Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age

Abstract Repeated infections with endemic human coronaviruses (hCoV) are thought to reflect lack of long-lasting protective immunity. We evaluated circulating human CD4 T cells collected prior to 2020 for reactivity towards hCoV spike proteins, probing for the ability to produce interferon-γ, interl...

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Veröffentlicht in:	The Journal of infectious diseases 2021-05, Vol.223 (9), p.1555-1563
Hauptverfasser:	Richards, Katherine A, Glover, Maryah, Crawford, Jeremy C, Thomas, Paul G, White, Chantelle, Sant, Andrea J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens CD4 antigen Coronaviruses Epitopes Granzyme B Immunological memory Influenza Interleukin 2 Lymphocytes Lymphocytes T Memory cells Nucleocapsids Severe acute respiratory syndrome coronavirus 2 γ-Interferon
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