From diabetes to renal aging: the therapeutic potential of adiponectin

Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunc...

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Veröffentlicht in:Journal of physiology and biochemistry 2021-05, Vol.77 (2), p.205-214
Hauptverfasser: Karamian, Mehdi, Moossavi, Maryam, Hemmati, Mina
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creator Karamian, Mehdi
Moossavi, Maryam
Hemmati, Mina
description Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunction in diabetes. Due to recent studies, adiponectin plays a key role in diabetes-related kidney diseases as a fat-derived hormone. In diabetes, reduced adiponectin levels are associated to renal cell aging. Oxidative stress and related signaling pathways are the main routes in which adiponectin may be effective to decline diabetes-associated aging. Therefore, adiponectin signaling in target tissues becomes one of the research areas of interest in metabolism and clinical medicine. Studies on adiponectin signaling will increase our understanding of adiponectin role in diabetes-linked diseases as well as shortening life span conditions which may guide the design of antidiabetic and anti-aging drugs.
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subjects Adiponectin
Aging
Animal Physiology
Biomedical and Life Sciences
Biomedicine
Clinical medicine
Diabetes
Diabetes mellitus
Drug development
Human Physiology
Kidney diseases
Life span
Nephropathy
Oxidative stress
Renal function
Review
Signaling
Thickening
title From diabetes to renal aging: the therapeutic potential of adiponectin
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