Limbic ; Magnetic resonance imaging ; Malignancy ; Memory ; Nervous system ; Paraneoplastic ; Patients ; Regressed ; Testes ; Testicular cancer ; Testis ; Tumor ; Tumors</subject><ispartof>Clinical imaging, 2021-08, Vol.76, p.61-64</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-ab0e0df7cbb6c9f2d514d75a315774c7867c4d2b341fc1996c9ccd03528640283</citedby><cites>FETCH-LOGICAL-c396t-ab0e0df7cbb6c9f2d514d75a315774c7867c4d2b341fc1996c9ccd03528640283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinimag.2021.01.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33556762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Christine</creatorcontrib><creatorcontrib>Nadeem, Aqsa</creatorcontrib><creatorcontrib>Karir, Beerinder</creatorcontrib><creatorcontrib>Shohet, Hilary Hochberg</creatorcontrib><creatorcontrib>Babagbemi, Kemi</creatorcontrib><title>Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report</title><title>Clinical imaging</title><addtitle>Clin Imaging</addtitle><description>Paraneoplastic limbic encephalitis (PLE) is an immunopathologic syndrome associated with malignancy and represents a rare remote outcome of tumor on the nervous system. We report a case of PLE caused by a regressed testicular germ cell tumor in an otherwise healthy young man, who presented with acute-onset confusion, memory impairment and anterograde amnesia. Prompt recognition of PLE is critical as it allows early treatment of both the primary tumor and PLE-related neurologic impairments, which can be severe and irreversible if treatment is delayed. Complete tumor treatment response offers the best chance for neurologic recovery in patients with PLE. To our knowledge, this is the second reported case of PLE with radiologic-pathologic correlation in the setting of a regressed testicular germ cell tumor.
•PLE associated with regressed testicular germ cell tumor is exceedingly rare.•Anti-Ma2/Ta antibody is a paraneoplastic antibody associated with testicular tumors in men less than 50 years of age.•Early recognition of PLE allows early diagnosis and treatment of the primary tumor.</description><subject>Amnesia</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Case reports</subject><subject>Cognitive ability</subject><subject>Encephalitis</subject><subject>Limbic</subject><subject>Magnetic resonance imaging</subject><subject>Malignancy</subject><subject>Memory</subject><subject>Nervous system</subject><subject>Paraneoplastic</subject><subject>Patients</subject><subject>Regressed</subject><subject>Testes</subject><subject>Testicular cancer</subject><subject>Testis</subject><subject>Tumor</subject><subject>Tumors</subject><issn>0899-7071</issn><issn>1873-4499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkUlLBDEQhYMoOi5_QQJevPSYrZOOJ0XcQNCDnmM6ndYM6cUkLfjvTTOjBy9CQV2-96rqFQDHGC0xwvxstTTe9a7Tb0uCCF6iXJRsgQWuBC0Yk3IbLFAlZSGQwHtgP8YVykLJxC7Yo7QsueBkAV6fdNC9HUavY3IGetfVudne2PFde5dchDrCPCo57eEYbLR90skNPRxamOysmrwOcGPSncNLaHS0MNhxCOkQ7LTaR3u06Qfg5eb6-equeHi8vb-6fCgMlTwVukYWNa0wdc2NbElTYtaIUlNcCsGMqLgwrCE1Zbg1WMoMGdMgWpKKM0QqegBO175jGD6mvJbqXDTW-_m6KSrCqmzEEaMZPfmDroYp9Hk7RUqW4-IVxZnia8qEIcZgWzWGnHf4Uhip-QdqpX5-oOYfKJSLkiw83thPdWebX9lP6Bm4WAM25_HpbFDRuDnxxgVrkmoG99-MbyeNm7E</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Chen, Christine</creator><creator>Nadeem, Aqsa</creator><creator>Karir, Beerinder</creator><creator>Shohet, Hilary Hochberg</creator><creator>Babagbemi, Kemi</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report</title><author>Chen, Christine ; Nadeem, Aqsa ; Karir, Beerinder ; Shohet, Hilary Hochberg ; Babagbemi, Kemi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-ab0e0df7cbb6c9f2d514d75a315774c7867c4d2b341fc1996c9ccd03528640283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amnesia</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Case reports</topic><topic>Cognitive ability</topic><topic>Encephalitis</topic><topic>Limbic</topic><topic>Magnetic resonance imaging</topic><topic>Malignancy</topic><topic>Memory</topic><topic>Nervous system</topic><topic>Paraneoplastic</topic><topic>Patients</topic><topic>Regressed</topic><topic>Testes</topic><topic>Testicular cancer</topic><topic>Testis</topic><topic>Tumor</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Christine</creatorcontrib><creatorcontrib>Nadeem, Aqsa</creatorcontrib><creatorcontrib>Karir, Beerinder</creatorcontrib><creatorcontrib>Shohet, Hilary Hochberg</creatorcontrib><creatorcontrib>Babagbemi, Kemi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Christine</au><au>Nadeem, Aqsa</au><au>Karir, Beerinder</au><au>Shohet, Hilary Hochberg</au><au>Babagbemi, Kemi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report</atitle><jtitle>Clinical imaging</jtitle><addtitle>Clin Imaging</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>76</volume><spage>61</spage><epage>64</epage><pages>61-64</pages><issn>0899-7071</issn><eissn>1873-4499</eissn><abstract>Paraneoplastic limbic encephalitis (PLE) is an immunopathologic syndrome associated with malignancy and represents a rare remote outcome of tumor on the nervous system. We report a case of PLE caused by a regressed testicular germ cell tumor in an otherwise healthy young man, who presented with acute-onset confusion, memory impairment and anterograde amnesia. Prompt recognition of PLE is critical as it allows early treatment of both the primary tumor and PLE-related neurologic impairments, which can be severe and irreversible if treatment is delayed. Complete tumor treatment response offers the best chance for neurologic recovery in patients with PLE. To our knowledge, this is the second reported case of PLE with radiologic-pathologic correlation in the setting of a regressed testicular germ cell tumor.
•PLE associated with regressed testicular germ cell tumor is exceedingly rare.•Anti-Ma2/Ta antibody is a paraneoplastic antibody associated with testicular tumors in men less than 50 years of age.•Early recognition of PLE allows early diagnosis and treatment of the primary tumor.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33556762</pmid><doi>10.1016/j.clinimag.2021.01.032</doi><tpages>4</tpages></addata></record> |
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| subjects | Amnesia Antibodies Antigens Biomarkers Breast cancer Case reports Cognitive ability Encephalitis Limbic Magnetic resonance imaging Malignancy Memory Nervous system Paraneoplastic Patients Regressed Testes Testicular cancer Testis Tumor Tumors |
| title | Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report |
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