Epidemiology of Acute Gastroenteritis Caused by Rotavirus among Children Less than Five Years Old Admitted in Hospital, in North India
Objectives To report the data of burden of rotaviral acute gastroenteritis in under-five children from two states post-introduction of the vaccine. Methods Children under 5 y of age hospitalized with diarrhea from the states of Haryana and Himachal Pradesh in north India were recruited in the study....
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| Veröffentlicht in: | Indian journal of pediatrics 2021-03, Vol.88 (Suppl 1), p.22-27 |
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| container_title | Indian journal of pediatrics |
| container_volume | 88 |
| creator | Gupta, Madhu Bansal, Arun Bansal, Adarsh Aloona, Shivani Rana, Monica Muralidharan, Jayashree Kanojia, Ravi P. Sodhi, Kushaljit Singh Saxena, Akshaya Singh, Mini P. Bharti, Bhavneet Nair, Nayana P. Thiyagarajan, Varunkumar |
| description | Objectives
To report the data of burden of rotaviral acute gastroenteritis in under-five children from two states post-introduction of the vaccine.
Methods
Children under 5 y of age hospitalized with diarrhea from the states of Haryana and Himachal Pradesh in north India were recruited in the study. Commercially available ELISA kits were used for testing rotavirus in the collected stool samples. Genotyping of the positive samples was done by reverse-transcription polymerase chain reaction.
Results
Out of 345 samples collected, 69 (20%) were found to be positive for rotavirus by ELISA. Genotyping was done and G3P[8] (31.3%), G1P[8] (13.4%), G2P[4] (13.4%) were found to be prevalent strains. Mixed strains were also found in 19.4% stool samples.
Conclusions
The study highlighted the high burden of rotavirus associated diarrhea in north Indian states. The data is helpful for evaluating the impact of vaccine on the severity of acute gastroenteritis and the changing strains after the introduction of rotavirus vaccine in the Universal Immunization Program. |
| doi_str_mv | 10.1007/s12098-020-03619-y |
| format | Article |
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To report the data of burden of rotaviral acute gastroenteritis in under-five children from two states post-introduction of the vaccine.
Methods
Children under 5 y of age hospitalized with diarrhea from the states of Haryana and Himachal Pradesh in north India were recruited in the study. Commercially available ELISA kits were used for testing rotavirus in the collected stool samples. Genotyping of the positive samples was done by reverse-transcription polymerase chain reaction.
Results
Out of 345 samples collected, 69 (20%) were found to be positive for rotavirus by ELISA. Genotyping was done and G3P[8] (31.3%), G1P[8] (13.4%), G2P[4] (13.4%) were found to be prevalent strains. Mixed strains were also found in 19.4% stool samples.
Conclusions
The study highlighted the high burden of rotavirus associated diarrhea in north Indian states. The data is helpful for evaluating the impact of vaccine on the severity of acute gastroenteritis and the changing strains after the introduction of rotavirus vaccine in the Universal Immunization Program.</description><identifier>ISSN: 0019-5456</identifier><identifier>EISSN: 0973-7693</identifier><identifier>DOI: 10.1007/s12098-020-03619-y</identifier><identifier>PMID: 33555567</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Gynecology ; Medicine ; Medicine & Public Health ; Original Article ; Pediatrics</subject><ispartof>Indian journal of pediatrics, 2021-03, Vol.88 (Suppl 1), p.22-27</ispartof><rights>Dr. K C Chaudhuri Foundation 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-d94db481ebb7336839727fd8dd498f30b51c59dfc576d74d7f430a21e5c154bc3</citedby><cites>FETCH-LOGICAL-c347t-d94db481ebb7336839727fd8dd498f30b51c59dfc576d74d7f430a21e5c154bc3</cites><orcidid>0000-0003-3877-9956</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12098-020-03619-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12098-020-03619-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33555567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Madhu</creatorcontrib><creatorcontrib>Bansal, Arun</creatorcontrib><creatorcontrib>Bansal, Adarsh</creatorcontrib><creatorcontrib>Aloona, Shivani</creatorcontrib><creatorcontrib>Rana, Monica</creatorcontrib><creatorcontrib>Muralidharan, Jayashree</creatorcontrib><creatorcontrib>Kanojia, Ravi P.</creatorcontrib><creatorcontrib>Sodhi, Kushaljit Singh</creatorcontrib><creatorcontrib>Saxena, Akshaya</creatorcontrib><creatorcontrib>Singh, Mini P.</creatorcontrib><creatorcontrib>Bharti, Bhavneet</creatorcontrib><creatorcontrib>Nair, Nayana P.</creatorcontrib><creatorcontrib>Thiyagarajan, Varunkumar</creatorcontrib><title>Epidemiology of Acute Gastroenteritis Caused by Rotavirus among Children Less than Five Years Old Admitted in Hospital, in North India</title><title>Indian journal of pediatrics</title><addtitle>Indian J Pediatr</addtitle><addtitle>Indian J Pediatr</addtitle><description>Objectives
To report the data of burden of rotaviral acute gastroenteritis in under-five children from two states post-introduction of the vaccine.
Methods
Children under 5 y of age hospitalized with diarrhea from the states of Haryana and Himachal Pradesh in north India were recruited in the study. Commercially available ELISA kits were used for testing rotavirus in the collected stool samples. Genotyping of the positive samples was done by reverse-transcription polymerase chain reaction.
Results
Out of 345 samples collected, 69 (20%) were found to be positive for rotavirus by ELISA. Genotyping was done and G3P[8] (31.3%), G1P[8] (13.4%), G2P[4] (13.4%) were found to be prevalent strains. Mixed strains were also found in 19.4% stool samples.
Conclusions
The study highlighted the high burden of rotavirus associated diarrhea in north Indian states. The data is helpful for evaluating the impact of vaccine on the severity of acute gastroenteritis and the changing strains after the introduction of rotavirus vaccine in the Universal Immunization Program.</description><subject>Gynecology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pediatrics</subject><issn>0019-5456</issn><issn>0973-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM9u1DAQxi0EoqXwAhyQjxwI2LEdx8fVqv-kFZUQHDhZTjzZdZXEi8eplBfoc-OyhSO-jGfm-z5pfoS85-wzZ0x_QV4z01asZhUTDTfV-oKcM6NFpRsjXpY_K0MlVXNG3iDeM1Yb1pjX5EwIVV6jz8nj5TF4mEIc436lcaCbfslArx3mFGHOkEIOSLduQfC0W-m3mN1DSAtSN8V5T7eHMPoEM90BIs0HN9Or8AD0J7iE9G70dOOnkHNxh5neRDyG7MZPT83XmPKB3s4-uLfk1eBGhHfP9YL8uLr8vr2pdnfXt9vNruqF1LnyRvpOthy6TgvRtMLoWg--9V6adhCsU7xXxg-90o3X0utBCuZqDqrnSna9uCAfT7nHFH8tgNlOAXsYRzdDXNDWstWyNkrKIq1P0j5FxASDPaYwubRazuwTf3vibwt_-4e_XYvpw3P-0k3g_1n-Ai8CcRJgWc17SPY-LmkuN_8v9jeGoZJ2</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Gupta, Madhu</creator><creator>Bansal, Arun</creator><creator>Bansal, Adarsh</creator><creator>Aloona, Shivani</creator><creator>Rana, Monica</creator><creator>Muralidharan, Jayashree</creator><creator>Kanojia, Ravi P.</creator><creator>Sodhi, Kushaljit Singh</creator><creator>Saxena, Akshaya</creator><creator>Singh, Mini P.</creator><creator>Bharti, Bhavneet</creator><creator>Nair, Nayana P.</creator><creator>Thiyagarajan, Varunkumar</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3877-9956</orcidid></search><sort><creationdate>20210301</creationdate><title>Epidemiology of Acute Gastroenteritis Caused by Rotavirus among Children Less than Five Years Old Admitted in Hospital, in North India</title><author>Gupta, Madhu ; Bansal, Arun ; Bansal, Adarsh ; Aloona, Shivani ; Rana, Monica ; Muralidharan, Jayashree ; Kanojia, Ravi P. ; Sodhi, Kushaljit Singh ; Saxena, Akshaya ; Singh, Mini P. ; Bharti, Bhavneet ; Nair, Nayana P. ; Thiyagarajan, Varunkumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-d94db481ebb7336839727fd8dd498f30b51c59dfc576d74d7f430a21e5c154bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Gynecology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Madhu</creatorcontrib><creatorcontrib>Bansal, Arun</creatorcontrib><creatorcontrib>Bansal, Adarsh</creatorcontrib><creatorcontrib>Aloona, Shivani</creatorcontrib><creatorcontrib>Rana, Monica</creatorcontrib><creatorcontrib>Muralidharan, Jayashree</creatorcontrib><creatorcontrib>Kanojia, Ravi P.</creatorcontrib><creatorcontrib>Sodhi, Kushaljit Singh</creatorcontrib><creatorcontrib>Saxena, Akshaya</creatorcontrib><creatorcontrib>Singh, Mini P.</creatorcontrib><creatorcontrib>Bharti, Bhavneet</creatorcontrib><creatorcontrib>Nair, Nayana P.</creatorcontrib><creatorcontrib>Thiyagarajan, Varunkumar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Madhu</au><au>Bansal, Arun</au><au>Bansal, Adarsh</au><au>Aloona, Shivani</au><au>Rana, Monica</au><au>Muralidharan, Jayashree</au><au>Kanojia, Ravi P.</au><au>Sodhi, Kushaljit Singh</au><au>Saxena, Akshaya</au><au>Singh, Mini P.</au><au>Bharti, Bhavneet</au><au>Nair, Nayana P.</au><au>Thiyagarajan, Varunkumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of Acute Gastroenteritis Caused by Rotavirus among Children Less than Five Years Old Admitted in Hospital, in North India</atitle><jtitle>Indian journal of pediatrics</jtitle><stitle>Indian J Pediatr</stitle><addtitle>Indian J Pediatr</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>88</volume><issue>Suppl 1</issue><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>0019-5456</issn><eissn>0973-7693</eissn><abstract>Objectives
To report the data of burden of rotaviral acute gastroenteritis in under-five children from two states post-introduction of the vaccine.
Methods
Children under 5 y of age hospitalized with diarrhea from the states of Haryana and Himachal Pradesh in north India were recruited in the study. Commercially available ELISA kits were used for testing rotavirus in the collected stool samples. Genotyping of the positive samples was done by reverse-transcription polymerase chain reaction.
Results
Out of 345 samples collected, 69 (20%) were found to be positive for rotavirus by ELISA. Genotyping was done and G3P[8] (31.3%), G1P[8] (13.4%), G2P[4] (13.4%) were found to be prevalent strains. Mixed strains were also found in 19.4% stool samples.
Conclusions
The study highlighted the high burden of rotavirus associated diarrhea in north Indian states. The data is helpful for evaluating the impact of vaccine on the severity of acute gastroenteritis and the changing strains after the introduction of rotavirus vaccine in the Universal Immunization Program.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>33555567</pmid><doi>10.1007/s12098-020-03619-y</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3877-9956</orcidid></addata></record> |
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| subjects | Gynecology Medicine Medicine & Public Health Original Article Pediatrics |
| title | Epidemiology of Acute Gastroenteritis Caused by Rotavirus among Children Less than Five Years Old Admitted in Hospital, in North India |
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