Target separation and antitumor metastasis activity of sesquiterpene-based lysine-specific demethylase 1 inhibitors from zedoary turmeric oil

[Display omitted] •We established a target separation counter-current chromatography technique.•The technique was used to separate components of zedoary turmeric oil.•Four lysine-specific demethylase 1 (LSD1) inhibitors were efficiently separated.•These are the first sesquiterpene-based natural LSD1...

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Veröffentlicht in:	Bioorganic chemistry 2021-03, Vol.108, p.104666-104666, Article 104666
Hauptverfasser:	Ren, Chunling, Lin, Yaolan, Liu, Xiaoqin, Yan, Dan, Xu, Xiao, Zhu, Dongrong, Kong, Lingyi, Han, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Countercurrent chromatography Lysine-specific histone demethylase 1 inhibitor Sesquiterpene Tumor metastasis Zedoary turmeric oil
Online-Zugang:	Volltext
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