From diabetes to renal aging: the therapeutic potential of adiponectin
Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunc...
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Veröffentlicht in: | Journal of physiology and biochemistry 2021-05, Vol.77 (2), p.205-214 |
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creator | Karamian, Mehdi Moossavi, Maryam Hemmati, Mina |
description | Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunction in diabetes. Due to recent studies, adiponectin plays a key role in diabetes-related kidney diseases as a fat-derived hormone. In diabetes, reduced adiponectin levels are associated to renal cell aging. Oxidative stress and related signaling pathways are the main routes in which adiponectin may be effective to decline diabetes-associated aging. Therefore, adiponectin signaling in target tissues becomes one of the research areas of interest in metabolism and clinical medicine. Studies on adiponectin signaling will increase our understanding of adiponectin role in diabetes-linked diseases as well as shortening life span conditions which may guide the design of antidiabetic and anti-aging drugs. |
doi_str_mv | 10.1007/s13105-021-00790-4 |
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Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunction in diabetes. Due to recent studies, adiponectin plays a key role in diabetes-related kidney diseases as a fat-derived hormone. In diabetes, reduced adiponectin levels are associated to renal cell aging. Oxidative stress and related signaling pathways are the main routes in which adiponectin may be effective to decline diabetes-associated aging. Therefore, adiponectin signaling in target tissues becomes one of the research areas of interest in metabolism and clinical medicine. 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Studies on adiponectin signaling will increase our understanding of adiponectin role in diabetes-linked diseases as well as shortening life span conditions which may guide the design of antidiabetic and anti-aging drugs.</description><subject>Adiponectin</subject><subject>Aging</subject><subject>Animal Physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Clinical medicine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Drug development</subject><subject>Human Physiology</subject><subject>Kidney diseases</subject><subject>Life span</subject><subject>Nephropathy</subject><subject>Oxidative stress</subject><subject>Renal function</subject><subject>Review</subject><subject>Signaling</subject><subject>Thickening</subject><issn>1138-7548</issn><issn>1877-8755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQQC0EoqXwBxhQJBaWgD_i2mFDFQWkSiwwW0l8KanSONjOwL_nSgpIDFiy7NO9O58fIeeMXjNK1U1gglGZUs5SDHOaZgdkyrRSqVZSHuKdCZ0qmekJOQlhQ2nGGafHZCKExCX4lCyX3m0T2xQlRAhJdImHrmiTYt1069skvsFu-6KHITZV0rsIXWwQcHVS2KZ3HVSx6U7JUV20Ac7254y8Lu9fFo_p6vnhaXG3SiuhZEythbJUONVc5hmtdC3nKs_qHErQ3NaVtgIzVHArMdQUJ7Y255TWkitpmZiRq7Fv7937ACGabRMqaNuiAzcEwzOtMq5RBqKXf9CNGzz-DaldN1TE50jxkaq8C8FDbXrfbAv_YRg1O8tmtGzQsvmybDIsuti3Hsot2J-Sb60IiBEImOrW4H_f_qftJ0C-hgY</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Karamian, Mehdi</creator><creator>Moossavi, Maryam</creator><creator>Hemmati, Mina</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9401-5067</orcidid></search><sort><creationdate>20210501</creationdate><title>From diabetes to renal aging: the therapeutic potential of adiponectin</title><author>Karamian, Mehdi ; Moossavi, Maryam ; Hemmati, Mina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ddebb713865940c8f56794f9ebe82dfc8d3659032d52df80004dd9200f5275d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adiponectin</topic><topic>Aging</topic><topic>Animal Physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Clinical medicine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Drug development</topic><topic>Human Physiology</topic><topic>Kidney diseases</topic><topic>Life span</topic><topic>Nephropathy</topic><topic>Oxidative stress</topic><topic>Renal function</topic><topic>Review</topic><topic>Signaling</topic><topic>Thickening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karamian, Mehdi</creatorcontrib><creatorcontrib>Moossavi, Maryam</creatorcontrib><creatorcontrib>Hemmati, Mina</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karamian, Mehdi</au><au>Moossavi, Maryam</au><au>Hemmati, Mina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From diabetes to renal aging: the therapeutic potential of adiponectin</atitle><jtitle>Journal of physiology and biochemistry</jtitle><stitle>J Physiol Biochem</stitle><addtitle>J Physiol Biochem</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>77</volume><issue>2</issue><spage>205</spage><epage>214</epage><pages>205-214</pages><issn>1138-7548</issn><eissn>1877-8755</eissn><abstract>Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. 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subjects | Adiponectin Aging Animal Physiology Biomedical and Life Sciences Biomedicine Clinical medicine Diabetes Diabetes mellitus Drug development Human Physiology Kidney diseases Life span Nephropathy Oxidative stress Renal function Review Signaling Thickening |
title | From diabetes to renal aging: the therapeutic potential of adiponectin |
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