Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis
•30 papers included providing information on the relationship between fatigue and health outcomes.•Fatigue increases the risk for developing negative health outcomes (OR 1.3–3.1 HR/RR 1.0–1.5).•Fatigue-related physical decline occurs earlier than hospitalization, disease & mortality. Fatigue is...
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| Veröffentlicht in: | Ageing research reviews 2021-05, Vol.67, p.101261-101261, Article 101261 |
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| creator | Knoop, V. Cloots, B. Costenoble, A. Debain, A. Vella Azzopardi, R. Vermeiren, S. Jansen, B. Scafoglieri, A. Bautmans, I. Bautmans, Ivan Verté, Dominque Beyer, Ingo Petrovic, Mirko De Donder, Liesbeth Kardol, Tinie Rossi, Gina Clarys, Peter Scafoglieri, Aldo Cattrysse, Erik de Hert, Paul Jansen, Bart |
| description | •30 papers included providing information on the relationship between fatigue and health outcomes.•Fatigue increases the risk for developing negative health outcomes (OR 1.3–3.1 HR/RR 1.0–1.5).•Fatigue-related physical decline occurs earlier than hospitalization, disease & mortality.
Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults.
PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high).
In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711 participants (age range 40–98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1.299–3.094; HR/RR 1.038–1.471); for example, mortality OR 2.14 [1.74–2.63]; HR/RR 1.44 [1.28–1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05–5.38]), or the occurrence of physical decline (OR 1.42 [1.29–1.57]).
Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions. |
| doi_str_mv | 10.1016/j.arr.2021.101261 |
| format | Article |
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Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults.
PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high).
In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711 participants (age range 40–98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1.299–3.094; HR/RR 1.038–1.471); for example, mortality OR 2.14 [1.74–2.63]; HR/RR 1.44 [1.28–1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05–5.38]), or the occurrence of physical decline (OR 1.42 [1.29–1.57]).
Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions.</description><identifier>ISSN: 1568-1637</identifier><identifier>EISSN: 1872-9649</identifier><identifier>DOI: 10.1016/j.arr.2021.101261</identifier><identifier>PMID: 33548508</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Activities of Daily Living ; Aged ; Aged, 80 and over ; Community-Dwelling ; Elderly ; Fatigue ; Fatigue - epidemiology ; Female ; Humans ; Independent Living ; Male ; Meta-Analysis ; Prospective risk outcomes ; Prospective Studies ; Tiredness</subject><ispartof>Ageing research reviews, 2021-05, Vol.67, p.101261-101261, Article 101261</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-4ad0dc0abed13d7344481cce55100da53d5beb1a00657298c6a4131c6a85f6e63</citedby><cites>FETCH-LOGICAL-c396t-4ad0dc0abed13d7344481cce55100da53d5beb1a00657298c6a4131c6a85f6e63</cites><orcidid>0000-0002-6820-9586 ; 0000-0002-1793-6476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1568163721000088$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33548508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knoop, V.</creatorcontrib><creatorcontrib>Cloots, B.</creatorcontrib><creatorcontrib>Costenoble, A.</creatorcontrib><creatorcontrib>Debain, A.</creatorcontrib><creatorcontrib>Vella Azzopardi, R.</creatorcontrib><creatorcontrib>Vermeiren, S.</creatorcontrib><creatorcontrib>Jansen, B.</creatorcontrib><creatorcontrib>Scafoglieri, A.</creatorcontrib><creatorcontrib>Bautmans, I.</creatorcontrib><creatorcontrib>Bautmans, Ivan</creatorcontrib><creatorcontrib>Verté, Dominque</creatorcontrib><creatorcontrib>Beyer, Ingo</creatorcontrib><creatorcontrib>Petrovic, Mirko</creatorcontrib><creatorcontrib>De Donder, Liesbeth</creatorcontrib><creatorcontrib>Kardol, Tinie</creatorcontrib><creatorcontrib>Rossi, Gina</creatorcontrib><creatorcontrib>Clarys, Peter</creatorcontrib><creatorcontrib>Scafoglieri, Aldo</creatorcontrib><creatorcontrib>Cattrysse, Erik</creatorcontrib><creatorcontrib>de Hert, Paul</creatorcontrib><creatorcontrib>Jansen, Bart</creatorcontrib><creatorcontrib>on behalf of the Gerontopole Brussels Study group</creatorcontrib><creatorcontrib>Gerontopole Brussels Study group</creatorcontrib><title>Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis</title><title>Ageing research reviews</title><addtitle>Ageing Res Rev</addtitle><description>•30 papers included providing information on the relationship between fatigue and health outcomes.•Fatigue increases the risk for developing negative health outcomes (OR 1.3–3.1 HR/RR 1.0–1.5).•Fatigue-related physical decline occurs earlier than hospitalization, disease & mortality.
Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults.
PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high).
In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711 participants (age range 40–98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1.299–3.094; HR/RR 1.038–1.471); for example, mortality OR 2.14 [1.74–2.63]; HR/RR 1.44 [1.28–1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05–5.38]), or the occurrence of physical decline (OR 1.42 [1.29–1.57]).
Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions.</description><subject>Activities of Daily Living</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Community-Dwelling</subject><subject>Elderly</subject><subject>Fatigue</subject><subject>Fatigue - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Independent Living</subject><subject>Male</subject><subject>Meta-Analysis</subject><subject>Prospective risk outcomes</subject><subject>Prospective Studies</subject><subject>Tiredness</subject><issn>1568-1637</issn><issn>1872-9649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAURS0EYih8ABvkJZsUOx6SwApVTFIlNrDFcu0X6ipDsR2q_j2uUliyerbeuVd6B6FLSqaUUHmzmmrvpznJ6e6fS3qATmlZ5FkleXWY3kKWGZWsOEFnIaxIylQyP0YnjAleClKeoo9HHd3nAFh3Fscl4LUH60x0fYf7GnfwmfbfgJegm7jE_RBN30K4xfc4bEOENq0N9vDtYIM3LiEtRJ3pTjfb4MI5Oqp1E-BiPyfo_fHhbfaczV-fXmb388ywSsaMa0usIXoBljJbMM55SY0BISghVgtmxQIWVBMiRZFXpZGaU0bTKEUtQbIJuh57177_GiBE1bpgoGl0B_0QVM7LgjNBhUgoHVHj-xA81GrtXav9VlGidlrVSiWtaqdVjVpT5mpfPyxasH-JX48JuBsBSEcmF14F46AzyaUHE5Xt3T_1P5iOiJc</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Knoop, V.</creator><creator>Cloots, B.</creator><creator>Costenoble, A.</creator><creator>Debain, A.</creator><creator>Vella Azzopardi, R.</creator><creator>Vermeiren, S.</creator><creator>Jansen, B.</creator><creator>Scafoglieri, A.</creator><creator>Bautmans, I.</creator><creator>Bautmans, Ivan</creator><creator>Verté, Dominque</creator><creator>Beyer, Ingo</creator><creator>Petrovic, Mirko</creator><creator>De Donder, Liesbeth</creator><creator>Kardol, Tinie</creator><creator>Rossi, Gina</creator><creator>Clarys, Peter</creator><creator>Scafoglieri, Aldo</creator><creator>Cattrysse, Erik</creator><creator>de Hert, Paul</creator><creator>Jansen, Bart</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6820-9586</orcidid><orcidid>https://orcid.org/0000-0002-1793-6476</orcidid></search><sort><creationdate>202105</creationdate><title>Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis</title><author>Knoop, V. ; Cloots, B. ; Costenoble, A. ; Debain, A. ; Vella Azzopardi, R. ; Vermeiren, S. ; Jansen, B. ; Scafoglieri, A. ; Bautmans, I. ; Bautmans, Ivan ; Verté, Dominque ; Beyer, Ingo ; Petrovic, Mirko ; De Donder, Liesbeth ; Kardol, Tinie ; Rossi, Gina ; Clarys, Peter ; Scafoglieri, Aldo ; Cattrysse, Erik ; de Hert, Paul ; Jansen, Bart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-4ad0dc0abed13d7344481cce55100da53d5beb1a00657298c6a4131c6a85f6e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Activities of Daily Living</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Community-Dwelling</topic><topic>Elderly</topic><topic>Fatigue</topic><topic>Fatigue - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Independent Living</topic><topic>Male</topic><topic>Meta-Analysis</topic><topic>Prospective risk outcomes</topic><topic>Prospective Studies</topic><topic>Tiredness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knoop, V.</creatorcontrib><creatorcontrib>Cloots, B.</creatorcontrib><creatorcontrib>Costenoble, A.</creatorcontrib><creatorcontrib>Debain, A.</creatorcontrib><creatorcontrib>Vella Azzopardi, R.</creatorcontrib><creatorcontrib>Vermeiren, S.</creatorcontrib><creatorcontrib>Jansen, B.</creatorcontrib><creatorcontrib>Scafoglieri, A.</creatorcontrib><creatorcontrib>Bautmans, I.</creatorcontrib><creatorcontrib>Bautmans, Ivan</creatorcontrib><creatorcontrib>Verté, Dominque</creatorcontrib><creatorcontrib>Beyer, Ingo</creatorcontrib><creatorcontrib>Petrovic, Mirko</creatorcontrib><creatorcontrib>De Donder, Liesbeth</creatorcontrib><creatorcontrib>Kardol, Tinie</creatorcontrib><creatorcontrib>Rossi, Gina</creatorcontrib><creatorcontrib>Clarys, Peter</creatorcontrib><creatorcontrib>Scafoglieri, Aldo</creatorcontrib><creatorcontrib>Cattrysse, Erik</creatorcontrib><creatorcontrib>de Hert, Paul</creatorcontrib><creatorcontrib>Jansen, Bart</creatorcontrib><creatorcontrib>on behalf of the Gerontopole Brussels Study group</creatorcontrib><creatorcontrib>Gerontopole Brussels Study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ageing research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knoop, V.</au><au>Cloots, B.</au><au>Costenoble, A.</au><au>Debain, A.</au><au>Vella Azzopardi, R.</au><au>Vermeiren, S.</au><au>Jansen, B.</au><au>Scafoglieri, A.</au><au>Bautmans, I.</au><au>Bautmans, Ivan</au><au>Verté, Dominque</au><au>Beyer, Ingo</au><au>Petrovic, Mirko</au><au>De Donder, Liesbeth</au><au>Kardol, Tinie</au><au>Rossi, Gina</au><au>Clarys, Peter</au><au>Scafoglieri, Aldo</au><au>Cattrysse, Erik</au><au>de Hert, Paul</au><au>Jansen, Bart</au><aucorp>on behalf of the Gerontopole Brussels Study group</aucorp><aucorp>Gerontopole Brussels Study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis</atitle><jtitle>Ageing research reviews</jtitle><addtitle>Ageing Res Rev</addtitle><date>2021-05</date><risdate>2021</risdate><volume>67</volume><spage>101261</spage><epage>101261</epage><pages>101261-101261</pages><artnum>101261</artnum><issn>1568-1637</issn><eissn>1872-9649</eissn><abstract>•30 papers included providing information on the relationship between fatigue and health outcomes.•Fatigue increases the risk for developing negative health outcomes (OR 1.3–3.1 HR/RR 1.0–1.5).•Fatigue-related physical decline occurs earlier than hospitalization, disease & mortality.
Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults.
PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high).
In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711 participants (age range 40–98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1.299–3.094; HR/RR 1.038–1.471); for example, mortality OR 2.14 [1.74–2.63]; HR/RR 1.44 [1.28–1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05–5.38]), or the occurrence of physical decline (OR 1.42 [1.29–1.57]).
Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>33548508</pmid><doi>10.1016/j.arr.2021.101261</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6820-9586</orcidid><orcidid>https://orcid.org/0000-0002-1793-6476</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Activities of Daily Living Aged Aged, 80 and over Community-Dwelling Elderly Fatigue Fatigue - epidemiology Female Humans Independent Living Male Meta-Analysis Prospective risk outcomes Prospective Studies Tiredness |
| title | Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis |
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