Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer
Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the regulation of the immune system and potentially the progression of cervical neoplastic lesions. In this study, we aimed to explore the possible relationship between polymorphisms of the TNF-α gene and susceptibility t...
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| Veröffentlicht in: | Molecular biology reports 2021-02, Vol.48 (2), p.1433-1437 |
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| creator | Behboodi, Negin Farazestanian, Marjaneh Rastgar-Moghadam, Azam Mehramiz, Mehrane Karimi, Ehsan Rajabian, Majid Rahmani, Farzad Khorrami, Shadi Jafarian, Amirhosein Sharifi-Sistani, Noorieh Ferns, Gordon A. Avan, Amir Hasanzadeh, Malihe |
| description | Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the regulation of the immune system and potentially the progression of cervical neoplastic lesions. In this study, we aimed to explore the possible relationship between polymorphisms of the TNF-α gene and susceptibility to cervical cancer. The relationship between a single nucleotide polymorphism (SNP) in the TNF-α gene (rs1800629) and the risk of cervical cancer was evaluated in a total of 445 subjects with (n = 153), or without (n = 292) cancer. Genotyping was performed using a Taq-Man based real time PCR method. Logistic regression analysis showed that individuals with AG/AA genotypes had an increased risk of cervical cancer compared to those with a GG genotype (OR 3.79, 95% CI 2.4–5.7, |
| doi_str_mv | 10.1007/s11033-021-06185-4 |
| format | Article |
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In this study, we aimed to explore the possible relationship between polymorphisms of the TNF-α gene and susceptibility to cervical cancer. The relationship between a single nucleotide polymorphism (SNP) in the TNF-α gene (rs1800629) and the risk of cervical cancer was evaluated in a total of 445 subjects with (n = 153), or without (n = 292) cancer. Genotyping was performed using a Taq-Man based real time PCR method. Logistic regression analysis showed that individuals with AG/AA genotypes had an increased risk of cervical cancer compared to those with a GG genotype (OR 3.79, 95% CI 2.4–5.7, < 0.001). Our findings demonstrated that a genetic variant in the TNF-α gene (rs1800629) was associated with increased level and risk of developing cervical cancer, suggesting its potential use as a genetic risk factor for cervical neoplasia.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-021-06185-4</identifier><identifier>PMID: 33555528</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Cervical cancer ; Cervix ; Circumcision ; Female ; Gene polymorphism ; Genetic Association Studies ; Genetic diversity ; Genetic Predisposition to Disease ; Genotype ; Genotyping ; Histology ; Humans ; Immune system ; Inflammation ; Life Sciences ; Middle Aged ; Morphology ; Necrosis ; Original Article ; Polymorphism, Single Nucleotide - genetics ; Risk Factors ; Single-nucleotide polymorphism ; Tumor Necrosis Factor-alpha - genetics ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Molecular biology reports, 2021-02, Vol.48 (2), p.1433-1437</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b1c133c39e55fd31164967ad7c68cc39c45b8366e58e897aab206d62fceb0ab63</citedby><cites>FETCH-LOGICAL-c375t-b1c133c39e55fd31164967ad7c68cc39c45b8366e58e897aab206d62fceb0ab63</cites><orcidid>0000-0002-8263-0828</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-021-06185-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-021-06185-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33555528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behboodi, Negin</creatorcontrib><creatorcontrib>Farazestanian, Marjaneh</creatorcontrib><creatorcontrib>Rastgar-Moghadam, Azam</creatorcontrib><creatorcontrib>Mehramiz, Mehrane</creatorcontrib><creatorcontrib>Karimi, Ehsan</creatorcontrib><creatorcontrib>Rajabian, Majid</creatorcontrib><creatorcontrib>Rahmani, Farzad</creatorcontrib><creatorcontrib>Khorrami, Shadi</creatorcontrib><creatorcontrib>Jafarian, Amirhosein</creatorcontrib><creatorcontrib>Sharifi-Sistani, Noorieh</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><creatorcontrib>Hasanzadeh, Malihe</creatorcontrib><title>Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the regulation of the immune system and potentially the progression of cervical neoplastic lesions. In this study, we aimed to explore the possible relationship between polymorphisms of the TNF-α gene and susceptibility to cervical cancer. The relationship between a single nucleotide polymorphism (SNP) in the TNF-α gene (rs1800629) and the risk of cervical cancer was evaluated in a total of 445 subjects with (n = 153), or without (n = 292) cancer. Genotyping was performed using a Taq-Man based real time PCR method. Logistic regression analysis showed that individuals with AG/AA genotypes had an increased risk of cervical cancer compared to those with a GG genotype (OR 3.79, 95% CI 2.4–5.7, < 0.001). Our findings demonstrated that a genetic variant in the TNF-α gene (rs1800629) was associated with increased level and risk of developing cervical cancer, suggesting its potential use as a genetic risk factor for cervical neoplasia.</description><subject>Adult</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Circumcision</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Histology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Necrosis</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide - 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In this study, we aimed to explore the possible relationship between polymorphisms of the TNF-α gene and susceptibility to cervical cancer. The relationship between a single nucleotide polymorphism (SNP) in the TNF-α gene (rs1800629) and the risk of cervical cancer was evaluated in a total of 445 subjects with (n = 153), or without (n = 292) cancer. Genotyping was performed using a Taq-Man based real time PCR method. Logistic regression analysis showed that individuals with AG/AA genotypes had an increased risk of cervical cancer compared to those with a GG genotype (OR 3.79, 95% CI 2.4–5.7, < 0.001). 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| subjects | Adult Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cervical cancer Cervix Circumcision Female Gene polymorphism Genetic Association Studies Genetic diversity Genetic Predisposition to Disease Genotype Genotyping Histology Humans Immune system Inflammation Life Sciences Middle Aged Morphology Necrosis Original Article Polymorphism, Single Nucleotide - genetics Risk Factors Single-nucleotide polymorphism Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Tumor necrosis factor-α Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology |
| title | Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer |
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