Enzyme engineering and its industrial applications
Recently, there has been an increase in the demand for enzymes with modified activity, specificity, and stability. Enzyme engineering is an important tool to meet the demand for enzymes adjusted to different industrial processes. Knowledge of the structure and function of enzymes guides the choice o...
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Veröffentlicht in: | Biotechnology and applied biochemistry 2022-04, Vol.69 (2), p.389-409 |
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creator | Victorino da Silva Amatto, Isabela Gonsales da Rosa‐Garzon, Nathalia Antônio de Oliveira Simões, Flávio Santiago, Fernanda Pereira da Silva Leite, Nathália Raspante Martins, Júlia Cabral, Hamilton |
description | Recently, there has been an increase in the demand for enzymes with modified activity, specificity, and stability. Enzyme engineering is an important tool to meet the demand for enzymes adjusted to different industrial processes. Knowledge of the structure and function of enzymes guides the choice of the best strategy for engineering enzymes. Each enzyme engineering strategy, such as rational design, directed evolution, and semi‐rational design, has specific applications, as well as limitations, which must be considered when choosing a suitable strategy. Engineered enzymes can be optimized for different industrial applications by choosing the appropriate strategy. This review features engineered enzymes that have been applied in food, animal feed, pharmaceuticals, medical applications, bioremediation, biofuels, and detergents.
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Integration of various techniques for obtaining modified enzymes. |
doi_str_mv | 10.1002/bab.2117 |
format | Article |
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Integration of various techniques for obtaining modified enzymes.</description><identifier>ISSN: 0885-4513</identifier><identifier>EISSN: 1470-8744</identifier><identifier>DOI: 10.1002/bab.2117</identifier><identifier>PMID: 33555054</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animal feed ; Animals ; Biocatalysis ; Biodegradation, Environmental ; Biofuels ; Bioremediation ; Biotechnology ; Detergents ; Directed evolution ; Engineering ; Enzymes ; Enzymes - chemistry ; Feeds ; Industrial applications ; Industry ; Protein Engineering ; rational design ; semi‐rational design ; Structure-function relationships</subject><ispartof>Biotechnology and applied biochemistry, 2022-04, Vol.69 (2), p.389-409</ispartof><rights>2021 International Union of Biochemistry and Molecular Biology, Inc.</rights><rights>2022 International Union of Biochemistry and Molecular Biology, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3497-269d1dbe2b2e3808bb1549c96773e6f3cb6523180e67d4484b95efac67135693</citedby><cites>FETCH-LOGICAL-c3497-269d1dbe2b2e3808bb1549c96773e6f3cb6523180e67d4484b95efac67135693</cites><orcidid>0000-0002-7365-1694</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbab.2117$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbab.2117$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33555054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Victorino da Silva Amatto, Isabela</creatorcontrib><creatorcontrib>Gonsales da Rosa‐Garzon, Nathalia</creatorcontrib><creatorcontrib>Antônio de Oliveira Simões, Flávio</creatorcontrib><creatorcontrib>Santiago, Fernanda</creatorcontrib><creatorcontrib>Pereira da Silva Leite, Nathália</creatorcontrib><creatorcontrib>Raspante Martins, Júlia</creatorcontrib><creatorcontrib>Cabral, Hamilton</creatorcontrib><title>Enzyme engineering and its industrial applications</title><title>Biotechnology and applied biochemistry</title><addtitle>Biotechnol Appl Biochem</addtitle><description>Recently, there has been an increase in the demand for enzymes with modified activity, specificity, and stability. Enzyme engineering is an important tool to meet the demand for enzymes adjusted to different industrial processes. Knowledge of the structure and function of enzymes guides the choice of the best strategy for engineering enzymes. Each enzyme engineering strategy, such as rational design, directed evolution, and semi‐rational design, has specific applications, as well as limitations, which must be considered when choosing a suitable strategy. Engineered enzymes can be optimized for different industrial applications by choosing the appropriate strategy. This review features engineered enzymes that have been applied in food, animal feed, pharmaceuticals, medical applications, bioremediation, biofuels, and detergents.
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Integration of various techniques for obtaining modified enzymes.</description><subject>Animal feed</subject><subject>Animals</subject><subject>Biocatalysis</subject><subject>Biodegradation, Environmental</subject><subject>Biofuels</subject><subject>Bioremediation</subject><subject>Biotechnology</subject><subject>Detergents</subject><subject>Directed evolution</subject><subject>Engineering</subject><subject>Enzymes</subject><subject>Enzymes - chemistry</subject><subject>Feeds</subject><subject>Industrial applications</subject><subject>Industry</subject><subject>Protein Engineering</subject><subject>rational design</subject><subject>semi‐rational design</subject><subject>Structure-function relationships</subject><issn>0885-4513</issn><issn>1470-8744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQQBdRbK2Cv0ACXrxE93s3x7bUDyh46X3ZTSZlS7KJ2Qapv97UVgXB01web2YeQtcE3xOM6YOz7p4Sok7QmHCFU604P0VjrLVIuSBshC5i3GCMtdL0HI0YE0JgwceILsLHroYEwtoHgM6HdWJDkfhtTHwo-rjtvK0S27aVz-3WNyFeorPSVhGujnOCVo-L1fw5Xb4-vcynyzRnPFMplVlBCgfUUWAaa-eI4FmeSaUYyJLlTgrKiMYgVcG55i4TUNpcKsKEzNgE3R20bde89RC3pvYxh6qyAZo-GsqHL6mWkg_o7R900_RdGI4zdFiCCadE_Qrzromxg9K0na9ttzMEm31GM2Q0-4wDenMU9q6G4gf87jYA6QF49xXs_hWZ2XT2JfwEQaV4vw</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Victorino da Silva Amatto, Isabela</creator><creator>Gonsales da Rosa‐Garzon, Nathalia</creator><creator>Antônio de Oliveira Simões, Flávio</creator><creator>Santiago, Fernanda</creator><creator>Pereira da Silva Leite, Nathália</creator><creator>Raspante Martins, Júlia</creator><creator>Cabral, Hamilton</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TB</scope><scope>7TK</scope><scope>7U5</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>L7M</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7365-1694</orcidid></search><sort><creationdate>202204</creationdate><title>Enzyme engineering and its industrial applications</title><author>Victorino da Silva Amatto, Isabela ; 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Enzyme engineering is an important tool to meet the demand for enzymes adjusted to different industrial processes. Knowledge of the structure and function of enzymes guides the choice of the best strategy for engineering enzymes. Each enzyme engineering strategy, such as rational design, directed evolution, and semi‐rational design, has specific applications, as well as limitations, which must be considered when choosing a suitable strategy. Engineered enzymes can be optimized for different industrial applications by choosing the appropriate strategy. This review features engineered enzymes that have been applied in food, animal feed, pharmaceuticals, medical applications, bioremediation, biofuels, and detergents.
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Integration of various techniques for obtaining modified enzymes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33555054</pmid><doi>10.1002/bab.2117</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-7365-1694</orcidid></addata></record> |
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source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Animal feed Animals Biocatalysis Biodegradation, Environmental Biofuels Bioremediation Biotechnology Detergents Directed evolution Engineering Enzymes Enzymes - chemistry Feeds Industrial applications Industry Protein Engineering rational design semi‐rational design Structure-function relationships |
title | Enzyme engineering and its industrial applications |
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